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Deep learning-based AI models have been extensively applied in genomics, achieving remarkable success across diverse applications. As these models gain prominence, there exists an urgent need for interpretability methods to establish…

Genomics · Quantitative Biology 2025-05-16 Chenyu Wang , Chaoying Zuo , Zihan Su , Yuhang Xing , Lu Li , Maojun Wang , Zeyu Zhang

Along with the great success of deep neural networks, there is also growing concern about their black-box nature. The interpretability issue affects people's trust on deep learning systems. It is also related to many ethical problems, e.g.,…

Machine Learning · Computer Science 2022-02-01 Yu Zhang , Peter Tiňo , Aleš Leonardis , Ke Tang

Interpretable machine learning has become a strong competitor for traditional black-box models. However, the possible loss of the predictive performance for gaining interpretability is often inevitable, putting practitioners in a dilemma of…

Machine Learning · Computer Science 2019-05-13 Tong Wang , Qihang Lin

Despite the high performance of neural network-based time series forecasting methods, the inherent challenge in explaining their predictions has limited their applicability in certain application areas. Due to the difficulty in identifying…

Machine Learning · Computer Science 2023-01-09 Ozan Ozyegen , Juyoung Wang , Mucahit Cevik

We review the main applications of machine learning models that are not fully supervised in particle physics, i.e., clustering, anomaly detection, detector simulation, and unfolding. Unsupervised methods are ideal for anomaly detection…

High Energy Physics - Phenomenology · Physics 2024-10-24 Jai Bardhan , Tanumoy Mandal , Subhadip Mitra , Cyrin Neeraj , Monalisa Patra

Artificial neural networks have long been understood as "black boxes": though we know their computation graphs and learned parameters, the knowledge encoded by these weights and functions they perform are not inherently interpretable. As…

Artificial Intelligence · Computer Science 2024-08-13 Adam Davies , Ashkan Khakzar

The ability to interpret machine learning models has become increasingly important now that machine learning is used to inform consequential decisions. We propose an approach called model extraction for interpreting complex, blackbox…

Machine Learning · Computer Science 2018-03-14 Osbert Bastani , Carolyn Kim , Hamsa Bastani

Image decomposition aims to analyze an image into elementary components, which is essential for numerous downstream tasks and also by nature provides certain interpretability to the analysis. Deep learning can be powerful for such tasks,…

Computer Vision and Pattern Recognition · Computer Science 2025-01-03 Sihan Wang , Shangqi Gao , Fuping Wu , Xiahai Zhuang

The increasing use of complex machine learning models in education has led to concerns about their interpretability, which in turn has spurred interest in developing explainability techniques that are both faithful to the model's inner…

Machine Learning · Computer Science 2025-05-13 Juan D. Pinto , Luc Paquette

As the discipline has evolved, research in machine learning has been focused more and more on creating more powerful neural networks, without regard for the interpretability of these networks. Such "black-box models" yield state-of-the-art…

Machine Learning · Computer Science 2021-09-02 Lachlan O'Neill , Simon Angus , Satya Borgohain , Nader Chmait , David L. Dowe

In recent years, machine learning (ML) has become a key enabling technology for the sciences and industry. Especially through improvements in methodology, the availability of large databases and increased computational power, today's ML…

Artificial Intelligence · Computer Science 2019-09-27 Wojciech Samek , Klaus-Robert Müller

Mechanistic interpretability (MI) is an emerging framework for interpreting neural networks. Given a task and model, MI aims to discover a succinct algorithmic process, an interpretation, that explains the model's decision process on that…

Machine Learning · Computer Science 2026-04-01 Alan Sun , Mariya Toneva

Classification of quantum phases is one of the most important areas of research in condensed matter physics. In this work, we obtain the phase diagram of one-dimensional quasiperiodic models via unsupervised learning. Firstly, we choose two…

Disordered Systems and Neural Networks · Physics 2024-10-22 Bohan Zheng , Siyu Zhu , Xingping Zhou , Tong Liu

Interpretation of medical images for diagnosis and treatment of complex disease from high-dimensional and heterogeneous data remains a key challenge in transforming healthcare. In the last few years, both supervised and unsupervised deep…

Image and Video Processing · Electrical Eng. & Systems 2018-12-20 Khalid Raza , Nripendra Kumar Singh

Supervised machine learning often operates on the data-driven paradigm, wherein internal model parameters are autonomously optimized to converge predicted outputs with the ground truth, devoid of explicitly programming rules or a priori…

Machine Learning · Computer Science 2024-12-12 Daniel Geissler , Bo Zhou , Mengxi Liu , Paul Lukowicz

For performing regression tasks involved in various physics problems, enhancing the precision or equivalently reducing the uncertainty of regression results is undoubtedly one of the central goals. Here, somewhat surprisingly, we find that…

Statistical Mechanics · Physics 2023-11-09 Wei-Chen Guo , Liang He

As machine learning systems become ubiquitous, there has been a surge of interest in interpretable machine learning: systems that provide explanation for their outputs. These explanations are often used to qualitatively assess other…

Machine Learning · Statistics 2017-03-06 Finale Doshi-Velez , Been Kim

In this review, we examine the problem of designing interpretable and explainable machine learning models. Interpretability and explainability lie at the core of many machine learning and statistical applications in medicine, economics,…

Machine Learning · Computer Science 2023-03-02 Ričards Marcinkevičs , Julia E. Vogt

This paper explores the mechanistic interpretability of reinforcement learning (RL) agents through an analysis of a neural network trained on procedural maze environments. By dissecting the network's inner workings, we identified…

Machine Learning · Computer Science 2024-11-05 Tristan Trim , Triston Grayston

The impressive capabilities of deep learning models are often counterbalanced by their inherent opacity, commonly termed the "black box" problem, which impedes their widespread acceptance in high-trust domains. In response, the intersecting…

Machine Learning · Computer Science 2025-09-16 Mitali Raj