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When modeling complex, hierarchical, and time-dynamic systems, such as biological systems, good computational tools are essential. Current tools, while powerful, often lack comprehensive frameworks for modular model composition,…

Quantitative Methods · Quantitative Biology 2025-10-17 Henrik Podéus , Gustav Magnusson , Sasan Keshmiri , Kajsa Tunedal , Nicolas Sundqvist , William Lövfors , Gunnar Cedersund

This article presents the development and validation of a hybrid multi-sphere discrete element framework - Rigid3D, for the simulation of granular systems with arbitrarily shaped particles in 3D space. In this DEM framework, a non-spherical…

Computational Engineering, Finance, and Science · Computer Science 2023-06-27 Fei-Liang Yuan , Martin Sommerfeld , Pradeep Muramulla , Srikanth Gopireddy , Lars Pasternak , Nora Urbanetz , Thomas Profitlich

We present a model for cell growth, division and packing under soft constraints that arise from the deformability of the cells as well as of a membrane that encloses them. Our treatment falls within the framework of diffuse interface…

Cell Behavior · Quantitative Biology 2019-01-09 J. Jiang , K. Garikipati , S. Rudraraju

Simulation code for conventional supercomputers serves as a reference for neuromorphic computing systems. The present bottleneck of distributed large-scale spiking neuronal network simulations is the communication between compute nodes.…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-27 Melissa Lober , Markus Diesmann , Susanne Kunkel

Multi-cell cooperative processing with limited backhaul traffic is studied for cellular uplinks. Aiming at reduced backhaul overhead, a sparsity-regularized multi-cell receive-filter design problem is formulated. Both unstructured…

Information Theory · Computer Science 2015-10-16 Swayambhoo Jain , Seung-Jun Kim , Georgios B. Giannakis

We propose a probabilistic framework for developing computational models of biological neural systems. In this framework, physiological recordings are viewed as discrete-time partial observations of an underlying continuous-time stochastic…

Neurons and Cognition · Quantitative Biology 2026-02-10 Ahmed ElGazzar , Marcel van Gerven

Large-scale distributed computing infrastructures such as the Worldwide LHC Computing Grid (WLCG) require comprehensive simulation tools for evaluating performance, testing new algorithms, and optimizing resource allocation strategies.…

This chapter provides a brief introduction to the theory and practice of spatial stochastic simulations. It begins with an overview of different methods available for biochemical simulations highlighting their strengths and limitations.…

Quantitative Methods · Quantitative Biology 2018-10-02 Sanjana Gupta , Jacob Czech , Robert Kuczewski , Thomas M. Bartol , Terrence J. Sejnowski , Robin E. C. Lee , James R. Faeder

Through massive deployment of additional small cell infrastructure, Dense Small cell Networks (DSNs) are expected to help meet the foreseen increase in traffic demand on cellular networks. Performance assessment of architectural and…

Networking and Internet Architecture · Computer Science 2015-10-12 Pedro Alvarez , Carlo Galiotto , Jonathan van de Belt , Danny Finn , Hamed Ahmadi , Luiz DaSilva

A high activity of reactions can be confined in a model cell with a semipermeable membrane in the Schl\"ogl model. It is interpreted as a model of primitive metabolism in a cell. We study two generalized models to understand the creation of…

Adaptation and Self-Organizing Systems · Physics 2009-11-13 Hidetsugu Sakaguchi

Complex network dynamics have been analyzed with models of systems of coupled switches or systems of coupled oscillators. However, many complex systems are composed of components with diverse dynamics whose interactions drive the system's…

Quantitative Methods · Quantitative Biology 2012-01-09 Matthew R. Francis , Elana J. Fertig

We present a new design pattern for high-performance parallel scientific software, named coalesced communication. This pattern allows for a structured way to improve the communication performance through coalescence of multiple…

Distributed, Parallel, and Cluster Computing · Computer Science 2012-10-17 Hywel B. Carver , Derek Groen , James Hetherington , Rupert W. Nash , Miguel O. Bernabeu , Peter V. Coveney

Non-orthogonal multiple access (NOMA) allows multiple users to simultaneously access the same time-frequency resource by using superposition coding and successive interference cancellation (SIC). Thus far, most papers on NOMA have focused…

Information Theory · Computer Science 2017-12-12 Lei You , Lei Lei , Di Yuan , Sumei Sun , Symeon Chatzinotas , Björn Ottersten

In this work, we make use of the OpenCL framework to accelerate an EMRI modeling application using the hardware accelerators -- Cell BE and Tesla CUDA GPU. We describe these compute technologies and our parallelization approach in detail,…

General Relativity and Quantum Cosmology · Physics 2011-10-05 Gaurav Khanna , Justin McKennon

The numerical simulation of multiphase flows involving dispersed components with large scale disparities, such as the collisions between millimeter-sized bubbles and micron-sized mineral particles in flotation, poses a significant…

Fluid Dynamics · Physics 2026-05-21 Linfeng Jiang , Enrico Calzavarini , Dominik Krug

Developing dedicated mixed-signal neuromorphic computing systems optimized for real-time sensory-processing in extreme edge-computing applications requires time-consuming design, fabrication, and deployment of full-custom neuromorphic…

Neural and Evolutionary Computing · Computer Science 2025-08-18 Fernando M. Quintana , Maryada , Pedro L. Galindo , Elisa Donati , Giacomo Indiveri , Fernando Perez-Peña

Multi-agent systems (MAS) demonstrate clear advantages in tackling complex problems by coordinating diverse agents and external tools. However, most existing orchestration methods rely on static workflows or serial agent scheduling, and are…

Artificial Intelligence · Computer Science 2026-04-21 Wenzhen Yuan , Wutao Xiong , Fanchen Yu , Shengji Tang , Ting Liu , Tao Chen , Peng Ye , Yuzhuo Fu , Wanli Ouyang , Lei Bai

Biological cells rely on precise spatiotemporal coordination of biochemical reactions to control their many functions. Such cell signaling networks have been a common focus for mathematical models, but they remain challenging to simulate,…

This paper contributes the Aerial Gym Simulator, a highly parallelized, modular framework for simulation and rendering of arbitrary multirotor platforms based on NVIDIA Isaac Gym. Aerial Gym supports the simulation of under-, fully- and…

Robotics · Computer Science 2025-03-04 Mihir Kulkarni , Welf Rehberg , Kostas Alexis

Tingkat kompleksitas dari program simulasi dinamika molekular membutuhkan mesin pemroses dengan kemampuan yang sangat besar. Mesin-mesin paralel terbukti memiliki potensi untuk menjawab tantangan komputasi ini. Untuk memanfaatkan potensi…

Distributed, Parallel, and Cluster Computing · Computer Science 2008-07-30 A. B. Mutiara
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