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There has recently been growing evidence that atrial fibrillation (AF), the most common cardiac arrhythmia, is independently associated with the risk of dementia. This represents a very recent frontier with high social impact for the number…

Atrial fibrillation (AF) is the most common arrhythmia affecting millions of people in the Western countries and, due to the widespread impact on the population and its medical relevance, is largely investigated in both clinical and…

Medical Physics · Physics 2014-09-12 Stefania Scarsoglio , Andrea Guala , Carlo Camporeale , Luca Ridolfi

Background. Different mechanisms have been proposed to relate atrial fibrillation (AF) and coronary flow impairment, even in absence of relevant coronary artery disease (CAD). However, the underlying hemodynamics remains unclear. Aim of the…

Medical Physics · Physics 2019-04-17 Stefania Scarsoglio , Caterina Gallo , Andrea Saglietto , Luca Ridolfi , Matteo Anselmino

Atrial fibrillation (AF) is the most common cardiac arrhythmia in human beings, and is associated with significant morbidity and mortality. The current standard of care includes interventional catheter ablation in selected patients, but the…

A network-based approach is presented to investigate the cerebrovascular flow patterns during atrial fibrillation (AF) with respect to normal sinus rhythm (NSR). AF, the most common cardiac arrhythmia with faster and irregular beating, has…

Data Analysis, Statistics and Probability · Physics 2017-09-27 Stefania Scarsoglio , Fabio Cazzato , Luca Ridolfi

Atrial Fibrillation (AF) is the most common type of arrhythmia (Greek a-, loss + rhythmos, rhythm = loss of rhythm) leading to hospitalization in the United States. Though sometimes AF is asymptomatic, it increases the risk of stroke and…

Machine Learning · Computer Science 2021-09-22 Samayan Bhattacharya , Sk Shahnawaz

Atrial fibrillation (AF) is the most common abnormal heart rhythm and the single biggest cause of stroke. Ablation, destroying regions of the atria, is applied largely empirically and can be curative but with a disappointing clinical…

Medical Physics · Physics 2015-06-19 Kim Christensen , Kishan A. Manani , Nicholas S. Peters

Atrial fibrillation (AF) is associated with cognitive impairment/dementia, independently of clinical cerebrovascular events (stroke/TIA). One of the plausible mechanisms is the occurrence of AF-induced transient critical hemodynamic events;…

Medical Physics · Physics 2019-03-11 Andrea Saglietto , Stefania Scarsoglio , Luca Ridolfi , Fiorenzo Gaita , Matteo Anselmino

Atrial fibrillation (AF) consequences on the heart valve dynamics are usually studied along with a valvular disfunction or disease, since in medical monitoring the two pathologies are often concomitant. Aim of the present work is to study,…

Fluid Dynamics · Physics 2015-10-27 Stefania Scarsoglio , Carlo Camporeale , Andrea Guala , Luca Ridolfi

Atrial fibrillation (AF) increases the risk of stroke by a factor of four to five and is the most common abnormal heart rhythm. The progression of AF with age, from short self-terminating episodes to persistence, varies between individuals…

Tissues and Organs · Quantitative Biology 2016-10-12 Kishan A. Manani , Kim Christensen , Nicholas S. Peters

Although atrial fibrillation (AF), a common arrhythmia, frequently presents in patients with underlying valvular disease, its hemodynamic contributions are not fully understood. The present work aimed to computationally study how physical…

Atrial fibrillation (AF) is associated with an increased risk of dementia and cognitive decline, independent of strokes. Several mechanisms have been proposed to explain this association, but altered cerebral blood flow dynamics during AF…

Medical Physics · Physics 2016-06-24 Matteo Anselmino , Stefania Scarsoglio , Andrea Saglietto , Fiorenzo Gaita , Luca Ridolfi

Atrial fibrillation (AF) is a leading cause of morbidity and mortality. AF prevalence increases with age, which is attributed to pathophysiological changes that aid AF initiation and perpetuation. Current state-of-the-art models are only…

Tissues and Organs · Quantitative Biology 2015-10-05 Julie Eatock , Yen Ting Lin , Eugene T. Y. Chang , Tobias Galla , Richard H. Clayton

Heart rate variability (HRV) indices describe properties of interbeat intervals in electrocardiogram (ECG). Usually HRV is measured exclusively in normal sinus rhythm (NSR) excluding any form of paroxysmal rhythm. Atrial fibrillation (AF)…

Applications · Statistics 2023-08-28 Nikita Markov , Ilya Kotov , Konstantin Ushenin , Yakov Bozhko

Aims. Clinical data indicating a heart rate (HR) target during rate control therapy for permanent atrial fibrillation (AF) and assessing its eventual relationship with reduced exercise tolerance are lacking. The present study aims at…

Medical Physics · Physics 2017-01-17 Matteo Anselmino , Stefania Scarsoglio , Andrea Saglietto , Fiorenzo Gaita , Luca Ridolfi

We propose a stochastic individual-based model of the progression of atrial fibrillation (AF). The model operates at patient level over a lifetime and is based on elements of the physiology and biophysics of AF, making contact with existing…

Populations and Evolution · Quantitative Biology 2015-07-29 Eugene TY Chang , Yen Ting Lin , Tobias Galla , Richard H Clayton , Julie Eatock

Atrial fibrillation (AF) is one of the most prevalent cardiac arrhythmias that affects the lives of more than 3 million people in the U.S. and over 33 million people around the world and is associated with a five-fold increased risk of…

Quantitative Methods · Quantitative Biology 2020-02-14 Sajad Mousavi , Fatemeh Afghah , U. Rajendra Acharya

Atrial fibrillation (AF) is the most prevalent cardiac arrhythmia worldwide, with 2% of the population affected. It is associated with an increased risk of strokes, heart failure and other heart-related complications. Monitoring at-risk…

Machine Learning · Computer Science 2021-11-24 Sideshwar J B , Sachin Krishan T , Vishal Nagarajan , Shanthakumar S , Vineeth Vijayaraghavan

Background. Despite the routine prescription of rate control therapy for atrial fibrillation (AF), clinical evidence demonstrating a heart rate target is lacking. Aim of the present study was to run a mathematical model simulating AF…

The mechanism of atrial fibrillation (AF) is poorly understood, resulting in disappointing success rates of ablative treatment. Different mechanisms defined largely by different atrial activation patterns have been proposed and, arguably,…

Tissues and Organs · Quantitative Biology 2020-01-27 Max Falkenberg , Andrew J. Ford , Anthony C. Li , Alberto Ciacci , Nicholas S. Peters , Kim Christensen
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