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A molecule's geometry, also known as conformation, is one of a molecule's most important properties, determining the reactions it participates in, the bonds it forms, and the interactions it has with other molecules. Conventional…

Machine Learning · Computer Science 2020-01-01 Elman Mansimov , Omar Mahmood , Seokho Kang , Kyunghyun Cho

Mapping complex input data into suitable lower dimensional manifolds is a common procedure in machine learning. This step is beneficial mainly for two reasons: (1) it reduces the data dimensionality and (2) it provides a new data…

Machine Learning · Computer Science 2018-11-28 Daniele Zambon , Lorenzo Livi , Cesare Alippi

Graph, as an important data representation, is ubiquitous in many real world applications ranging from social network analysis to biology. How to correctly and effectively learn and extract information from graph is essential for a large…

Machine Learning · Computer Science 2020-10-27 Xiaodong Jiang , Ronghang Zhu , Pengsheng Ji , Sheng Li

In this study, we intend to solve a mutual information problem in interacting molecules of any type, such as proteins, nucleic acids, and small molecules. Using machine learning techniques, we accurately predict pairwise interactions, which…

Machine Learning · Statistics 2016-01-28 Andrew Schaumberg , Angela Yu , Tatsuhiro Koshi , Xiaochan Zong , Santoshkalyan Rayadhurgam

Despite quick progress in the last few years, recent studies have shown that modern graph neural networks can still fail at very simple tasks, like detecting small cycles. This hints at the fact that current networks fail to catch…

Machine Learning · Computer Science 2021-06-04 Rémy Brossard , Oriel Frigo , David Dehaene

In graph learning, maps between graphs and their subgraphs frequently arise. For instance, when coarsening or rewiring operations are present along the pipeline, one needs to keep track of the corresponding nodes between the original and…

Machine Learning · Computer Science 2023-02-01 Marco Pegoraro , Riccardo Marin , Arianna Rampini , Simone Melzi , Luca Cosmo , Emanuele Rodolà

We challenge black-box purely deep neural approaches for molecules and graph generation, which are limited in controllability and lack formal guarantees. We introduce Neuro-Symbolic Graph Generative Modeling (NSGGM), a neurosymbolic…

Machine Learning · Computer Science 2026-02-25 Chuqin Geng , Li Zhang , Mark Zhang , Haolin Ye , Ziyu Zhao , Xujie Si

Malware detection has become a major concern due to the increasing number and complexity of malware. Traditional detection methods based on signatures and heuristics are used for malware detection, but unfortunately, they suffer from poor…

Cryptography and Security · Computer Science 2023-08-21 Tristan Bilot , Nour El Madhoun , Khaldoun Al Agha , Anis Zouaoui

Graph Neural Networks (GNNs) offer a compact and computationally efficient way to learn embeddings and classifications on graph data. GNN models are frequently large, making distributed minibatch training necessary. The primary contribution…

Machine Learning · Computer Science 2024-04-22 Alok Tripathy , Katherine Yelick , Aydin Buluc

In this paper, we review recent developments and the role of Graph Neural Networks (GNNs) in computational drug discovery, including molecule generation, molecular property prediction, and drug-drug interaction prediction. By summarizing…

Machine Learning · Computer Science 2025-06-03 Zhengyu Fang , Xiaoge Zhang , Anyin Zhao , Xiao Li , Huiyuan Chen , Jing Li

This paper presents primarily two Euclidean embeddings of the quotient space generated by matrices that are identified modulo arbitrary row permutations. The original application is in deep learning on graphs where the learning task is…

Functional Analysis · Mathematics 2022-03-16 Radu Balan , Naveed Haghani , Maneesh Singh

Graph generation techniques are increasingly being adopted for drug discovery. Previous graph generation approaches have utilized relatively small molecular building blocks such as atoms or simple cycles, limiting their effectiveness to…

Machine Learning · Computer Science 2020-04-21 Wengong Jin , Regina Barzilay , Tommi Jaakkola

Graph Neural Networks (GNNs), neural network architectures targeted to learning representations of graphs, have become a popular learning model for prediction tasks on nodes, graphs and configurations of points, with wide success in…

Machine Learning · Computer Science 2022-04-19 Stefanie Jegelka

Graph Neural Networks (GNNs) have been widely adopted for drug discovery with molecular graphs. Nevertheless, current GNNs mainly excel in leveraging short-range interactions (SRI) but struggle to capture long-range interactions (LRI), both…

Machine Learning · Computer Science 2024-04-02 Xuan Li , Zhanke Zhou , Jiangchao Yao , Yu Rong , Lu Zhang , Bo Han

We consider the task of few shot link prediction on graphs. The goal is to learn from a distribution over graphs so that a model is able to quickly infer missing edges in a new graph after a small amount of training. We show that current…

Machine Learning · Computer Science 2020-03-03 Avishek Joey Bose , Ankit Jain , Piero Molino , William L. Hamilton

In this paper we study the practicality and usefulness of incorporating distributed representations of graphs into models within the context of drug pair scoring. We argue that the real world growth and update cycles of drug pair scoring…

Machine Learning · Computer Science 2022-11-28 Paul Scherer , Pietro Liò , Mateja Jamnik

The advent of massive data repositories has propelled machine learning techniques to the front lines of many scientific fields, and exploring new frontiers by leveraging the predictive power of machine learning will greatly accelerate big…

Materials Science · Physics 2020-05-05 Matthew R. Carbone , Mehmet Topsakal , Deyu Lu , Shinjae Yoo

We study how to generate molecule conformations (i.e., 3D structures) from a molecular graph. Traditional methods, such as molecular dynamics, sample conformations via computationally expensive simulations. Recently, machine learning…

Machine Learning · Computer Science 2021-04-01 Minkai Xu , Shitong Luo , Yoshua Bengio , Jian Peng , Jian Tang

Recently, there has been a surge of interest in employing neural networks for graph generation, a fundamental statistical learning problem with critical applications like molecule design and community analysis. However, most approaches…

Machine Learning · Computer Science 2024-07-31 Yunhui Jang , Seul Lee , Sungsoo Ahn

Supervised learning with deep models has tremendous potential for applications in materials science. Recently, graph neural networks have been used in this context, drawing direct inspiration from models for molecules. However, materials…

Materials Science · Physics 2023-01-18 Sékou-Oumar Kaba , Siamak Ravanbakhsh
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