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We consider high-dimensional regression over subgroups of observations. Our work is motivated by biomedical problems, where disease subtypes, for example, may differ with respect to underlying regression models, but sample sizes at the…

Decision tree is an important method for both induction research and data mining, which is mainly used for model classification and prediction. ID3 algorithm is the most widely used algorithm in the decision tree so far. In this paper, the…

Machine Learning · Computer Science 2016-12-02 Singh Vijendra , Hemjyotsana Parashar , Nisha Vasudeva

Artificial intelligence, trained via machine learning or computational statistics algorithms, holds much promise for the improvement of small molecule drug discovery. However, structure-activity data are high dimensional with low…

Applications · Statistics 2018-07-25 Oliver Watson , Isidro Cortes-Ciriano , Aimee Taylor , James A Watson

In this paper, we present a contraction-guided adaptive partitioning algorithm for improving interval-valued robust reachable set estimates in a nonlinear feedback loop with a neural network controller and disturbances. Based on an estimate…

Systems and Control · Electrical Eng. & Systems 2024-01-23 Akash Harapanahalli , Saber Jafarpour , Samuel Coogan

We study the problem of multivariate regression where the data are naturally grouped, and a regression matrix is to be estimated for each group. We propose an approach in which a dictionary of low rank parameter matrices is estimated across…

Machine Learning · Computer Science 2012-07-03 Min Xu , John Lafferty

This paper presents Sparse Partitioning, a Bayesian method for identifying predictors that either individually or in combination with others affect a response variable. The method is designed for regression problems involving binary or…

Quantitative Methods · Quantitative Biology 2011-08-31 Doug Speed , Simon Tavaré

For many kinds of interventions, such as a new advertisement, marketing intervention, or feature recommendation, it is important to target a specific subset of people for maximizing its benefits at minimum cost or potential harm. However, a…

Methodology · Statistics 2020-11-12 Yanbo Xu , Divyat Mahajan , Liz Manrao , Amit Sharma , Emre Kiciman

A compositional tree refers to a tree structure on a set of random variables where each random variable is a node and composition occurs at each non-leaf node of the tree. As a generalization of compositional data, compositional trees…

Methodology · Statistics 2021-04-20 Bingkai Wang , Brian S. Caffo , Xi Luo , Chin-Fu Liu , Andreia V. Faria , Michael I. Miller , Yi Zhao

Model-based recursive partitioning (MOB) and its extension, metaMOB, are potent tools for identifying subgroups with differential treatment effects. In the metaMOB approach random effects are used to model heterogeneity of the treatment…

Methodology · Statistics 2023-11-06 Cynthia Huber , Tim Friede

A decision tree is commonly restricted to use a single hyperplane to split the covariate space at each of its internal nodes. It often requires a large number of nodes to achieve high accuracy, hurting its interpretability. In this paper,…

Machine Learning · Computer Science 2020-10-23 Mohammadreza Armandpour , Mingyuan Zhou

Individual participant data (IPD) meta-analyses of randomised trials are considered a reliable way to assess participant-level treatment effect modifiers but may not make the best use of the available data. Traditionally, effect modifiers…

Decision trees and their ensembles are popular in machine learning as easy-to-understand models. Several techniques have been proposed in the literature for learning tree-based classifiers, with different techniques working well for data…

Machine Learning · Computer Science 2025-05-20 Maria-Florina Balcan , Dravyansh Sharma

In randomized controlled trials, forest plots are frequently used to investigate the homogeneity of treatment effect estimates in subgroups. However, the interpretation of subgroup-specific treatment effect estimates requires great care due…

Methodology · Statistics 2024-07-17 Marcel Wolbers , Mar Vázquez Rabuñal , Ke Li , Kaspar Rufibach , Daniel Sabanés Bové

The increasing complexity of data requires methods and models that can effectively handle intricate structures, as simplifying them would result in loss of information. While several analytical tools have been developed to work with complex…

Methodology · Statistics 2023-06-16 Riccardo Giubilei , Tullia Padellini , Pierpaolo Brutti

We often seek to estimate the causal effect of an exposure on a particular outcome in both randomized and observational settings. One such estimation method is the covariate-adjusted residuals estimator, which was designed for individually…

Methodology · Statistics 2019-10-28 Stephen A. Lauer , Nicholas G. Reich , Laura B. Balzer

We develop Clustered Random Forests, a random forests algorithm for clustered data, arising from independent groups that exhibit within-cluster dependence. The leaf-wise predictions for each decision tree making up clustered random forests…

Methodology · Statistics 2026-01-26 Elliot H. Young , Peter Bühlmann

Tree-structured models are a powerful alternative to parametric regression models if non-linear effects and interactions are present in the data. Yet, classical tree-structured models might not be appropriate if data comes in clusters of…

Methodology · Statistics 2025-01-23 Nikolai Spuck , Matthias Schmid , Moritz Berger

We propose and study a method for learning interpretable representations for the task of regression. Features are represented as networks of multi-type expression trees comprised of activation functions common in neural networks in addition…

Neural and Evolutionary Computing · Computer Science 2019-03-26 William La Cava , Tilak Raj Singh , James Taggart , Srinivas Suri , Jason H. Moore

Balancing influential covariates is crucial for valid treatment comparisons in clinical studies. While covariate-adaptive randomization is commonly used to achieve balance, its performance can be inadequate when the number of baseline…

Methodology · Statistics 2024-12-30 Ziqing Guo , Yang Liu , Lucy Xia

Conversational recommender systems (CRS) dynamically obtain the user preferences via multi-turn questions and answers. The existing CRS solutions are widely dominated by deep reinforcement learning algorithms. However, deep reinforcement…

Information Retrieval · Computer Science 2022-09-01 A S M Ahsan-Ul Haque , Hongning Wang