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Diverse cognitive processes set different demands on locally segregated and globally integrated brain activity. However, it remains unclear how resting brains configure their functional organization to balance the demands on network…

Neurons and Cognition · Quantitative Biology 2022-04-25 Rong Wang , Mianxin Liu , Xinhong Cheng , Ying Wu , Andrea Hildebrandt , Changsong Zhou

Understanding the relation between cortical neuronal network structure and neuronal activity is a fundamental unresolved question in neuroscience, with implications to our understanding of the mechanism by which neuronal networks evolve…

Network control theory (NCT) has recently been utilized in neuroscience to facilitate our understanding of brain stimulation effects. A particularly useful branch of NCT is optimal control, which focuses on applying theoretical and…

Other Quantitative Biology · Quantitative Biology 2025-01-17 Kangli Dong , Siya Chen , Ying Dan , Lu Zhang , Xinyi Li , Wei Liang , Yue Zhao , Yu Sun

Many systems such as critical infrastructure exhibit a modular structure with many links within the modules and few links between them. One approach to increase the robustness of these systems is to reinforce a fraction of the nodes in each…

Physics and Society · Physics 2022-05-11 Yael Kfir-Cohen , Dana Vaknin , Shlomo Havlin

Neural networks are a group of neurons stacked together in multiple layers to mimic the biological neurons in a human brain. Neural networks have been trained using the backpropagation algorithm based on gradient descent strategy for…

Neural and Evolutionary Computing · Computer Science 2025-04-22 Deepak Kumar

Inspired by the prevalence of recurrent circuits in biological brains, we investigate the degree to which directionality is a helpful inductive bias for artificial neural networks. Taking directionality as topologically-ordered information…

Machine Learning · Computer Science 2025-07-22 Yiding Song

The brain is characterized by a strong heterogeneity of inhibitory neurons. We report that spiking neural networks display a resonance to the heterogeneity of inhibitory neurons, with optimal input/output responsiveness occurring for levels…

Neurons and Cognition · Quantitative Biology 2021-09-30 Matteo di Volo , Alain Destexhe

We apply the framework of optimal nonlinear control to steer the dynamics of a whole-brain network of FitzHugh-Nagumo oscillators. Its nodes correspond to the cortical areas of an atlas-based segmentation of the human cerebral cortex, and…

Neurons and Cognition · Quantitative Biology 2021-09-08 Teresa Chouzouris , Nicolas Roth , Caglar Cakan , Klaus Obermayer

The study of control mechanisms of biological systems allows for interesting applications in bioengineering and medicine, for instance in cell reprogramming or drug target identification. A control strategy often consists of a set of…

Molecular Networks · Quantitative Biology 2022-03-28 Laura Cifuentes-Fontanals , Elisa Tonello , Heike Siebert

In the brain, fine-scale correlations combine to produce macroscopic patterns of activity. However, as experiments record from larger and larger populations, we approach a fundamental bottleneck: the number of correlations one would like to…

Biological Physics · Physics 2024-02-02 Christopher W. Lynn , Qiwei Yu , Rich Pang , Stephanie E. Palmer , William Bialek

We consider two optimization problems in which a planner aims to influence the average transient opinion in the Friedkin-Johnsen dynamics on a network by intervening on the agents' innate opinions. Solving these problems requires full…

Physics and Society · Physics 2025-09-04 Leonardo Cianfanelli , Giacomo Como , Fabio Fagnani , Asuman Ozdaglar , Francesca Parise

The brain can efficiently learn a wide range of tasks, motivating the search for biologically inspired learning rules for improving current artificial intelligence technology. Most biological models are composed of point neurons, and cannot…

Neurons and Cognition · Quantitative Biology 2026-04-13 Cristiano Capone , Cosimo Lupo , Paolo Muratore , Pier Stanislao Paolucci

Optimal percolation concerns the identification of the minimum-cost strategy for the destruction of any extensive connected components in a network. Solutions of such a dismantling problem are important for the design of optimal strategies…

Physics and Society · Physics 2022-08-03 Saeed Osat , Fragkiskos Papadopoulos , Andreia Sofia Teixeira , Filippo Radicchi

The emergence of large-scale connectivity underlies the proper functioning of many networked systems, ranging from social networks and technological infrastructure to global trade networks. Percolation theory characterizes network formation…

Physics and Society · Physics 2018-06-20 Malte Schröder , Jan Nagler , Marc Timme , Dirk Witthaut

The network paradigm is increasingly used to describe the dynamics of complex systems. Here we review the current results and propose future development areas in the assessment of perturbation waves, i.e. propagating structural changes in…

Molecular Networks · Quantitative Biology 2009-04-23 Miklos A. Antal , Csaba Bode , Peter Csermely

Periodic pulse train stimulation is generically used to study the function of the nervous system and to counteract disease-related neuronal activity, e.g., collective periodic neuronal oscillations. The efficient control of neuronal…

Adaptation and Self-Organizing Systems · Physics 2020-08-05 Kestutis Pyragas , Augustinas P. Fedaravičius , Tatjana Pyragienė

Influence maximization (IM) is a fundamental problem in complex network analysis, with a wide range of real-world applications. To date, existing approaches to influential node identification in IM have predominantly relied on standard…

Social and Information Networks · Computer Science 2026-04-20 Qianshi Wang , Xilong Qu , Wenbin Pei , Nan Li , Qiang Zhang

A pressing scientific challenge is to understand how brains work. Of particular interest is the neocortex,the part of the brain that is especially large in humans, capable of handling a wide variety of tasks including visual, auditory,…

Neural and Evolutionary Computing · Computer Science 2016-09-03 Peter U. Diehl , Matthew Cook

The integrity and functionality of many real-world complex systems hinge on a small set of pivotal nodes, or influencers. In different contexts, these influencers are defined as either structurally important nodes that maintain the…

Physics and Society · Physics 2019-08-30 Sen Pei , Jiannan Wang , Flaviano Morone , Hernán A Makse

The neural mechanism of memory has a very close relation with the problem of representation in artificial intelligence. In this paper a computational model was proposed to simulate the network of neurons in brain and how they process…

Neurons and Cognition · Quantitative Biology 2020-12-02 Hui Wei