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Super-resolution fluorescence microscopy is of great interest in life science studies for visualizing subcellular structures at the nanometer scale. Among various kinds of super-resolution approaches, image scanning microscopy (ISM) offers…

Much of our progress in understanding microscale biology has been powered by advances in microscopy. For instance, super-resolution microscopes allow the observation of biological structures at near-atomic-scale resolution, while…

Quantum imaging exploits the spatial correlations between photons to image object features with a higher resolution than a corresponding classical light source could achieve. Using a quantum correlated $N$-photon state, the method of…

We propose to use intensity correlation microscopy in combination with structured illumination to image quantum emitters that exhibit antibunching with a spatial resolution reaching far beyond the Rayleigh limit. Combining intensity…

Super-resolution optical microscopy is a rapidly evolving scientific field dedicated to imaging sub-wavelength sized objects, leaving its mark in multiple branches of biology and technology. While several super-resolution optical microscopy…

Quantum sensing exploits quantum phenomena to enhance the detection and estimation of classical parameters of physical systems and biological entities, particularly so as to overcome the inefficiencies of its classical counterparts. A…

Quantum imaging is emerging as a transformative approach for biomedical applications, applying nonclassical properties of light, such as entanglement, squeezing, and quantum correlations, to overcome fundamental limits of conventional…

One of the main characteristics of optical imaging systems is the spatial resolution, which is restricted by the diffraction limit to approximately half the wavelength of the incident light. Along with the recently developed classical…

The optical diffraction limit, formulated by Abbe 140 years ago, imposes a bound on imaging resolution in classical optics. Over the last twenty years, many theoretical schemes have been presented for overcoming the diffraction barrier in…

Quantum Physics · Physics 2013-07-12 O. Schwartz , J. M. Levitt , R. Tenne , S. Itzhakov , Z. Deutsch , D. Oron

Recovering both amplitude and phase information from a system is a fundamental goal of optical imaging. At the same time, it is crucial to operate at low photon doses to avoid altering the sample, particularly in biological applications.…

Quantum Physics · Physics 2026-01-15 Alberto Paniate , Giuseppe Ortolano , Sarika Soman , Marco Genovese , Ivano Ruo-Berchera

The contrast of an image can be degraded by the presence of background light and sensor noise. To overcome this degradation, quantum illumination protocols have been theorised (Science 321 (2008), Physics Review Letters 101 (2008)) that…

Quantum Physics · Physics 2021-09-21 Thomas Gregory , Paul-Antoine Moreau , Ermes Toninelli , Miles J. Padgett

Breaking the diffraction limit in microscopy by utilizing quantum properties of light has been the goal of intense research in the recent years. We propose a quantum superresolution technique based on non-classical emission statistics of…

Optics · Physics 2013-05-30 Osip Schwartz , Dan Oron

In our research, we have developed a novel mechanism that allows for a significant reduction in the smallest sampling unit of digital image sensors (DIS) to as small as 1/16th of a pixel, through measuring the intra-pixel quantum efficiency…

Quantum imaging can potentially provide certain advantages over classical imaging. Thus far, however, the signal-to-noise ratios (SNRs) are poor; the resolvable pixel counts are low; biological organisms have not been imaged; birefringence…

Quantum Physics · Physics 2024-03-13 Yide Zhang , Zhe He , Xin Tong , David C. Garrett , Rui Cao , Lihong V. Wang

Nonlinear optical processes are used in biological microscopy to surpass the diffraction limit on resolution, image deeper into brain tissues, and identify biomolecules without exogenous labels. These techniques typically require high…

Quantitative phase microscopy (QPM), a technique combining phase imaging and microscopy, enables visualization of the 3D topography in reflective samples, as well as the inner structure or refractive index distribution of transparent and…

Optics · Physics 2025-01-17 Vicente Mico , Juanjuan Zheng , Javier Garcia , Zeev Zalevsky , Peng Gao

In recent years, image-scanning microscopy (ISM, also termed pixel-reassignment microscopy) has emerged as a technique that improves the resolution and signal-to-noise compared to confocal and widefield microscopy by employing a detector…

Optics · Physics 2023-04-19 Tal I. Sommer , Gil Weinberg , Ori Katz

Fast and sensitive detector arrays enable image scanning microscopy (ISM), overcoming the trade-off between spatial resolution and signal-to-noise ratio (SNR) typical of confocal microscopy. However, current ISM approaches cannot provide…

One of the challenges of quantum technologies is realising the quantum advantage, predicted for ideal systems, in real applications, which have to cope with decoherence and inefficiencies. In quantum metrology, sub-shot-noise imaging (SSNI)…

Quantum Physics · Physics 2020-06-18 I. Ruo Berchera , A. Meda , E. Losero , A. Avella , N. Samantaray , M. Genovese

For more than a century, the diffraction limit has defined the resolution achievable by passive optical imaging systems. Although some resolution improvement can be gained through classical data processing of the image, it is limited by the…

Quantum Physics · Physics 2026-05-12 A. I. Lvovsky , Michael R. Grace , Saikat Guha , Mankei Tsang , Gerardo Adesso , Nicolas Treps
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