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Magnetic resonance imaging (MRI) offers superior soft tissue contrast and is widely used in biomedicine. However, conventional MRI is not quantitative, which presents a bottleneck in image analysis and digital healthcare. Typically,…

Magnetic resonance imaging (MRI) is a cornerstone of clinical neuroimaging, yet conventional MRIs provide qualitative information heavily dependent on scanner hardware and acquisition settings. While quantitative MRI (qMRI) offers intrinsic…

Quantitative MRI (qMRI) estimates tissue properties of interest from measured MRI signals. This process is conventionally achieved by model fitting, whose computational expense limits qMRI's clinical use, motivating recent development of…

Medical Physics · Physics 2025-10-10 Giulio V. Minore , Louis Dwyer-Hemmings , Timothy J. P. Bray , Hui Zhang

Quantitative susceptibility mapping (QSM) utilizes MRI signal phase to infer estimates of local tissue magnetism (magnetic susceptibility), which has been shown useful to provide novel image contrast and as biomarkers of abnormal tissue.…

Medical Physics · Physics 2019-04-16 Juan Liu , Kevin M. Koch

Quantitative MRI (qMRI) offers significant advantages over weighted images by providing objective parameters related to tissue properties. Deep learning-based methods have demonstrated effectiveness in estimating quantitative maps from…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Shishuai Wang , Hua Ma , Juan A. Hernandez-Tamames , Stefan Klein , Dirk H. J. Poot

Quantitative Magnetic Resonance Imaging (MRI) is based on a two-steps approach: estimation of the magnetic moments distribution inside the body, followed by a voxel-by-voxel quantification of the human tissue properties. This splitting…

We propose a deep learning-based approach that integrates MRI sequence parameters to improve the accuracy and generalizability of quantitative image synthesis from clinical weighted MRI. Our physics-driven neural network embeds MRI sequence…

Image and Video Processing · Electrical Eng. & Systems 2025-08-12 Lingjing Chen , Chengxiu Zhang , Yinqiao Yi , Yida Wang , Yang Song , Xu Yan , Shengfang Xu , Dalin Zhu , Mengqiu Cao , Yan Zhou , Chenglong Wang , Guang Yang

In neuroimaging, MRI tissue properties characterize underlying neurobiology, provide quantitative biomarkers for neurological disease detection and analysis, and can be used to synthesize arbitrary MRI contrasts. Estimating tissue…

Image and Video Processing · Electrical Eng. & Systems 2021-07-07 Divya Varadarajan , Katherine L. Bouman , Andre van der Kouwe , Bruce Fischl , Adrian V. Dalca

Magnetic resonance spectroscopy (MRS) is an important technique in biomedical research and it has the unique capability to give a non-invasive access to the biochemical content (metabolites) of scanned organs. In the literature, the…

Computer Vision and Pattern Recognition · Computer Science 2018-06-20 Nima Hatami , Michaël Sdika , Hélène Ratiney

Biophysical model fitting plays a key role in obtaining quantitative parameters from physiological signals and images. However, the model complexity for molecular magnetic resonance imaging (MRI) often translates into excessive computation…

Medical Physics · Physics 2025-04-18 Alex Finkelstein , Nikita Vladimirov , Moritz Zaiss , Or Perlman

The task of MRI fingerprinting is to identify tissue parameters from complex-valued MRI signals. The prevalent approach is dictionary based, where a test MRI signal is compared to stored MRI signals with known tissue parameters and the most…

Computer Vision and Pattern Recognition · Computer Science 2017-07-04 Patrick Virtue , Stella X. Yu , Michael Lustig

Quantitative MRI (qMRI) methods allow reducing the subjectivity of clinical MRI by providing numerical values on which diagnostic assessment or predictions of tissue properties can be based. However, qMRI measurements typically take more…

Medical Physics · Physics 2022-02-15 Matti Hanhela , Antti Paajanen , Mikko J. Nissi , Ville Kolehmainen

This work addresses the problem of estimating proton density and T1 maps from two partially sampled K-space scans such that the total acquisition time remains approximately the same as a single scan. Existing multi parametric non linear…

Computer Vision and Pattern Recognition · Computer Science 2015-12-25 Anupriya Gogna , Angshul Majumdar

Quantitative magnetic resonance imaging (qMRI) is concerned with estimating (in physical units) values of magnetic and tissue parameters e.g., relaxation times $T_1$, $T_2$, or proton density $\rho$. Recently in [Ma et al., Nature, 2013],…

Optimization and Control · Mathematics 2019-03-29 Guozhi Dong , Michael Hintermüller , Kostas Papafitsoros

Magnetic Resonance Fingerprinting (MRF) and other highly accelerated transient-state parameter mapping techniques enable simultaneous quantification of multiple tissue properties, but often suffer from aliasing artifacts due to compressed…

Quantitative Magnetic Resonance Imaging (qMRI) provides researchers insight into pathological and physiological alterations of living tissue, with the help of which researchers hope to predict (local) therapeutic efficacy early and…

Applications · Statistics 2008-07-30 Xiaoxi Zhang , Timothy D. Johnson , Roderick J. A. Little , Yue Cao

Traditional approaches for molecular imaging of Parkinson's disease (PD) in vivo require radioactive isotopes, lengthy scan times, or deliver only low spatial resolution. Recent advances in saturation transfer-based PD magnetic resonance…

Medical Physics · Physics 2025-12-24 Hagar Shmuely , Michal Rivlin , Or Perlman

Quantitative MRI (qMRI) refers to a class of MRI methods for quantifying the spatial distribution of biological tissue parameters. Traditional qMRI methods usually deal separately with artifacts arising from accelerated data acquisition,…

Image and Video Processing · Electrical Eng. & Systems 2025-02-21 Xiaojian Xu , Weijie Gan , Satya V. V. N. Kothapalli , Dmitriy A. Yablonskiy , Ulugbek S. Kamilov

Magnetic resonance imaging (MRI) is the non-invasive modality of choice for body tissue composition analysis due to its excellent soft tissue contrast and lack of ionizing radiation. However, quantification of body composition requires an…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Ismail Irmakci , Sarfaraz Hussein , Aydogan Savran , Rita R. Kalyani , David Reiter , Chee W. Chia , Kenneth W. Fishbein , Richard G. Spencer , Luigi Ferrucci , Ulas Bagci

Obtaining magnetic resonance images (MRI) with high resolution and generating quantitative image-based biomarkers for assessing tissue biochemistry is crucial in clinical and research applications. How- ever, acquiring quantitative…

Computer Vision and Pattern Recognition · Computer Science 2018-08-15 Akshay Chaudhari , Zhongnan Fang , Jin Hyung Lee , Garry Gold , Brian Hargreaves
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