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High-performance computing (HPC) is reshaping computational drug discovery by enabling large-scale, time-efficient molecular simulations. In this work, we explore HPC-driven pipelines for Alzheimer's disease drug discovery, focusing on…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-03 Paul Ruiz Alliata , Diana Rubaga , Daniel Kumlin , Alberto Puliga

We describe an important addition to the parallel implementation of our generalized NLTE stellar atmosphere and radiative transfer computer program PHOENIX. In a previous paper in this series we described data and task parallel algorithms…

Astrophysics · Physics 2009-10-30 E. Baron , Peter H. Hauschildt

Real-time, energy-efficient inference on edge devices is essential for graph classification across a range of applications. Hyperdimensional Computing (HDC) is a brain-inspired computing paradigm that encodes input features into…

Hardware Architecture · Computer Science 2026-05-19 Jebacyril Arockiaraj , Dhruv Parikh , Viktor Prasanna

Accurate and efficient thermal dynamics models of permanent magnet synchronous motors are vital to efficient thermal management strategies. Physics-informed methods combine model-based and data-driven methods, offering greater flexibility…

Systems and Control · Electrical Eng. & Systems 2025-11-21 Xinyuan Liao , Shaowei Chen , Shuai Zhao

Next-generation supercomputers will feature more hierarchical and heterogeneous memory systems with different memory technologies working side-by-side. A critical question is whether at large scale existing HPC applications and emerging…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-04-27 Ivy Bo Peng , Stefano Markidis , Erwin Laure , Gokcen Kestor , Roberto Gioiosa

As modern HPC computing platforms become increasingly heterogeneous, it is challenging for programmers to fully leverage the computation power of massive parallelism offered by such heterogeneity. Consequently, task-based runtime systems…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-04-05 Yiqing Wang , Xiaoyan Liu , Hailong Yang , Xinyu Yang , Pengbo Wang , Yi Liu , Zhongzhi Luan , Depei Qian

The Simplex tableau has been broadly used and investigated in the industry and academia. With the advent of the big data era, ever larger problems are posed to be solved in ever larger machines whose architecture type did not exist in the…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-05-29 Demetrios Coutinho , Felipe O. Lins e Silva , Daniel Aloise , Samuel , Xavier-de-Souza

Large-scale recommendation systems are pivotal to process an immense volume of daily user interactions, requiring the effective modeling of high cardinality and heterogeneous features to ensure accurate predictions. In prior work, we…

Information Retrieval · Computer Science 2025-08-19 Yue Dong , Han Li , Shen Li , Nikhil Patel , Xing Liu , Xiaodong Wang , Chuanhao Zhuge

MiMiC is a framework for performing multiscale simulations in which loosely coupled external programs describe individual subsystems at different resolutions and levels of theory. To make it highly efficient and flexible, we adopt an…

Task parallelism as employed by the OpenMP task construct, although ideal for tackling irregular problems or typical producer/consumer schemes, bears some potential for performance bottlenecks if locality of data access is important, which…

Performance · Computer Science 2009-02-12 Markus Wittmann , Georg Hager

In this talk I discuss the general question of the portability of Molecular Dynamics codes for diffusive systems on parallel computers of the APE family. The intrinsic single precision arithmetics of the today available APE platforms does…

Biological Physics · Physics 2009-10-30 G. La Penna , S. Letardi , V. Minicozzi , S. Morante , G. C. Rossi , G. Salina

This paper presents a lightweight, open-source and high-performance python package for solving peridynamics problems in solid mechanics. The development of this solver is motivated by the need for fast analysis tools to achieve the large…

Software Engineering · Computer Science 2021-09-15 B. Boys , T. J. Dodwell , M. Hobbs , M. Girolami

The advent of high performance computing (HPC) and graphics processing units (GPU), present an enormous computation resource for Large data transactions (big data) that require parallel processing for robust and prompt data analysis. While…

Distributed, Parallel, and Cluster Computing · Computer Science 2014-10-17 Kato Mivule , Benjamin Harvey , Crystal Cobb , Hoda El Sayed

In the past decade, high performance compute capabilities exhibited by heterogeneous GPGPU platforms have led to the popularity of data parallel programming languages such as CUDA and OpenCL. Such languages, however, involve a steep…

Distributed, Parallel, and Cluster Computing · Computer Science 2020-09-17 Anirban Ghose , Siddharth Singh , Vivek Kulaharia , Lokesh Dokara , Srijeeta Maity , Soumyajit Dey

With increased reliance on cyber infrastructure, large scale power networks face new challenges owing to computational scalability. In this paper we focus on developing an asynchronous decentralized solution framework for the Unit…

Distributed, Parallel, and Cluster Computing · Computer Science 2019-04-15 Paritosh Ramanan , Murat Yildirim , Edmond Chow , Nagi Gebraeel

The simplex algorithm has been successfully used for many years in solving linear programming (LP) problems. Due to the intensive computations required (especially for the solution of large LP problems), parallel approaches have also…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-11-22 Basilis Mamalis , Marios Perlitis

Modern supercomputers are increasingly requiring the presence of accelerators and co-processors. However, it has not been easy to achieve good performance on such heterogeneous clusters. The key challenge has been to ensure good load…

Distributed, Parallel, and Cluster Computing · Computer Science 2013-07-18 Jesse Kelly , Omar Ghattas , Hari Sundar

The recent advancements in multicore machines highlight the need to simplify concurrent programming in order to leverage their computational power. One way to achieve this is by designing efficient concurrent data structures (e.g. stacks,…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-03-31 Nikolaos D. Kallimanis

Machine learning potentials have achieved great success in accelerating atomistic simulations. Many of them relying on atom-centered local descriptors are natural for parallelization. More recent message passing neural network (MPNN) models…

Chemical Physics · Physics 2025-06-10 Junfan Xia , Bin Jiang

Meeting both scalability and performance portability requirements is a challenge for any HPC application, especially for adaptively refined ones. In Octo-Tiger, an astrophysics application for the simulation of stellar mergers, we approach…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-03-07 Gregor Daiß , Patrick Diehl , Dominic Marcello , Alireza Kheirkhahan , Hartmut Kaiser , Dirk Pflüger
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