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Causal discovery, the task of inferring causal structure from data, has the potential to uncover mechanistic insights from biological experiments, especially those involving perturbations. However, causal discovery algorithms over larger…

Machine Learning · Computer Science 2025-04-01 Menghua Wu , Yujia Bao , Regina Barzilay , Tommi Jaakkola

Bayesian networks are probabilistic graphical models with a wide range of application areas including gene regulatory networks inference, risk analysis and image processing. Learning the structure of a Bayesian network (BNSL) from discrete…

Artificial Intelligence · Computer Science 2021-06-24 Fulya Trösser , Simon de Givry , George Katsirelos

Causality is essential for understanding complex systems, such as the economy, the brain, and the climate. Constructing causal graphs often relies on either data-driven or expert-driven approaches, both fraught with challenges. The former…

Artificial Intelligence · Computer Science 2024-06-12 Kai-Hendrik Cohrs , Gherardo Varando , Emiliano Diaz , Vasileios Sitokonstantinou , Gustau Camps-Valls

Despite several advances in recent years, learning causal structures represented by directed acyclic graphs (DAGs) remains a challenging task in high dimensional settings when the graphs to be learned are not sparse. In this paper, we…

Machine Learning · Computer Science 2023-05-16 Zhuangyan Fang , Shengyu Zhu , Jiji Zhang , Yue Liu , Zhitang Chen , Yangbo He

We consider the problem of estimating a large causal polytree from a relatively small i.i.d. sample. This is motivated by the problem of determining causal structure when the number of variables is very large compared to the sample size,…

Methodology · Statistics 2024-08-20 Sourav Chatterjee , Mathukumalli Vidyasagar

Directed acyclic graphs have been used fruitfully to represent causal strucures (Pearl 1988). However, in the social sciences and elsewhere models are often used which correspond both causally and statistically to directed graphs with…

Artificial Intelligence · Computer Science 2020-10-24 Thomas S. Richardson

Causal graphs (CGs) are compact representations of the knowledge of the data generating processes behind the data distributions. When a CG is available, e.g., from the domain knowledge, we can infer the conditional independence (CI)…

Machine Learning · Computer Science 2021-08-18 Takeshi Teshima , Masashi Sugiyama

Directed acyclic graphs (DAGs) are commonly used to represent causal relationships among random variables in graphical models. Applications of these models arise in the study of physical, as well as biological systems, where directed edges…

Machine Learning · Statistics 2009-12-01 Ali Shojaie , George Michailidis

Causal structure learning, also known as causal discovery, aims to estimate causal relationships between variables as a form of a causal directed acyclic graph (DAG) from observational data. One of the major frameworks is the order-based…

Machine Learning · Statistics 2026-02-18 Kentaro Kanamori , Hirofumi Suzuki , Takuya Takagi

Real-life statistical samples are often plagued by selection bias, which complicates drawing conclusions about the general population. When learning causal relationships between the variables is of interest, the sample may be assumed to be…

Statistics Theory · Mathematics 2018-11-15 Angelos P. Armen , Robin J. Evans

One of the common obstacles for learning causal models from data is that high-order conditional independence (CI) relationships between random variables are difficult to estimate. Since CI tests with conditioning sets of low order can be…

Machine Learning · Computer Science 2020-10-07 Marcel Wienöbst , Maciej Liśkiewicz

Directed acyclic graphs are the basic representation of the structure underlying Bayesian networks, which represent multivariate probability distributions. In many practical applications, such as the reverse engineering of gene regulatory…

Computation · Statistics 2013-11-15 Jack Kuipers , Giusi Moffa

In our recent works, we developed a probabilistic framework for structural analysis in undirected networks. The key idea of that framework is to sample a network by a symmetric bivariate distribution and then use that bivariate distribution…

Social and Information Networks · Computer Science 2015-10-19 Cheng-Shang Chang , Duan-Shin Lee , Li-Heng Liou , Sheng-Min Lu , Mu-Huan Wu

Causal discovery methods based on the PC algorithm are proven to be sound if all structural assumptions are fulfilled and all conditional independence tests are correct. This idealized setting is rarely given in real data. In this work, we…

Machine Learning · Statistics 2026-03-19 Sofia Faltenbacher , Jonas Wahl , Rebecca Herman , Jakob Runge

Directed acyclic graphs (DAGs) are commonly used to model causal relationships among random variables. In general, learning the DAG structure is both computationally and statistically challenging. Moreover, without additional information,…

Machine Learning · Statistics 2024-03-26 Ali Shojaie , Wenyu Chen

Causal discovery, the learning of causality in a data mining scenario, has been of strong scientific and theoretical interest as a starting point to identify "what causes what?" Contingent on assumptions and a proper learning algorithm, it…

Methodology · Statistics 2022-05-23 Gabriel Ruiz , Oscar Hernan Madrid Padilla , Qing Zhou

Perturbation experiments allow biologists to discover causal relationships between variables of interest, but the sparsity and high dimensionality of these data pose significant challenges for causal structure learning algorithms.…

Quantitative Methods · Quantitative Biology 2024-10-21 Peiwen Li , Menghua Wu

Recovering the random graph model from an observed collection of networks is known to present significant challenges in the setting, where the networks do not share a common node set and have different sizes. More specifically, the goal is…

Methodology · Statistics 2026-03-17 Roland Boniface Sogan , Tabea Rebafka

Directed acyclic graphs provide a fundamental tool for representing directed dependence structures in multivariate network data, and are widely used to model financial and economic networks. However, accurate and interpretable estimation…

Methodology · Statistics 2026-05-26 Huihang Liu , Wenhui Li , Xinyu Zhang

Probabilistic inferences distill knowledge from graphs to aid human make important decisions. Due to the inherent uncertainty in the model and the complexity of the knowledge, it is desirable to help the end-users understand the inference…

Social and Information Networks · Computer Science 2019-08-21 Chao Chen , Yifei Liu , Xi Zhang , Sihong Xie