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Many events in the vertebrate immune system are influenced by some element of chance. The objective of the present work is to describe affinity maturation of B lymphocytes (in which random events are perhaps the most characteristic), and to…

Molecular Networks · Quantitative Biology 2015-05-05 Tamás Szabados , Gábor Tusnády , László Varga , Tibor Bakács

The decision of whether or not to vaccinate is a complex one. It involves the contribution both to a social good -- herd immunity -- and to one's own well being. It is informed by social influence, personal experience, education, and mass…

Populations and Evolution · Quantitative Biology 2022-02-15 Soya Miyoshi , Marko Jusup , Petter Holme

We consider the problem of designing almost optimal predictors for dynamical systems from a finite sequence of noisy observations and incomplete knowledge of the dynamics and the noise. We first discuss the properties of the optimal (Bayes)…

Chaotic Dynamics · Physics 2007-07-30 Marian Anghel , Ingo Steinwart

In model-based reinforcement learning, generative and temporal models of environments can be leveraged to boost agent performance, either by tuning the agent's representations during training or via use as part of an explicit planning…

This study proposes the novel Bayesian and inverse Bayesian (BIB) inference framework that incorporates symmetry bias into the Bayesian updating process to perform both conventional and inverse Bayesian updates concurrently. Conventional…

The adaptive immune system constantly remodels its lymphocyte repertoire for better protection against future pathogens. Its ability to improve antigen recognition on the fly relies on somatic mutation and selective expansion of B…

Biological Physics · Physics 2022-09-29 Hongda Jiang , Shenshen Wang

We present a spatially-extended system of chemical reactions exhibiting adaptation to time-dependent influxes of reactants. Here adaptation is defined as improved reproductive success, namely the ability of one of the many locally stable…

Statistical Mechanics · Physics 2025-12-02 Olivier Rivoire , Guy Bunin

Imitation learning is an effective alternative approach to learn a policy when the reward function is sparse. In this paper, we consider a challenging setting where an agent and an expert use different actions from each other. We assume…

Machine Learning · Computer Science 2019-08-27 Konrad Zolna , Negar Rostamzadeh , Yoshua Bengio , Sungjin Ahn , Pedro O. Pinheiro

We examine the feasibility of predicting and subsequently managing the future evolution of a Complex Adaptive System. Our archetypal system mimics a competitive population of mechanical, biological, informational or human objects. We show…

Disordered Systems and Neural Networks · Physics 2007-05-23 David M. D. Smith , Neil F. Johnson

In varying environments it is beneficial for organisms to utilize available cues to infer the conditions they may encounter and express potentially favorable traits. However, external cues can be unreliable or too costly to use. We consider…

Populations and Evolution · Quantitative Biology 2023-01-10 Leo Law , BingKan Xue

Neural associative memories are single layer perceptrons with fast synaptic learning typically storing discrete associations between pairs of neural activity patterns. Previous works have analyzed the optimal networks under naive Bayes…

Neural and Evolutionary Computing · Computer Science 2024-12-25 Andreas Knoblauch

Building autonomous -- i.e., choosing goals based on one's needs -- and adaptive -- i.e., surviving in ever-changing environments -- agents has been a holy grail of artificial intelligence (AI). A living organism is a prime example of such…

Artificial Intelligence · Computer Science 2025-03-18 Sungwoo Lee , Younghyun Oh , Hyunhoe An , Hyebhin Yoon , Karl J. Friston , Seok Jun Hong , Choong-Wan Woo

We study a mixed population of adaptive agents with small and large memories, competing in a minority game. If the agents are sufficiently adaptive, we find that the average winnings per agent can exceed that obtainable in the corresponding…

Condensed Matter · Physics 2009-10-31 N. F. Johnson , P. M. Hui , D. Zheng , M. Hart

This paper develops a dynamical framework for adaptive coordination in systems of interacting agents referred to here as Feedback-Coupled Memory Systems (FCMS). Instead of framing coordination as equilibrium optimization or agent-centric…

Multiagent Systems · Computer Science 2026-03-31 Stefano Grassi

The immune system is a complex biological system with a highly distributed, adaptive and self-organising nature. This paper presents an artificial immune system (AIS) that exploits some of these characteristics and is applied to the task of…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Steve Cazyer , Uwe Aickelin

Robots that are trained to perform a task in a fixed environment often fail when facing unexpected changes to the environment due to a lack of exploration. We propose a principled way to adapt the policy for better exploration in changing…

Robotics · Computer Science 2019-05-10 Xingyu Lin , Pengsheng Guo , Carlos Florensa , David Held

The immune system provides an ideal metaphor for anomaly detection in general and computer security in particular. Based on this idea, artificial immune systems have been used for a number of years for intrusion detection, unfortunately so…

Neural and Evolutionary Computing · Computer Science 2010-07-05 Uwe Aickelin , Julie Greensmith

Recently we have used a cellular automata model which describes the dynamics of a multi-connected network to reproduce the refractory behavior and aging effects obtained in immunization experiments performed with mice when subjected to…

Statistical Mechanics · Physics 2007-05-23 Mauro Copelli , Rita M. Zorzenon dos Santos , Daniel A. Stariolo

One strategy for winning a coevolutionary struggle is to evolve rapidly. Most of the literature on host-pathogen coevolution focuses on this phenomenon, and looks for consequent evidence of coevolutionary arms races. An alternative…

Populations and Evolution · Quantitative Biology 2014-12-17 Erick Chastain , Rustom Antia , Carl T. Bergstrom

Despite the obvious advantage of simple life forms capable of fast replication, different levels of cognitive complexity have been achieved by living systems in terms of their potential to cope with environmental uncertainty. Against the…

Populations and Evolution · Quantitative Biology 2017-10-18 Luís F Seoane , Ricard Solé