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Inference of species networks from genomic data under the Network Multispecies Coalescent Model is currently severely limited by heavy computational demands. It also remains unclear how complicated networks can be for consistent inference…

Populations and Evolution · Quantitative Biology 2022-05-10 Elizabeth S. Allman , Hector Baños , Jonathan D. Mitchell , John A. Rhodes

The standard approach to estimate species trees is to align a selected set of genes, concatenate the alignments and then estimate a consensus tree. However, individual genes contain differing levels of evolutionary information, either…

Populations and Evolution · Quantitative Biology 2021-11-29 Ali Amiryousefi

Decision trees and random forest remain highly competitive for classification on medium-sized, standard datasets due to their robustness, minimal preprocessing requirements, and interpretability. However, a single tree suffers from high…

Machine Learning · Statistics 2025-12-02 Cencheng Shen , Yuexiao Dong , Carey E. Priebe

Gene tree/species tree reconciliation is a recent decisive progress in phylo-genetic methods, accounting for the possible differences between gene histories and species histories. Reconciliation consists in explaining these differences by…

Quantitative Methods · Quantitative Biology 2017-10-05 Damir Hasic , Eric Tannier

In phylogenomics, species-tree methods must contend with two major sources of noise; stochastic gene-tree variation under the multispecies coalescent model (MSC) and finite-sequence substitutional noise. Fast agglomerative methods such as…

Populations and Evolution · Quantitative Biology 2025-07-11 Georgios Aliatimis , Ruriko Yoshida , Burak Boyaci , James A. Grant

Agreement forests continue to play a central role in the comparison of phylogenetic trees since their introduction more than 25 years ago. More specifically, they are used to characterise several distances that are based on tree…

Combinatorics · Mathematics 2025-09-23 Steven Kelk , Simone Linz , Charles Semple

Phylogenetic trees summarize evolutionary relationships between organisms, and tools to analyze collections of phylogenetic trees enable contrasts between different genes' ancestry. The BHV metric space has enabled the analysis of…

Quantitative Methods · Quantitative Biology 2026-04-24 Maria Alejandra Valdez Cabrera , Amy D Willis

Evolutionary events such as incomplete lineage sorting and lateral gene transfer constitute major problems for inferring species trees from gene trees, as they can sometimes lead to gene trees which conflict with the underlying species…

Populations and Evolution · Quantitative Biology 2013-04-23 Andreas Sand , Mike Steel

A method was developed for Bayesian inference of species phylogeny using the multi-species coalescent model. To improve the mixing properties of the Markov chain Monte Carlo (MCMC) algorithm that traverses the space of species trees, we…

Populations and Evolution · Quantitative Biology 2015-12-15 Bruce Rannala , Ziheng Yang

One can often make inferences about a growing network from its current state alone. For example, it is generally possible to determine how a network changed over time or pick among plausible mechanisms explaining its growth. In practice,…

Social and Information Networks · Computer Science 2021-01-27 George T. Cantwell , Guillaume St-Onge , Jean-Gabriel Young

Phylogenetic inference, the task of reconstructing how related sequences evolved from common ancestors, is a central objective in evolutionary genomics. The current state-of-the-art methods exploit probabilistic models of sequence evolution…

Populations and Evolution · Quantitative Biology 2026-02-19 Luc Blassel , Noémie Sauvage , Pierre Barrat-Charlaix , Bastien Boussau , Nicolas Lartillot , Laurent Jacob

Supertree methods are tree reconstruction techniques that combine several smaller gene trees (possibly on different sets of species) to build a larger species tree. The question of interest is whether the reconstructed supertree converges…

Populations and Evolution · Quantitative Biology 2021-05-06 Lam Si Tung Ho , Vu Dinh

Pathogen genome data offers valuable structure for spatial models, but its utility is limited by incomplete sequencing coverage. We propose a probabilistic framework for inferring genetic distances between unsequenced cases and known…

Genomics · Quantitative Biology 2025-09-10 Haley Stone , Jing Du , Hao Xue , Matthew Scotch , David Heslop , Andreas Züfle , Chandini Raina MacIntyre , Flora Salim

Computational inference of dated evolutionary histories relies upon various hypotheses about RNA, DNA, and protein sequence mutation rates. Using mutation rates to infer these dated histories is referred to as molecular clock assumption.…

Populations and Evolution · Quantitative Biology 2021-01-11 Lena Collienne , Kieran Elmes , Mareike Fischer , David Bryant , Alex Gavryushkin

Comparisons of single-cell RNA sequencing (scRNA-seq) data across species can reveal links between cellular gene expression and the evolution of cell functions, features, and phenotypes. These comparisons invoke evolutionary histories, as…

Populations and Evolution · Quantitative Biology 2023-07-07 Samuel H. Church , Jasmine L. Mah , Casey W. Dunn

Motivation: Millions of genes in the modern species belong to only thousands of `gene families'. A gene family includes instances of the same gene in different species (orthologs) and duplicate genes in the same species (paralogs). Genes…

Populations and Evolution · Quantitative Biology 2012-05-04 Yu Zheng , Taoyang Wu , Louxin Zhang

Reconciling gene trees with a species tree is a fundamental problem to understand the evolution of gene families. Many existing approaches reconcile each gene tree independently. However, it is well-known that the evolution of gene families…

Populations and Evolution · Quantitative Biology 2018-06-12 Riccardo Dondi , Manuel Lafond , Celine Scornavacca

Distances on merge trees facilitate visual comparison of collections of scalar fields. Two desirable properties for these distances to exhibit are 1) the ability to discern between scalar fields which other, less complex topological…

Computational Geometry · Computer Science 2022-10-18 Brian Bollen , Pasindu Tennakoon , Joshua A. Levine

The reconstruction of a central tendency `species tree' from a large number of conflicting gene trees is a central problem in systematic biology. Moreover, it becomes particularly problematic when taxon coverage is patchy, so that not all…

Populations and Evolution · Quantitative Biology 2013-07-22 Mike Steel

Phylogenetic networks are a type of directed acyclic graph that represent how a set $X$ of present-day species are descended from a common ancestor by processes of speciation and reticulate evolution. In the absence of reticulate evolution,…

Combinatorics · Mathematics 2017-08-11 Andrew Francis , Charles Semple , Mike Steel
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