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Convolutional Neural Networks (CNNs) are powerful models that achieve impressive results for image classification. In addition, pre-trained CNNs are also useful for other computer vision tasks as generic feature extractors. This paper aims…

Computer Vision and Pattern Recognition · Computer Science 2015-07-10 Ben Athiwaratkun , Keegan Kang

Increasing evidence suggests that chromosome folding and genetic expression are intimately connected. For example, the co-expression of a large number of genes can benefit from their spatial co-localization in the cellular space.…

Soft Condensed Matter · Physics 2018-03-13 Guillaume Le Treut

The three-dimensional organization of chromatin is thought to play an important role in controlling gene expression. Specificity in expression is achieved through the interaction of transcription factors and other nuclear proteins with…

Biological Physics · Physics 2025-07-22 Mason N. Rouches , Benjamin B. Machta

Network analysis is a powerful way of modeling chromatin interactions. Assortativity is a network property used in social sciences to identify factors affecting how people establish social ties. We propose a new approach, using chromatin…

Currently, increasingly deeper neural networks have been applied to improve their accuracy. In contrast, We propose a novel wider Convolutional Neural Networks (CNN) architecture, motivated by the Multi-column Deep Neural Networks and the…

Computer Vision and Pattern Recognition · Computer Science 2018-10-10 Xiaobo Huang

In medicine, visualizing chromosomes is important for medical diagnostics, drug development, and biomedical research. Unfortunately, chromosomes often overlap and it is necessary to identify and distinguish between the overlapping…

Computer Vision and Pattern Recognition · Computer Science 2017-12-21 R. Lily Hu , Jeremy Karnowski , Ross Fadely , Jean-Patrick Pommier

Current research in Computer Vision has shown that Convolutional Neural Networks (CNN) give state-of-the-art performance in many classification tasks and Computer Vision problems. The embedding of CNN, which is the internal representation…

Computer Vision and Pattern Recognition · Computer Science 2015-08-04 Axel Angel

Predicting DNA-protein binding is an important and classic problem in bioinformatics. Convolutional neural networks have outperformed conventional methods in modeling the sequence specificity of DNA-protein binding. However, none of the…

Genomics · Quantitative Biology 2021-06-04 Yuhang Guo , Xiao Luo , Liang Chen , Minghua Deng

Deep neural networks have demonstrated superior performance in artificial intelligence applications, but the opaqueness of their inner working mechanism is one major drawback in their application. The prevailing unit-based interpretation is…

Computer Vision and Pattern Recognition · Computer Science 2024-02-29 Lei Lyu , Chen Pang , Jihua Wang

The 3D folding of a mammalian gene can be studied by a polymer model, where the chromatin fibre is represented by a semiflexible polymer which interacts with multivalent proteins, representing complexes of DNA-binding transcription factors…

Biological Physics · Physics 2023-12-20 Andrea Bonato , Dom Corbett , Sergey Kitaev , Davide Marenduzzo , Alexander Morozov , Enzo Orlandini

Interpreting the decision logic behind effective deep convolutional neural networks (CNN) on images complements the success of deep learning models. However, the existing methods can only interpret some specific decision logic on individual…

Computer Vision and Pattern Recognition · Computer Science 2021-08-24 Peter Cho-Ho Lam , Lingyang Chu , Maxim Torgonskiy , Jian Pei , Yong Zhang , Lanjun Wang

Deep convolutional neural networks have proven their effectiveness, and have been acknowledged as the most dominant method for image classification. However, a severe drawback of deep convolutional neural networks is poor explainability.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-27 Bin Wang , Wenbin Pei , Bing Xue , Mengjie Zhang

In this work we describe a Convolutional Neural Network (CNN) to accurately predict the scene illumination. Taking image patches as input, the CNN works in the spatial domain without using hand-crafted features that are employed by most…

Computer Vision and Pattern Recognition · Computer Science 2015-04-20 Simone Bianco , Claudio Cusano , Raimondo Schettini

Three-Dimensional (3D) chromatin interactions, such as enhancer-promoter interactions (EPIs), loops, Topologically Associating Domains (TADs), and A/B compartments play critical roles in a wide range of cellular processes by regulating gene…

Genomics · Quantitative Biology 2024-03-07 Brydon P. G. Wall , My Nguyen , J. Chuck Harrell , Mikhail G. Dozmorov

Convolutional neural networks for computer vision are fairly intuitive. In a typical CNN used in image classification, the first layers learn edges, and the following layers learn some filters that can identify an object. But CNNs for…

Computation and Language · Computer Science 2018-04-04 Prudhvi Raj Dachapally , Srikanth Ramanam

Non protein coding regions of the human genome contain many complex patterns which regulate the cellular activity. Studying the human genome is limited by the lack of understanding of its features and their complex interactions. However,…

Genomics · Quantitative Biology 2017-08-15 Kerim Arioglu , Umut Eser

Selecting appropriate datasets is critical in modern computer vision. However, no general-purpose tools exist to evaluate the extent to which two datasets differ. For this, we propose representing images - and by extension datasets - using…

Computer Vision and Pattern Recognition · Computer Science 2023-04-21 Benjamin Ramtoula , Matthew Gadd , Paul Newman , Daniele De Martini

The graph structure is a commonly used data storage mode, and it turns out that the low-dimensional embedded representation of nodes in the graph is extremely useful in various typical tasks, such as node classification, link prediction ,…

Social and Information Networks · Computer Science 2020-08-03 Xing Li , Wei Wei , Xiangnan Feng , Xue Liu , Zhiming Zheng

Convolutional neural networks rely on image texture and structure to serve as discriminative features to classify the image content. Image enhancement techniques can be used as preprocessing steps to help improve the overall image quality…

Computer Vision and Pattern Recognition · Computer Science 2018-03-30 Vivek Sharma , Ali Diba , Davy Neven , Michael S. Brown , Luc Van Gool , Rainer Stiefelhagen

Convolutional Neural Networks (CNNs) are build specifically for computer vision tasks for which it is known that the input data is a hierarchical structure based on locally correlated elements. The question that naturally arises is what…

Computer Vision and Pattern Recognition · Computer Science 2019-07-26 Cristian Ivan