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Markov state models (MSMs) have been demonstrated to be a powerful method for computationally studying intramolecular processes such as protein folding and macromolecular conformational changes. In this article, we present a new approach to…

Biological Physics · Physics 2015-06-18 Matthew R. Perkett , Michael F. Hagan

Hidden Markov Models (HMMs) have become very popular as a computational tool for the analysis of sequential data. They are memoryless machines which transition from one internal state to another, while producing symbols. These symbols…

Quantum Physics · Physics 2012-10-01 Ben O`Neill , Tom M. Barlow , Dominik Safranek , Almut Beige

We study finite-state controllers (FSCs) for partially observable Markov decision processes (POMDPs) that are provably correct with respect to given specifications. The key insight is that computing (randomised) FSCs on POMDPs is equivalent…

Logic in Computer Science · Computer Science 2018-07-18 Sebastian Junges , Nils Jansen , Ralf Wimmer , Tim Quatmann , Leonore Winterer , Joost-Pieter Katoen , Bernd Becker

We extend the formalism of pure state thermodynamics to matrix product states. In pure state thermodynamics finite temperature properties of quantum systems are derived without the need of statistical mechanics ensembles, but instead using…

Quantum Physics · Physics 2013-10-31 Silvano Garnerone

The chemical master equation (CME) is frequently used in systems biology to quantify the effects of stochastic fluctuations that arise due to biomolecular species with low copy numbers. The CME is a system of ordinary differential equations…

Quantitative Methods · Quantitative Biology 2017-10-25 Ankit Gupta , Jan Mikelson , Mustafa Khammash

There is presently considerable interest in accurately simulating the evolution of open systems for which Markovian master equations fail. Examples are systems that are time-dependent and/or strongly damped. A number of elegant methods have…

Quantum Physics · Physics 2014-04-23 Luciano Silvestri , Kurt Jacobs , Vanja Dunjko , Maxim Olshanii

Steady-state quantum thermal machines are typically characterized by a continuous flow of heat between different reservoirs. However, at the level of discrete stochastic realizations, heat flow is unraveled as a series of abrupt quantum…

Quantum Physics · Physics 2025-06-05 Abhaya S. Hegde , Patrick P. Potts , Gabriel T. Landi

Continuous-time stochastic processes pervade everyday experience, and the simulation of models of these processes is of great utility. Classical models of systems operating in continuous-time must typically track an unbounded amount of…

Quantum Physics · Physics 2018-03-05 Thomas J. Elliott , Mile Gu

By considering general Markov stochastic dynamics and its coarse-graining, we study the framework of stochastic thermodynamics for the original and reduced descriptions corresponding to different scales. We are especially concerned with the…

Statistical Mechanics · Physics 2015-01-29 Yohei Nakayama , Kyogo Kawaguchi

Markov state models (MSMs) have been successful in computing metastable states, slow relaxation timescales and associated structural changes, and stationary or kinetic experimental observables of complex molecules from large amounts of…

Chemical Physics · Physics 2015-06-17 Frank Noe , Hao Wu , Jan-Hendrik Prinz , Nuria Plattner

We define an infinite stochastic state machine, the Battery-Discharge-Model (BDM), which simulates the behaviour of linear and jump complexity of the continued fraction expansion of multidimensional formal power series, a relevant security…

Information Theory · Computer Science 2007-07-13 Michael Vielhaber , Monica del Pilar Canales

Hopfield attractor networks are robust distributed models of human memory, but lack a general mechanism for effecting state-dependent attractor transitions in response to input. We propose construction rules such that an attractor network…

Neural and Evolutionary Computing · Computer Science 2024-05-03 Madison Cotteret , Hugh Greatorex , Martin Ziegler , Elisabetta Chicca

The bisimulation metric (BSM) is a powerful tool for computing state similarities within a Markov decision process (MDP), revealing that states closer in BSM have more similar optimal value functions. While BSM has been successfully…

Machine Learning · Computer Science 2025-11-04 Zhenyu Tao , Wei Xu , Xiaohu You

We consider stochastic thermodynamics as a theory of statistical inference for experimentally observed fluctuating time-series. To that end, we introduce a general framework for quantifying the knowledge about the dynamical state of the…

Statistical Mechanics · Physics 2015-05-19 Bernhard Altaner , Jürgen Vollmer

Finite state machines (FSMs) are widely used to manage robot behavior logic, particularly in real-world applications that require a high degree of reliability and structure. However, traditional manual FSM design and modification processes…

Robotics · Computer Science 2024-12-10 Xiangyu Robin Gan , Yuxin Ray Song , Nick Walker , Maya Cakmak

Modern state-space models (SSMs) often utilize transition matrices which enable efficient computation but pose restrictions on the model's expressivity, as measured in terms of the ability to emulate finite-state automata (FSA). While…

Artificial Intelligence · Computer Science 2025-12-17 Aleksandar Terzić , Nicolas Menet , Michael Hersche , Thomas Hofmann , Abbas Rahimi

In this paper, we consider statistical estimation of time-inhomogeneous aggregate Markov models. Unaggregated models, which corresponds to Markov chains, are commonly used in multi-state life insurance to model the biometric states of an…

Statistics Theory · Mathematics 2023-08-11 Jamaal Ahmad , Mogens Bladt

(abridged) In this paper, we present the issues we consider as essential as far as the statistical mechanics of finite systems is concerned. In particular, we emphasis our present understanding of phase transitions in the framework of…

Statistical Mechanics · Physics 2012-02-20 P. Chomaz , F. Gulminelli

Markov state models (MSMs) are a powerful tool to analyze and coarse-grain complex dynamical data into interpretable kinetic processes. This capability is particularly important in heterogeneous catalysis, where a medley of reactants and…

Statistical Mechanics · Physics 2026-05-11 Caitlin A. McCandler , Chatipat Lorpaiboon , Timothy C. Berkelbach , Jutta Rogal

Finite-state reasoning, the ability to understand and implement state-dependent behavior, is central to hardware design. In this paper, we present LLM-FSM, a benchmark that evaluates how well large language models (LLMs) can recover…

Artificial Intelligence · Computer Science 2026-02-10 Yuheng Wu , Berk Gokmen , Zhouhua Xie , Peijing Li , Caroline Trippel , Priyanka Raina , Thierry Tambe