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Cancer survival prediction is an active area of research that can help prevent unnecessary therapies and improve patient's quality of life. Gene expression profiling is being widely used in cancer studies to discover informative biomarkers…

Machine Learning · Computer Science 2016-11-18 Hamid Reza Hassanzadeh , John H. Phan , May D. Wang

Background: High-throughput techniques bring novel tools but also statistical challenges to genomic research. Identifying genes with differential expression between different species is an effective way to discover evolutionarily conserved…

Methodology · Statistics 2018-10-05 Yan Zhou , Jiadi Zhu , Tiejun Tong , Junhui Wang , Bingqing Lin , Jun Zhang

Recent powerful pre-trained language models have achieved remarkable performance on most of the popular datasets for reading comprehension. It is time to introduce more challenging datasets to push the development of this field towards more…

Computation and Language · Computer Science 2020-08-25 Weihao Yu , Zihang Jiang , Yanfei Dong , Jiashi Feng

Acute lymphoblastic leukaemia (ALL) is a blood malignancy that mainly affects adults and children. This study looks into the use of deep learning, specifically Convolutional Neural Networks (CNNs), for the detection and classification of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-11 Sabit Ahamed Preanto , Md. Taimur Ahad , Yousuf Rayhan Emon , Sumaya Mustofa , Md Alamin

Electrocardiogram (ECG) diagnosis remains challenging due to limited labeled data and the need to capture subtle yet clinically meaningful variations in rhythm and morphology. We present CREMA (Contrastive Regularized Masked Autoencoder), a…

Machine Learning · Computer Science 2025-08-22 Junho Song , Jong-Hwan Jang , DongGyun Hong , Joon-myoung Kwon , Yong-Yeon Jo

Lymphoma diagnosis, particularly distinguishing between subtypes, is critical for effective treatment but remains challenging due to the subtle morphological differences in histopathological images. This study presents a novel hybrid deep…

Image and Video Processing · Electrical Eng. & Systems 2024-10-10 Salah A. Aly , Ali Bakhiet , Mazen Balat

Efficient code retrieval is critical for developer productivity, yet existing benchmarks largely focus on Python and rarely stress-test robustness beyond superficial lexical cues. To address the gap, we introduce an automated pipeline for…

Software Engineering · Computer Science 2026-03-06 Kaicheng Wang , Liyan Huang , Weike Fang , Weihang Wang

Recent explainability related studies have shown that state-of-the-art DNNs do not always adopt correct evidences to make decisions. It not only hampers their generalization but also makes them less likely to be trusted by end-users. In…

Machine Learning · Computer Science 2019-08-16 Mengnan Du , Ninghao Liu , Fan Yang , Xia Hu

The explosive growth of system logs makes streaming compression essential, yet existing log anomaly detection (LAD) methods incur severe pre-processing overhead by requiring full decompression and parsing. We introduce CLAD, the first deep…

Machine Learning · Computer Science 2026-04-15 Benzhao Tang , Shiyu Yang

Retrieval-Augmented Generation (RAG) delivers substantial value in knowledge-intensive applications. However, its generated responses often lack transparent reasoning paths that trace back to source evidence from retrieved documents. This…

Computation and Language · Computer Science 2026-01-30 Jingyi Ren , Yekun Xu , Xiaolong Wang , Weitao Li , Ante Wang , Weizhi Ma , Yang Liu

The main challenge in de novo assembly of NGS data is certainly to deal with repeats that are longer than the reads. This is particularly true for RNA- seq data, since coverage information cannot be used to flag repeated sequences, of which…

Data Structures and Algorithms · Computer Science 2014-06-05 Gustavo Sacomoto , Blerina Sinaimeri , Camille Marchet , Vincent Miele , Marie-France Sagot , Vincent Lacroix

Late diagnosis and high costs are key factors that negatively impact the care of cancer patients worldwide. Although the availability of biological markers for the diagnosis of cancer type is increasing, costs and reliability of tests…

Machine Learning · Computer Science 2019-08-20 Sterling Ramroach , Melford John , Ajay Joshi

Intracavitary atrial electrograms (EGMs) provide high-resolution insights into cardiac electrophysiology but are often contaminated by noise and remain high-dimensional, limiting real-time analysis. We introduce CLARAE (CLArity-preserving…

We present a novel method for automated identification of putative cell types from single-cell RNA-seq (scRNA-seq) data. By iteratively applying a machine learning approach to an initial clustering of gene expression profiles of a given set…

Quantitative Methods · Quantitative Biology 2020-04-22 Zhichao Miao , Pablo Moreno , Ni Huang , Irene Papatheodorou , Alvis Brazma , Sarah A Teichmann

Deep learning (DL) has recently drawn much attention in image analysis, natural language process, and high-dimensional medical data analysis. Under the causal direct acyclic graph (DAG) interpretation, the input variables without incoming…

Applications · Statistics 2022-03-22 Jong-Hyeon Jeong , Yichen Jia

Single-cell RNA sequencing (scRNA-seq) data analysis is pivotal for understanding cellular heterogeneity. However, the high sparsity and complex noise patterns inherent in scRNA-seq data present significant challenges for traditional…

Genomics · Quantitative Biology 2024-08-13 Wenwen Min , Zhen Wang , Fangfang Zhu , Taosheng Xu , Shunfang Wang

Single-cell RNA sequencing (scRNA-seq) has made significant strides in unraveling the intricate cellular diversity within complex tissues. This is particularly critical in the brain, presenting a greater diversity of cell types than other…

Machine Learning · Computer Science 2023-10-05 Gyutaek Oh , Baekgyu Choi , Inkyung Jung , Jong Chul Ye

Gene expression analysis is a critical method for cancer classification, enabling precise diagnoses through the identification of unique molecular signatures associated with various tumors. Identifying cancer-specific genes from gene…

Quantitative Methods · Quantitative Biology 2024-10-11 Farzana Tabassum , Sabrina Islam , Siana Rizwan , Masrur Sobhan , Tasnim Ahmed , Sabbir Ahmed , Tareque Mohmud Chowdhury

Existing deep active learning algorithms achieve impressive sampling efficiency on natural language processing tasks. However, they exhibit several weaknesses in practice, including (a) inability to use uncertainty sampling with black-box…

Computation and Language · Computer Science 2020-07-22 Haw-Shiuan Chang , Shankar Vembu , Sunil Mohan , Rheeya Uppaal , Andrew McCallum

Legal professionals need to write analyses that rely on citations to relevant precedents, i.e., previous case decisions. Intelligent systems assisting legal professionals in writing such documents provide great benefits but are challenging…

Computation and Language · Computer Science 2024-06-28 Abe Bohan Hou , Orion Weller , Guanghui Qin , Eugene Yang , Dawn Lawrie , Nils Holzenberger , Andrew Blair-Stanek , Benjamin Van Durme
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