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X-ray phase-contrast imaging can provide greatly improved contrast over conventional absorption-based imaging for weakly absorbing samples, such as biological soft tissues and fibre composites. In this manuscript, we introduce an easy and…

Software Engineering · Computer Science 2015-04-21 Shenghao Wang , Huajie Han , Kun Gao , Zhili Wang , Can Zhang , Meng Yang , Zhao Wu , Augusto Marcelli , Ziyu Wu

In the hard X rays domain, the phase shift of the wave passing through the soft materials like tissues is typically three orders of magnitude larger than the absorption. Therefore the phase-sensitive X-ray imaging methods can obtain…

Instrumentation and Detectors · Physics 2018-06-12 Lian Chen , Rongqi Sun , Ge Jin

X-ray micro tomography is a non-destructive, three-dimensional inspection technique applied across a vast range of fields and disciplines, ranging from research to industrial, encompassing engineering, biology and medical research.…

X-ray imaging, traditionally relying on attenuation contrast, struggles to differentiate materials with similar attenuation coefficients like soft tissues. X-ray phase contrast imaging (XPCI) and dark-field (DF) imaging provide enhanced…

Medical Physics · Physics 2025-06-05 Jingcheng Yuan , Mini Das

Contrast transfer mechanisms for electron scattering have been extensively studied in transmission electron microscopy. Here we revisit H. Rose's generalized contrast formalism from scattering theory to understand where information is…

Optics · Physics 2025-10-28 Desheng Ma , Guanxing Li , David A Muller , Steven E Zeltmann

Biological soft tissues encountered in clinical and pre-clinical imaging mainly consist of light element atoms, and their composition is nearly uniform with little density variation. Thus, x-ray attenuation imaging suffers from low image…

Medical Physics · Physics 2011-06-28 Wenxiang Cong , Atsushi Momose , Ge Wang

We present a multi-aperture analyser set-up for performing X-ray phase contrast imaging in planar and three-dimensional modalities. A multi-slice representation of the sample is used to establish a quantitative relation between projection…

Instrumentation and Detectors · Physics 2017-06-21 M. Endrizzi , F. A. Vittoria , L. Rigon , D. Dreossi , A. Olivo

X-ray phase contrast imaging holds great promise for improving the visibility of light-element materials such as soft tissues and tumors. Single-mask differential phase contrastnimaging method stands out as a simple and effective approach…

Image and Video Processing · Electrical Eng. & Systems 2024-02-02 Jingcheng Yuan , Mini Das

Phase Contrast Imaging (PCI), Dark-Field (DF) and Directional Dark-Field (DDF) imaging are recent X-ray imaging modalities that have demonstrated their interest by providing access to information and contrasts different from those provided…

Image and Video Processing · Electrical Eng. & Systems 2023-04-25 Clara Magnin , Laurene Quenot , Sylvain Bohic , Dan Mihai Cenda , Manuel Fernández Martínez , Blandine Lantz , Bertrand Faure , Emmanuel Brun

X-ray phase contrast imaging offers a way to visualize the internal structures of an object without the need to deposit any radiation, and thereby alleviate the main concern in x-ray diagnostic imaging procedures today. Grating-based…

Low image contrast is a major limitation in transmission electron microscopy, since samples with low atomic number only weakly phase-modulate the illuminating electron beam, and beam-induced sample damage limits the usable electron dose.…

Instrumentation and Detectors · Physics 2024-03-19 Jeremy J. Axelrod

A new method is developed for three-dimensional (3D) reconstruction of multi-material objects using propagation-based X-ray phase-contrast tomography (PB-CT) with phase retrieval via the contrast transfer function (CTF) formalism. The…

Medical Physics · Physics 2023-05-15 Darren A. Thompson , Yakov I. Nesterets , Konstantin M. Pavlov , Timur E. Gureyev

Medical differential phase contrast x-ray imaging (DPCI) promises improved soft-tissue contrast at lower x-ray dose. The dose strongly depends on both the angular sensitivity and on the visibility of a grating-based Talbot-Lau…

Medical Physics · Physics 2016-03-23 Oliver Preusche

In order to efficiently image a non-absorbing sample (a phase object), dedicated phase contrast optics are required. Typically, these optics are designed with the assumption that the sample is weakly scattering, implying a linear relation…

Optics · Physics 2020-10-22 Stewart Koppell , Mark Kasevich

We propose an imaging system and methodology for mapping soft-tissue samples in three dimensions, with micron-scale and isotropic spatial resolution, with low-concentrations as well as in the absence of heavy metal staining. We used hard…

Instrumentation and Detectors · Physics 2023-12-21 Michela Esposito , Nicole Schieber , Alessandro Olivo , Yannick Schwab , Marco Endrizzi

Phase-contrast imaging is an emerging technology that may increase the signal-difference-to-noise ratio in medical imaging. One of the most promising phase-contrast techniques is Talbot interferometry, which, combined with energy-sensitive…

Scanning transmission electron microscopy (STEM) provides high-resolution visualization of atomic structures as well as various functional imaging modes utilizing phase contrast. In this study we introduce a semicircular aperture in STEM…

As a multi-contrast X-ray computed tomography (CT) imaging system, the grating-based Talbot-Lau interferometer is able to generate the absorption contrast and differential phase contrast (DPC) images concurrently. However, experiments found…

Medical Physics · Physics 2024-04-16 Yuhang Tan , Jiecheng Yang , Hairong Zheng , Dong Liang , Peiping Zhu , Yongshuai Ge

For decades since the development of phase-contrast optical microscopy, an analogous approach has been sought for maximizing the image contrast of weakly-scattering objects in transmission electron microscopy (TEM). The recent development…

In this work, a general theoretical framework is presented to explain the formation of the phase signal in an X-ray microscope integrated with a grating interferometer, which simultaneously enables the high spatial resolution imaging and…

Optics · Physics 2022-09-28 Jiecheng Yang , Yongshuai Ge , Dong Liang , Hairong Zheng
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