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Motor-driven intracellular transport of organelles, vesicles, and other molecular cargo is a highly collective process. An individual cargo is often pulled by a team of transport motors, with numbers ranging from only a few to several…

Statistical Mechanics · Physics 2022-01-06 Matthew P. Leighton , David A. Sivak

Motivated by various recent experimental findings, we propose a dynamical model of intermittently self-propelled particles: active particles that recurrently switch between two modes of motion, namely an active run-state and a turn state,…

Soft Condensed Matter · Physics 2025-10-30 Agniva Datta , Carsten Beta , Robert Großmann

Continuous time random walks combining diffusive and ballistic regimes are introduced to describe a class of L\'evy walks on lattices. By including exponentially-distributed waiting times separating the successive jump events of a walker,…

Statistical Mechanics · Physics 2014-12-02 Giampaolo Cristadoro , Thomas Gilbert , Marco Lenci , David P. Sanders

Cells are strongly out-of-equilibrium systems driven by continuous energy supply. They carry out many vital functions requiring active transport of various ingredients and organelles, some being small, others being large. The cytoskeleton,…

Biological Physics · Physics 2017-09-20 Cecile Appert-Rolland , Maximilian Ebbinghaus , Ludger Santen

The inertia of trapping and detrapping of nonequilibrium charge carriers affects the electrochemical and transport properties of both bulk and nanoscopic structures in a very peculiar way. An emerging memory response with a hysteresis in…

Materials Science · Physics 2023-04-10 Victor Lopez-Richard , Rafael Schio Wengenroth Silva , Ovidiu Lipan , Fabian Hartmann

We present a continuous time random walk model for the scale-invariant transport found in a self-organized critical rice pile [Christensen et al., Phys. Rev. Lett. 77, 107 (1996)]. From our analytical results it is shown that the dynamics…

Condensed Matter · Physics 2016-08-31 Marian Boguna , Alvaro Corral

We present the results of a numerical investigation of charged-particle transport across a synthesized magnetic configuration composed of a constant homogeneous background field and a multiscale perturbation component simulating an effect…

Statistical Mechanics · Physics 2007-05-23 Francesco Chiaravalloti , Alexander V. Milovanov , Gaetano Zimbardo

We propose and analyze a mathematical model of cargo transport by non-processive molecular motors. In our model, the motors change states by random discrete events (corresponding to stepping and binding/unbinding), while the cargo position…

Subcellular Processes · Quantitative Biology 2018-09-28 Christopher E. Miles , Sean D. Lawley , James P. Keener

Advective trapping occurs when solute enters low velocity zones in heterogeneous porous media. Classical local modeling approaches combine the impact of slow advection and diffusion into a hydrodynamic dispersion coefficient and many…

Fluid Dynamics · Physics 2020-12-02 Juan J. Hidalgo , Insa Neuweiler , Marco Dentz

Most cells possess the capacity to locomote. Alone or collectively, this allows them to adapt, to rearrange, and to explore their surroundings. The biophysical characterization of such motile processes, in health and disease, has so far…

Biological Physics · Physics 2021-05-05 Vincent E. Debets , Liesbeth M. C. Janssen , Cornelis Storm

Anomalously slow passive diffusion, $\langle \delta x^2(t)\rangle\simeq t^{\alpha}$, with $0<\alpha<1$, of larger tracers such as messenger RNA and endogenous submicron granules in the cytoplasm of living biological cells has been…

Biological Physics · Physics 2014-09-24 Igor Goychuk , Vasyl O. Kharchenko , Ralf Metzler

Dense bacterial suspensions display collective motion exhibiting coherent flow structures reminiscent of turbulent flows. In contrast to inertial turbulence, understanding the microscopic dynamics of bacterial fluid elements undergoing…

Soft Condensed Matter · Physics 2023-07-28 G. Dhananjay , M. Hemlata , Saravanan Matheshwaran , Sivasurender Chandran

We consider a particle performing a stochastic motion on a one-dimensional lattice with jump widths distributed according to a power-law with exponent $\mu + 1$. Assuming that the walker moves in the presence of a distribution $a(x)$ of…

Statistical Mechanics · Physics 2016-02-02 Luca Cattivelli , Elena Agliari , Fabio Sartori , Davide Cassi

Motor-driven cargo transport is a complex phenomenon where multiple motor proteins attached on to a cargo engage in pulling activity, often leading to tug-of-war, displaying bidirectional motion. However, most mathematical and computational…

Biological Physics · Physics 2016-09-09 Deepak Bhat , Manoj Gopalakrishnan

The analysis of glioblastoma (GB) cell locomotion and its modeling inspired by Levy random walks is presented herein. We study such walks occurring on a two-dimensional plane where the walk is similar to the motion of a bird flying with a…

L\'evy walks are found in the migratory behaviour patterns of various organisms, and the reason for this phenomenon has been much discussed. We use simulations to demonstrate that learning causes the changes in confidence level during…

The L\'evy walk process for a lower interval of an excursion times distribution ($\alpha<1$) is discussed. The particle rests between the jumps and the waiting time is position-dependent. Two cases are considered: a rising and diminishing…

Statistical Mechanics · Physics 2018-06-25 A. Kamińska , T. Srokowski

Many cellular processes rely on the cell's ability to transport material to and from the nucleus. Networks consisting of many microtubules and actin filaments are key to this transport. Recently, the inhibition of intracellular transport…

Subcellular Processes · Quantitative Biology 2020-05-06 Shawn D. Ryan , Zachary McCarthy , Mykhailo Potomkin

Transport of molecular motors along protein filaments in a half-closed geometry is a common feature of biologically relevant processes in cellular protrusions. Using a lattice gas model we study how the interplay between active and…

Biological Physics · Physics 2017-03-30 Isabella R. Graf , Erwin Frey

In living cells, motor proteins, such as kinesin and dynein can move processively along microtubule (MT), and also detach from or attach to MT stochastically. Experiments have found that, the traffic of motor might be jammed, and various…

Biological Physics · Physics 2015-03-06 Yunxin Zhang