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The asymmetric stem-cell division of Drosophila SOP precursor cells is driven by the asymmetric localisation of the key protein Lgl (Lethal giant larvae) during mitosis, when Lgl is phosphorylated by the kinase aPKC on a subpart of the…

Analysis of PDEs · Mathematics 2015-12-18 Tang Quoc Bao , Klemens Fellner , Stefan Rosenberger

The Cellular Potts Model (CPM) is a robust, cell-level methodology for simulation of biological tissues and morphogenesis. Both tissue physiology and morphogenesis depend on diffusion of chemical morphogens in the extra-cellular fluid or…

Biological Physics · Physics 2007-05-23 Debasis Dan , Chris Mueller , Kun Chen , James A. Glazier

Synaptic transmission between neurons is governed by a cascade of stochastic reaction-diffusion events that lead to calcium-induced vesicle release of neurotransmitter. Since experimental measurements of such systems are challenging due…

Biological Physics · Physics 2021-10-14 Maria Reva , David A. DiGregorio , Denis S. Grebenkov

A method for detecting intrinsic slow variables in high-dimensional stochastic chemical reaction networks is developed and analyzed. It combines anisotropic diffusion maps (ADM) with approximations based on the chemical Langevin equation…

Computational Engineering, Finance, and Science · Computer Science 2015-04-09 Mihai Cucuringu , Radek Erban

Reaction-diffusion models have been used over decades to study biological systems. In this context, evolution equations for probability distribution functions and the associated stochastic differential equations have nowadays become…

Statistical Mechanics · Physics 2018-10-09 C. Escudero , S. B. Yuste , E. Abad , F. Le Vot

Computational systems biology has provided plenty of insights into cell biology. Early on, the focus was on reaction networks between molecular species. Spatial distribution only began to be considered mostly within the last decade.…

Quantitative Methods · Quantitative Biology 2016-05-13 Atsushi Miyauchi , Kazunari Iwamoto , Satya Nanda Vel Arjunan , Koichi Takahashi

We present the spatial regime conversion method (SRCM), a novel hybrid modelling framework for simulating reaction-diffusion systems that adaptively combines stochastic discrete and deterministic continuum representations. Extending the…

Quantitative Methods · Quantitative Biology 2025-07-08 Charles G. Cameron , Cameron A. Smith , Christian A. Yates

This paper is concerned with the large deviation principle of the stochastic reaction-diffusion lattice systems defined on the N-dimensional integer set, where the nonlinear drift term is locally Lipschitz continuous with polynomial growth…

Dynamical Systems · Mathematics 2023-05-12 Bixiang Wang

Lattice Boltzmann method (LBM) is particularly well-suited for implementation on quantum circuits owing to its simple algebraic operations and natural parallelism. However, most quantum LBMs fix $\tau$ = 1 to avoid nonlinear collision,…

Quantum Physics · Physics 2025-05-19 Yang Xiao , Liming Yang , Chang Shu , Yinjie Du , Hao Dong , Jie Wu

Many physical systems are described by probability distributions that evolve in both time and space. Modeling these systems is often challenging to due large state space and analytically intractable or computationally expensive dynamics. To…

Biological Physics · Physics 2019-07-03 Oliver K. Ernst , Tom Bartol , Terrence Sejnowski , Eric Mjolsness

It has been established that there is an inherent limit to the accuracy of the reaction-diffusion master equation. Specifically, there exists a fundamental lower bound on the mesh size, below which the accuracy deteriorates as the mesh is…

Numerical Analysis · Mathematics 2016-01-27 Stefan Hellander , Linda Petzold

We address the problem of fine-tuning diffusion models for reward-guided generation in biomolecular design. While diffusion models have proven highly effective in modeling complex, high-dimensional data distributions, real-world…

Reaction-diffusion systems, which consist of the reacting particles subject to diffusion process, constitute one of the common examples of non-linear statistical systems. In low space dimensions $d \leq 2$ the usual description by means of…

Statistical Mechanics · Physics 2023-10-24 Michal Hnatič , Matej Kecer , Tomáš Lučivjanský

We study the steady state of a stochastic particle system on a two-dimensional lattice, with particle influx, diffusion and desorption, and the formation of a dimer when particles meet. Surface processes are thermally activated, with…

Statistical Mechanics · Physics 2015-05-30 A. Wolff , I. Lohmar , J. Krug , O. Biham

The diffusion of a particle in a crowded environment typically proceeds through three regimes: for very short times the particle diffuses freely until it collides with an obstacle for the first time, while for very long times diffusion the…

Biological Physics · Physics 2019-10-09 Nguiya P. Neo , Gary W. Slater

A new upscaling procedure that provides 1D representations of 2D mixing-limited reactive transport systems is developed and applied. A key complication with upscaled models in this setting is that the procedure must differentiate between…

Fluid Dynamics · Physics 2022-10-05 Ricardo H. Deucher , Louis J. Durlofsky

This study delves into the connection between machine learning and lattice field theory by linking generative diffusion models (DMs) with stochastic quantization, from a stochastic differential equation perspective. We show that DMs can be…

High Energy Physics - Lattice · Physics 2023-11-08 Lingxiao Wang , Gert Aarts , Kai Zhou

Several different methods exist for efficient approximation of paths in multiscale stochastic chemical systems. Another approach is to use bursts of stochastic simulation to estimate the parameters of a stochastic differential equation…

Numerical Analysis · Mathematics 2014-12-19 Simon Cotter , Radek Erban

We present a combined analytical and numerical approach based on the Mori projection operator formalism and Monte Carlo simulations to study surface diffusion within the lattice-gas model. In the present theory, the average jump rate and…

Soft Condensed Matter · Physics 2009-10-30 T. Hjelt , I. Vattulainen , J. Merikoski , T. Ala-Nissila , S. C. Ying

A upscaled lattice Boltzmann method (LBM) for flow simulations in heterogeneous porous media, at both pore and Darcy scales, is proposed in this paper. In the micro-scale simulations, we model flows using LBM with the modified Guo et al.…

Computational Physics · Physics 2013-12-03 Jun Li , Donald Brown
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