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In nonclinical pharmaceutical development, tolerance intervals are critical in ensuring product and process quality. They are statistical intervals designed to contain a specified proportion of the population with a given confidence level.…

Methodology · Statistics 2025-12-03 Seokjun Choi , Tony Pourmohamad , Bruno Sansó

Wearable devices permit the continuous monitoring of biological processes, such as blood glucose metabolism, and behavior, such as sleep quality and physical activity. The continuous monitoring often occurs in epochs of 60 seconds over…

Methodology · Statistics 2024-04-23 Yuanyuan Luan , Roger S. Zoh , Erjia Cui , Xue Lan , Sneha Jadhav , Carmen D. Tekwe

Elastic Riemannian metrics have been used successfully in the past for statistical treatments of functional and curve shape data. However, this usage has suffered from an important restriction: the function boundaries are assumed fixed and…

Methodology · Statistics 2021-05-19 Darshan Bryner , Anuj Srivastava

The identification of causal effects in observational studies typically relies on two standard assumptions: unconfoundedness and overlap. However, both assumptions are often questionable in practice: unconfoundedness is inherently…

Methodology · Statistics 2025-09-17 Han Cui , Xinran Li

A functional risk curve gives the probability of an undesirable event as a function of the value of a critical parameter of a considered physical system. In several applicative situations, this curve is built using phenomenological…

Statistics Theory · Mathematics 2017-07-26 Bertrand Iooss , Loïc Le Gratiet

Equivalence testing for scalar data has been well addressed in the literature, however, the same cannot be said for functional data. The resultant complexity from maintaining the functional structure of the data, rather than using a scalar…

Applications · Statistics 2015-03-05 Colin B. Fogarty , Dylan S. Small

We consider functional outlier detection from a geometric perspective, specifically: for functional data sets drawn from a functional manifold which is defined by the data's modes of variation in amplitude and phase. Based on this manifold,…

Machine Learning · Statistics 2021-09-15 Moritz Herrmann , Fabian Scheipl

Statistical analysis of high-dimensional functional times series arises in various applications. Under this scenario, in addition to the intrinsic infinite-dimensionality of functional data, the number of functional variables can grow with…

Statistics Theory · Mathematics 2022-01-14 Qin Fang , Shaojun Guo , Xinghao Qiao

We present an extension to the robust phase estimation protocol, which can identify incorrect results that would otherwise lie outside the expected statistical range. Robust phase estimation is increasingly a method of choice for…

We review and contrast frequentist and Bayesian definitions of tolerance regions. We give conditions under which for large samples a Bayesian region also has frequentist validity, and study the latter for smaller samples in a simulation…

Methodology · Statistics 2022-09-20 X. Gregory Chen , Aad van der Vaart

Variational inference is a general approach for approximating complex density functions, such as those arising in latent variable models, popular in machine learning. It has been applied to approximate the maximum likelihood estimator and…

Methodology · Statistics 2018-04-19 Yen-Chi Chen , Y. Samuel Wang , Elena A. Erosheva

This work presents a fault-tolerant control scheme for sensory faults in robotic manipulators based on active inference. In the majority of existing schemes, a binary decision of whether a sensor is healthy (functional) or faulty is made…

Robotics · Computer Science 2022-03-30 Mohamed Baioumy , Corrado Pezzato , Carlos Hernandez Corbato , Nick Hawes , Riccardo Ferrari

Studying the effects of one-way variation of any number of parameters on any number of output probabilities quickly becomes infeasible in practice, especially if various evidence profiles are to be taken into consideration. To provide for…

Artificial Intelligence · Computer Science 2012-07-09 Silja Renooij , Linda C. van der Gaag

In this paper, we focus on the problem of statistical dependence estimation using characteristic functions. We propose a statistical dependence measure, based on the maximum-norm of the difference between joint and product-marginal…

Machine Learning · Computer Science 2022-08-18 Povilas Daniušis , Shubham Juneja , Lukas Kuzma , Virginijus Marcinkevičius

Wombling methods, first introduced in 1951, have been widely applied to detect boundaries and variations across spatial domains, particularly in biological, public health and meteorological studies. Traditional applications focus on…

Methodology · Statistics 2025-02-12 Luke A. Barratt , John A. D. Aston

The Frequency Response Functions (FRFs) are the most widely used functions to characterise the dynamic behaviour of structures. The natural frequencies and damping behaviour can be easily and quickly detected from a Bode diagram. The modal…

Classical Physics · Physics 2024-04-09 Dario Di Maio

In this paper, a two-step strategy for parametric sensitivity analysis for such systems is proposed, exploiting advantages and synergies between two recently proposed sensitivity analysis methodologies for stochastic dynamics. The first…

Molecular Networks · Quantitative Biology 2016-02-17 Georgios Arampatzis , Markos A. Katsoulakis , Yannis Pantazis

Functional data analysis is ubiquitous in most areas of sciences and engineering. Several paradigms are proposed to deal with the dimensionality problem which is inherent to this type of data. Sparseness, penalization, thresholding, among…

Methodology · Statistics 2018-09-05 Rodney V. Fonseca , Aluísio Pinheiro

Global sensitivity metrics are essential tools for assessing parameter importance in complex models, particularly when precise information about parameter values is unavailable. In many cases, such metrics are used to provide parameter…

Statistics Theory · Mathematics 2025-11-19 Huiyan Zou , Allison L. Lewis

This paper is motivated by medical studies in which the same patients with multiple sclerosis are examined at several successive visits and described by fractional anisotropy tract profiles, which can be represented as functions. Since the…

Methodology · Statistics 2023-06-07 Katarzyna Kuryło , Łukasz Smaga