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We review some recent coarse-graining and multi-scale methods, but also put forward some new ideas for addressing such issues. We find that, if one is guided by nonequilibrium statistical mechanics and thermodynamics, it is possible to…

Soft Condensed Matter · Physics 2009-11-06 Patrick Ilg , Vlasis Mavrantzas , Hans Christian Öttinger

Thermoplastic starch (TPS) is an excellent film-forming material, and adding fillers such as tetramethylammonium-montmorillonite (TMA-MMT) clay has significantly expanded its use in packaging applications. We first used all-atom (AA)…

Soft Condensed Matter · Physics 2024-06-11 Ankit Patidar , Gaurav Goel

For optimal processing and design of entangled polymeric materials it is important to establish a rigorous link between the detailed molecular composition of the polymer and the viscoelastic properties of the macroscopic melt. We review…

Soft Condensed Matter · Physics 2015-05-27 J. T. Padding , W. J. Briels

Even though atomistic and coarse-grained (CG) models have been used to simulate liquid nanodroplets in vapor, very few rigorous studies of the liquid-liquid interface structure are available, and most of them are limited to planar…

Chemical Physics · Physics 2019-07-16 Peiyuan Gao , Xiu Yang , Alexandre M. Tartakovsky

The properties of soft electronic materials depend on the coupling of electronic and conformational degrees of freedom over a wide range of spatiotemporal scales. Description of such properties requires multiscale approaches capable of, at…

Soft Condensed Matter · Physics 2023-07-19 Riccardo Alessandri , Juan J. de Pablo

Coarse graining (CG) enables the investigation of molecular properties for larger systems and at longer timescales than the ones attainable at the atomistic resolution. Machine learning techniques have been recently proposed to learn CG…

Computational Physics · Physics 2022-09-28 Eleonora Ricci , George Giannakopoulos , Vangelis Karkaletsis , Doros N. Theodorou , Niki Vergadou

We propose a highly coarse-grained simulation model for crystalline polymer solids with crystalline lamellar structures. The mechanical properties of a crystalline polymer solid are mainly determined by the crystalline lamellar structures.…

Soft Condensed Matter · Physics 2025-01-13 Takashi Uneyama

We extend our previously developed coarse-graining strategy for linear polymers with a tunable number n of effective atoms (blobs) per chain [D'Adamo et al., J. Chem. Phys. 137, 4901 (2012)] to polymer systems in thermal crossover between…

Soft Condensed Matter · Physics 2014-11-07 Giuseppe D'Adamo , Andrea Pelissetto , Carlo Pierleoni

Coarse-grained (CG) modeling enables molecular simulations to reach time and length scales inaccessible to fully atomistic methods. For classical CG models, the choice of mapping, that is, how atoms are grouped into CG sites, is a major…

Chemical Physics · Physics 2025-12-10 Franz Görlich , Julija Zavadlav

Increasing the efficiency of materials design and discovery remains a significant challenge, especially given the prohibitively large size of chemical compound space. The use of a chemically transferable coarse-grained model enables…

Chemical Physics · Physics 2020-01-08 Kiran H. Kanekal , Tristan Bereau

We implemented a coarse-graining procedure to construct mesoscopic models of complex molecules. The final aim is to obtain better results on properties depending on slow modes of the molecules. Therefore the number of particles considered…

Soft Condensed Matter · Physics 2009-10-31 Hendrik Meyer , Oliver Biermann , Roland Faller , Dirk Reith , Florian Mueller-Plathe

Coarse-graining (CG) enables molecular dynamics (MD) simulations of larger systems and longer timescales that are otherwise infeasible with atomistic models. Machine learning potentials (MLPs), with their capacity to capture many-body…

Chemical Physics · Physics 2025-12-01 Weilong Chen , Franz Görlich , Paul Fuchs , Julija Zavadlav

A mesoscopic coarse-grain model for computationally-efficient simulations of biomembranes is presented. It combines molecular dynamics simulations for the lipids, modeled as elastic chains of beads, with multiparticle collision dynamics for…

Soft Condensed Matter · Physics 2015-06-04 Mu-Jie Huang , Raymond Kapral , Alexander S. Mikhailov , Hsuan-Yi Chen

This thesis introduces a framework that is able to describe general many-body coarse-grained interactions. We make use of this to describe the free energy surface as a cluster expansion in terms of monomer, dimer, and trimer terms. The…

Soft Condensed Matter · Physics 2017-09-29 S. T. John

Coarse-grained (CG) models provide an effective route to reducing the complexity of molecular simulations (MD), but conventional approaches depend heavily on long all-atom MD trajectories to adequately sample configurational space. This…

Chemical Physics · Physics 2025-10-28 Maximilian Stupp , P. S. Koutsourelakis

Short fiber reinforced polymer composites have found extensive industrial and engineering applications owing to their unique combination of low cost, relatively easy processing and superior mechanical properties compared to their parent…

Computational Physics · Physics 2017-04-06 Atiyeh Alsadat Mousavi , Behrouz Arash , Xiaoying Zhuang , Timon Rabczuk

The structure of polyelectrolytes is highly sensitive to small changes in the interactions between its monomers. In particular, interactions mediated by counterions play a significant role, and are affected by both specific molecular…

Soft Condensed Matter · Physics 2020-02-03 Pauline Bacle , Marie Jardat , Virginie Marry , Guillaume Mériguet , Guillaume Batôt , Vincent Dahirel

We systematically studied the validity and transferability of effective, coarse-grained, pair potentials in ultrasoft colloidal systems. We focused on amphiphilic dendrimers, macromolecules which can aggregate into clusters of overlapping…

Soft Condensed Matter · Physics 2018-02-01 Marta Montes-Saralegui , Gerhard Kahl , Arash Nikoubashman

Coarse-Graining (CG) models are low resolution approximation of high resolution models, such as all-atomic (AA) models. An effective CG model is expected to reproduce equilibrium values of sufficient physical quantities of its AA model,…

Statistical Mechanics · Physics 2015-02-10 Shijing Lu , Xin Zhou

Bottom-up coarse-grained (CG) modeling expands the spatial and temporal scales of molecular simulation by seeking a reduced, thermodynamically consistent representation of an atomistic model. Developments in CG theory have largely focused…

Chemical Physics · Physics 2025-03-28 Patrick G. Sahrmann , Gregory A. Voth