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We demonstrate that a deep neural network can significantly improve optical microscopy, enhancing its spatial resolution over a large field-of-view and depth-of-field. After its training, the only input to this network is an image acquired…

Machine Learning · Computer Science 2017-11-21 Yair Rivenson , Zoltan Gorocs , Harun Gunaydin , Yibo Zhang , Hongda Wang , Aydogan Ozcan

The combination of tomographic imaging and deep learning, or machine learning in general, promises to empower not only image analysis but also image reconstruction. The latter aspect is considered in this perspective article with an…

Quantitative Methods · Quantitative Biology 2016-11-07 Ge Wang

Microscopy image enhancement plays a pivotal role in understanding the details of biological cells and materials at microscopic scales. In recent years, there has been a significant rise in the advancement of microscopy image enhancement,…

Image and Video Processing · Electrical Eng. & Systems 2025-09-29 Debasish Dutta , Neeharika Sonowal , Risheraj Barauh , Deepjyoti Chetia , Sanjib Kr Kalita

Through digital imaging, microscopy has evolved from primarily being a means for visual observation of life at the micro- and nano-scale, to a quantitative tool with ever-increasing resolution and throughput. Artificial intelligence, deep…

This article reviews deep learning applications in biomedical optics with a particular emphasis on image formation. The review is organized by imaging domains within biomedical optics and includes microscopy, fluorescence lifetime imaging,…

Optical microscopy is an indispensable tool in life sciences research, but conventional techniques require compromises between imaging parameters like speed, resolution, field-of-view, and phototoxicity. To overcome these limitations,…

Quantitative Methods · Quantitative Biology 2024-04-01 Leonor Morgado , Estibaliz Gómez-de-Mariscal , Hannah S. Heil , Ricardo Henriques

Super-resolution microscopy overcomes the diffraction limit of conventional light microscopy in spatial resolution. By providing novel spatial or spatio-temporal information on biological processes at nanometer resolution with molecular…

Biological Physics · Physics 2021-11-10 Tianjie Yang , Yaoru Luo , Wei Ji , Ge Yang

Deep learning is transforming most areas of science and technology, including electron microscopy. This review paper offers a practical perspective aimed at developers with limited familiarity. For context, we review popular applications of…

Image and Video Processing · Electrical Eng. & Systems 2021-03-09 Jeffrey M. Ede

Biomedical photoacoustic tomography, which can provide high resolution 3D soft tissue images based on the optical absorption, has advanced to the stage at which translation from the laboratory to clinical settings is becoming possible. The…

Image and Video Processing · Electrical Eng. & Systems 2020-11-20 Andreas Hauptmann , Ben Cox

Deep learning has transformed the way large and complex image datasets can be processed, reshaping what is possible in bioimage analysis. As the complexity and size of bioimage data continues to grow, this new analysis paradigm is becoming…

Quantitative Methods · Quantitative Biology 2021-08-03 Adrien Hallou , Hannah Yevick , Bianca Dumitrascu , Virginie Uhlmann

This literature review will discuss the use of deep learning methods for image reconstruction using fMRI data. More specifically, the quality of image reconstruction will be determined by the choice in decoding and reconstruction…

Computer Vision and Pattern Recognition · Computer Science 2021-08-10 Madison Van Horn

Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images. This paper reviews the major deep learning concepts pertinent to medical image analysis and summarizes…

Recently, deep learning approaches have become the main research frontier for biological image reconstruction and enhancement problems thanks to their high performance, along with their ultra-fast inference times. However, due to the…

Image and Video Processing · Electrical Eng. & Systems 2022-03-18 Mehmet Akçakaya , Burhaneddin Yaman , Hyungjin Chung , Jong Chul Ye

Magnetic resonance imaging (MRI) is renowned for its exceptional soft tissue contrast and high spatial resolution, making it a pivotal tool in medical imaging. The integration of deep learning algorithms offers significant potential for…

Image and Video Processing · Electrical Eng. & Systems 2024-06-06 Wanyu Bian

Deep learning has received extensive research interest in developing new medical image processing algorithms, and deep learning based models have been remarkably successful in a variety of medical imaging tasks to support disease detection…

Computer Vision and Pattern Recognition · Computer Science 2022-04-12 Xuxin Chen , Ximin Wang , Ke Zhang , Kar-Ming Fung , Theresa C. Thai , Kathleen Moore , Robert S. Mannel , Hong Liu , Bin Zheng , Yuchen Qiu

Deep learning has become a prominent computational modeling tool in the areas of computer vision and image processing in recent years. This research comprehensively analyzes the different deep-learning methods used for image-to-image…

Image and Video Processing · Electrical Eng. & Systems 2023-03-17 Yuda Bi

Optical tweezers exploit light--matter interactions to trap particles ranging from single atoms to micrometer-sized eukaryotic cells. For this reason, optical tweezers are a ubiquitous tool in physics, biology, and nanotechnology. Recently,…

Recent works have shown that learned models can achieve significant performance gains, especially in terms of perceptual quality measures, over traditional methods. Hence, the state of the art in image restoration and compression is getting…

Image and Video Processing · Electrical Eng. & Systems 2021-05-03 A. Murat Tekalp , Michele Covell , Radu Timofte , Chao Dong

Medical imaging is crucial in modern clinics to guide the diagnosis and treatment of diseases. Medical image reconstruction is one of the most fundamental and important components of medical imaging, whose major objective is to acquire…

Image and Video Processing · Electrical Eng. & Systems 2022-10-04 Haimiao Zhang , Bin Dong

Medical imaging is an invaluable resource in medicine as it enables to peer inside the human body and provides scientists and physicians with a wealth of information indispensable for understanding, modelling, diagnosis, and treatment of…

Image and Video Processing · Electrical Eng. & Systems 2022-08-25 Hanene Ben Yedder , Ben Cardoen , Ghassan Hamarneh
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