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Despite the versatility of generalized linear mixed models in handling complex experimental designs, they often suffer from misspecification and convergence problems. This makes inference on the values of coefficients problematic. To…

Methodology · Statistics 2025-03-31 Angela Andreella , Jelle Goeman , Jesse Hemerik , Livio Finos

Electronic health records (EHR) are characterized as non-stationary, heterogeneous, noisy, and sparse data; therefore, it is challenging to learn the regularities or patterns inherent within them. In particular, sparseness caused mostly by…

Machine Learning · Computer Science 2020-03-03 Eunji Jun , Ahmad Wisnu Mulyadi , Jaehun Choi , Heung-Il Suk

High complexity models are notorious in machine learning for overfitting, a phenomenon in which models well represent data but fail to generalize an underlying data generating process. A typical procedure for circumventing overfitting…

Machine Learning · Statistics 2025-03-11 James Schmidt

We consider functional linear regression models where functional outcomes are associated with scalar predictors by coefficient functions with shape constraints, such as monotonicity and convexity, that apply to sub-domains of interest. To…

Methodology · Statistics 2025-05-09 Kyunghee Han , Yeonjoo Park , Soo-Young Kim

We study the estimation capacity of the generalized Lasso, i.e., least squares minimization combined with a (convex) structural constraint. While Lasso-type estimators were originally designed for noisy linear regression problems, it has…

Statistics Theory · Mathematics 2019-09-12 Martin Genzel , Gitta Kutyniok

In recent years the ultrahigh dimensional linear regression problem has attracted enormous attentions from the research community. Under the sparsity assumption most of the published work is devoted to the selection and estimation of the…

Methodology · Statistics 2013-05-01 Randy C. S. Lai , Jan Hannig , Thomas C. M. Lee

Functional data analysis is proved to be useful in many scientific applications. The physical process is observed as curves and often there are several curves observed due to multiple subjects, providing the replicates in statistical sense.…

Methodology · Statistics 2018-01-30 Tapabrata Maiti , Abolfazl Safikhani , Ping-Shou Zhong

Causal inference is a critical research area with multi-disciplinary origins and applications, ranging from statistics, computer science, economics, psychology to public health. In many scientific research, randomized experiments provide a…

Methodology · Statistics 2022-07-26 Jingying Zeng

We investigate the problem of selecting features for datasets that can be naturally partitioned into subgroups (e.g., according to socio-demographic groups and age), each with its own dominant set of features. Within this subgroup-oriented…

Machine Learning · Computer Science 2024-12-10 Bar Genossar , Thinh On , Md. Mouinul Islam , Ben Eliav , Senjuti Basu Roy , Avigdor Gal

Data privacy concerns have led to the growing interest in synthetic data, which strives to preserve the statistical properties of the original dataset while ensuring privacy by excluding real records. Recent advances in deep neural networks…

Methodology · Statistics 2025-07-15 Nir Keret , Ali Shojaie

Assessing fit in common factor models solely through the lens of mean and covariance structures, as is commonly done with conventional goodness-of-fit (GOF) assessments, may overlook critical aspects of misfit, potentially leading to…

Methodology · Statistics 2026-03-04 Youjin Sung , Youngjin Han , Yang Liu

Motivated by the challenges in analyzing gut microbiome and metagenomic data, this work aims to tackle the issue of measurement errors in high-dimensional regression models that involve compositional covariates. This paper marks a…

Methodology · Statistics 2024-09-13 Huali Zhao , Tianying Wang

Irregular errors such as heteroscedasticity and nonnormality remain major challenges in linear modeling. These issues often lead to biased inference and unreliable measures of uncertainty. Classical remedies, such as robust standard errors…

Methodology · Statistics 2026-03-05 Elsayed Elamir

The functional linear model is an important extension of the classical regression model allowing for scalar responses to be modeled as functions of stochastic processes. Yet, despite the usefulness and popularity of the functional linear…

Methodology · Statistics 2025-11-27 Ioannis Kalogridis , Stanislav Nagy

We consider estimation under model misspecification where there is a model mismatch between the underlying system, which generates the data, and the model used during estimation. We propose a model misspecification framework which enables a…

Signal Processing · Electrical Eng. & Systems 2023-02-22 Martin Hellkvist , Ayça Özçelikkale , Anders Ahlén

In order for clinicians to manage disease progression and make effective decisions about drug dosage, treatment regimens or scheduling follow up appointments, it is necessary to be able to identify both short and long-term trends in…

Quantitative Methods · Quantitative Biology 2016-12-06 Norman Poh , Simon Bull , Santosh Tirunagari , Nicholas Cole , Simon de Lusignan

This study proposes a risk prediction method based on a Multi-Scale Temporal Alignment Network (MSTAN) to address the challenges of temporal irregularity, sampling interval differences, and multi-scale dynamic dependencies in Electronic…

Machine Learning · Computer Science 2025-11-27 Wei-Chen Chang , Lu Dai , Ting Xu

Finding general evaluation metrics for unsupervised representation learning techniques is a challenging open research question, which recently has become more and more necessary due to the increasing interest in unsupervised methods. Even…

Computer Vision and Pattern Recognition · Computer Science 2022-03-02 Bonifaz Stuhr , Jürgen Brauer

The presence of mislabeled observations in data is a notoriously challenging problem in statistics and machine learning, associated with poor generalization properties for both traditional classifiers and, perhaps even more so, flexible…

Machine Learning · Statistics 2022-02-09 Olof Zetterqvist , Rebecka Jörnsten , Johan Jonasson

This paper considers fixed effects (FE) estimation for linear panel data models under possible model misspecification when both the number of individuals, $n$, and the number of time periods, $T$, are large. We first clarify the probability…

Statistics Theory · Mathematics 2014-03-12 Antonio F. Galvao , Kengo Kato