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Lymph node metastasis (LNM) is a significant prognostic factor in patients with head and neck cancer, and the ability to predict it accurately is essential for treatment optimization. PET and CT imaging are routinely used for LNM…

Although the combined treatment of surgery, radiotherapy, chemotherapy, and emerging target therapy has significantly improved the outcomes of patients with head and neck cancer, distant metastasis remains the leading cause of treatment…

Quantitative Methods · Quantitative Biology 2025-12-02 Nuo Tong , Changhao Liu , Zizhao Tang , Feifan Sun , Yingping Li , Shuiping Gou , Mei Shi

Accurate prognosis for an individual patient is a key component of precision oncology. Recent advances in machine learning have enabled the development of models using a wider range of data, including imaging. Radiomics aims to extract…

Lymph node (LN) metastasis status is one of the most critical prognostic and cancer staging factors for patients with resectable pancreatic ductal adenocarcinoma (PDAC), or in general, for any types of solid malignant tumors. Preoperative…

Image and Video Processing · Electrical Eng. & Systems 2023-01-05 Zhilin Zheng , Xu Fang , Jiawen Yao , Mengmeng Zhu , Le Lu , Lingyun Huang , Jing Xiao , Yu Shi , Hong Lu , Jianping Lu , Ling Zhang , Chengwei Shao , Yun Bian

Automatic segmentation of head and neck cancer (HNC) tumors and lymph nodes plays a crucial role in the optimization treatment strategy and prognosis analysis. This study aims to employ nnU-Net for automatic segmentation and radiomics for…

Image and Video Processing · Electrical Eng. & Systems 2022-11-21 Hui Xu , Yihao Li , Wei Zhao , Gwenolé Quellec , Lijun Lu , Mathieu Hatt

Outcome prediction is crucial for head and neck cancer patients as it can provide prognostic information for early treatment planning. Radiomics methods have been widely used for outcome prediction from medical images. However, these…

Image and Video Processing · Electrical Eng. & Systems 2023-03-21 Mingyuan Meng , Lei Bi , Dagan Feng , Jinman Kim

Predicting outcomes, such as survival or metastasis for individual cancer patients is a crucial component of precision oncology. Machine learning (ML) offers a promising way to exploit rich multi-modal data, including clinical information…

Machine Learning · Computer Science 2021-06-04 Michal Kazmierski , Benjamin Haibe-Kains

We present a hybrid algorithm to estimate lung nodule malignancy that combines imaging biomarkers from Radiologist's annotation with image classification of CT scans. Our algorithm employs a 3D Convolutional Neural Network (CNN) as well as…

Image and Video Processing · Electrical Eng. & Systems 2020-10-23 Kushal Mehta , Arshita Jain , Jayalakshmi Mangalagiri , Sumeet Menon , Phuong Nguyen , David R. Chapman

Lymph node metastasis (LNM) is a crucial factor in determining the initial treatment for patients with lung cancer, yet accurate preoperative diagnosis of LNM remains challenging. Recently, large language models (LLMs) have garnered…

Computation and Language · Computer Science 2024-08-16 Danqing Hu , Bing Liu , Xiaofeng Zhu , Nan Wu

Despite the unprecedented performance of deep neural networks (DNNs) in computer vision, their practical application in the diagnosis and prognosis of cancer using medical imaging has been limited. One of the critical challenges for…

Machine Learning · Computer Science 2023-04-27 Lennart Brocki , Neo Christopher Chung

Metastasis on lymph nodes (LNs), the most common way of spread for primary tumor cells, is a sign of increased mortality. However, metastatic LNs are time-consuming and challenging to detect even for professional radiologists due to their…

Image and Video Processing · Electrical Eng. & Systems 2023-01-10 Chaoyi Wu , Feng Chang , Xiao Su , Zhihan Wu , Yanfeng Wang , Ling Zhu , Ya Zhang

A reliable locoregional recurrence (LRR) prediction model is important for the personalized management of head and neck cancers (HNC) patients. This work aims to develop a delta-radiomics feature-based multi-classifier, multi-objective, and…

Medical Physics · Physics 2023-05-10 Kai Wang , Michael Dohopolski , Qiongwen Zhang , David Sher , Jing Wang

Lymph node (LN) assessment is a critical, indispensable yet very challenging task in the routine clinical workflow of radiology and oncology. Accurate LN analysis is essential for cancer diagnosis, staging, and treatment planning. Finding…

Computer Vision and Pattern Recognition · Computer Science 2025-04-24 Yirui Wang , Qinji Yu , Ke Yan , Haoshen Li , Dazhou Guo , Li Zhang , Le Lu , Na Shen , Qifeng Wang , Xiaowei Ding , Xianghua Ye , Dakai Jin

Automatic lymph node (LN) segmentation and detection for cancer staging are critical. In clinical practice, computed tomography (CT) and positron emission tomography (PET) imaging detect abnormal LNs. Despite its low contrast and variety in…

Image and Video Processing · Electrical Eng. & Systems 2022-12-23 Al-Akhir Nayan , Boonserm Kijsirikul , Yuji Iwahori

Accurate survival prediction in head and neck cancer (HNC) is essential for guiding clinical decision-making and optimizing treatment strategies. Traditional models, such as Cox proportional hazards, have been widely used but are limited in…

Computer Vision and Pattern Recognition · Computer Science 2024-10-30 Aiman Farooq , Utkarsh Sharma , Deepak Mishra

Radiomics analysis has achieved great success in recent years. However, conventional Radiomics analysis suffers from insufficiently expressive hand-crafted features. Recently, emerging deep learning techniques, e.g., convolutional neural…

Image and Video Processing · Electrical Eng. & Systems 2019-10-22 Jiancheng Yang , Rongyao Fang , Bingbing Ni , Yamin Li , Yi Xu , Linguo Li

Accurate preoperative assessment of lymph node (LN) metastasis in rectal cancer guides treatment decisions, yet conventional MRI evaluation based on morphological criteria shows limited diagnostic performance. While some artificial…

Machine Learning · Computer Science 2025-07-16 Yaoxian Dong , Yifan Gao , Haoyue Li , Yanfen Cui , Xin Gao

While deep learning methods are increasingly being applied to tasks such as computer-aided diagnosis, these models are difficult to interpret, do not incorporate prior domain knowledge, and are often considered as a "black-box." The lack of…

Computer Vision and Pattern Recognition · Computer Science 2018-06-05 Shiwen Shen , Simon X. Han , Denise R. Aberle , Alex A. T. Bui , Willliam Hsu

Brain metastases affect approximately between 20% and 40% of cancer patients and are commonly treated with radiotherapy or radiosurgery. Early prediction of recurrence following treatment could enable timely clinical intervention and…

Image and Video Processing · Electrical Eng. & Systems 2025-12-18 Ines Faria , Matheus Silva , Crystian Saraiva , Jose Soares , Victor Alves

Computed tomography (CT) examinations are commonly used to predict lung nodule malignancy in patients, which are shown to improve noninvasive early diagnosis of lung cancer. It remains challenging for computational approaches to achieve…

Computer Vision and Pattern Recognition · Computer Science 2018-02-07 Jason Causey , Junyu Zhang , Shiqian Ma , Bo Jiang , Jake Qualls , David G. Politte , Fred Prior , Shuzhong Zhang , Xiuzhen Huang
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