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Neuronal cells present periodic trains of localized voltage spikes involving a large amount of different ionic channels. A relevant question is whether this is a cooperative effect or it could also be an intrinsic property of individual…

Biological Physics · Physics 2018-04-17 Laureano Ramírez-Piscina , José M. Sancho

Routing mechanisms for stochastic networks are often designed to produce state space collapse (SSC) in a heavy-traffic limit, i.e., to confine the limiting process to a lower-dimensional subset of its full state space. In a fluid limit, a…

Probability · Mathematics 2014-07-29 Ohad Perry , Ward Whitt

Fluctuation analysis is a method which allows measurement of the single channel current of ion channels even when it is too small to be resolved directly with the patch clamp technique. This is the case for voltage-gated Ca2+ channels…

Neurons and Cognition · Quantitative Biology 2017-12-13 Christian Scheppach , Hugh P. C. Robinson

In this paper, we propose and validate a two-species Multiscale model for a Poisson-Nernst-Planck (PNP) system, focusing on the correlated motion of positive and negative ions under the influence of a trap. Specifically, we aim to model…

Numerical Analysis · Mathematics 2026-04-28 Clarissa Astuto , Giovanni Russo

Particles in pressure-driven channel flow are often inhomogeneously distributed. Two modes of low-Reynolds number instability, absent in Poiseuille flow of clean fluid, are created by inhomogeneous particle loading, and their mechanism is…

Fluid Dynamics · Physics 2024-11-27 Anup Kumar , Rama Govindarajan

We present a two channel driven lattice gas model with oppositely directed species moving on two parallel lanes with lane switching processes. We study correlated lane switching mechanism for particles so that switching may occur with…

Statistical Mechanics · Physics 2015-05-28 Sudipto Muhuri , Ignacio Pagonabarraga

The single-particle density of states and the tunneling conductance are studied for a two-dimensional BCS-like Hamiltonian with a d_{x^2-y^2}-gap and phase fluctuations. The latter are treated by a classical Monte Carlo simulation of an XY…

Superconductivity · Physics 2009-11-07 T. Eckl , D. J. Scalapino , E. Arrigoni , W. Hanke

Ion traps are a versatile tool to study nonequilibrium statistical physics, due to the tunability of dissipation and nonlinearity. We propose an experiment with a chain of trapped ions, where dissipation is provided by laser heating and…

Pattern Formation and Solitons · Physics 2011-04-06 Tony E. Lee , M. C. Cross

Numerical methods are proposed for an advanced Poisson-Nernst-Planck-Fermi (PNPF) model for studying ion transport through biological ion channels. PNPF contains many more correlations than most models and simulations of channels, because…

Biomolecules · Quantitative Biology 2015-06-22 Jinn-Liang Liu , Bob Eisenberg

The dynamics and the steady states of a point-like tracer particle immersed in a confined critical fluid are studied. The fluid is modeled field-theoretically in terms of an order parameter (concentration or density field) obeying…

Statistical Mechanics · Physics 2023-01-03 Markus Gross

A continuously measured quantum system with multiple jump channels gives rise to a stochastic process described by random jump times and random emitted symbols, representing each jump channel. While much is known about the waiting time…

Quantum Physics · Physics 2023-06-21 Gabriel T. Landi

Canalization is a classic concept in Developmental Biology that is thought to be an important feature of evolving systems. In a Boolean network it is a form of network robustness in which a subset of the input signals control the behavior…

Molecular Networks · Quantitative Biology 2015-05-28 Matthew D. Reichl , Kevin E. Bassler

We propose a simple discrete stochastic model for calcium dynamics in living cells. Specifically, the calcium concentration distribution is assumed to give rise to a set of probabilities for the opening/closing of channels which release…

patt-sol · Physics 2009-10-31 Markus Baer , Martin Falcke , Herbert Levine , Lev S. Tsimring

It is shown that bifurcations of the mean-field dynamics of a Bose-Einstein condensate can be related with the quantum phase transitions of the original many-body system. As an example we explore the intra-band tunneling in the…

Other Condensed Matter · Physics 2009-11-13 V. S. Shchesnovich , V. V. Konotop

Gene expression has a stochastic component owing to the single molecule nature of the gene and the small number of copies of individual DNA binding proteins in the cell. We show how the statistics of such systems can be mapped on to quantum…

Disordered Systems and Neural Networks · Physics 2009-11-10 Masaki Sasai , Peter G. Wolynes

Measured responses from visual cortical neurons show that spike times tend to be correlated rather than exactly Poisson distributed. Fano factors vary and are usually greater than 1 due to the tendency of spikes being clustered into bursts.…

Neurons and Cognition · Quantitative Biology 2007-05-23 Alexander Lerchner , Mandana Ahmadi , John Hertz

Gating mechanisms are widely used in neural network models, where they allow gradients to backpropagate more easily through depth or time. However, their saturation property introduces problems of its own. For example, in recurrent models…

Neural and Evolutionary Computing · Computer Science 2020-06-22 Albert Gu , Caglar Gulcehre , Tom Le Paine , Matt Hoffman , Razvan Pascanu

Key features of biological activity can often be captured by transitions between a finite number of semi-stable states that correspond to behaviors or decisions. We present here a broad class of dynamical systems that are ideal for modeling…

Dynamical Systems · Mathematics 2022-12-14 Megan Morrison , Lai-Sang Young

We consider the overdamped dynamics of a paradigmatic long-range system of particles residing on the sites of a one-dimensional lattice, in the presence of thermal noise. The internal degree of freedom of each particle is a periodic…

Statistical Mechanics · Physics 2013-12-03 Shamik Gupta , Alessandro Campa , Stefano Ruffo

We report and characterize the emergence of a noise-induced state of quenched disorder in a generic model describing a dense sheet of active polar disks with non-isotropic rotational and translational dynamics. In this state, randomly…

Soft Condensed Matter · Physics 2023-04-10 Guozheng Lin , Zhangang Han , Amir Shee , Cristián Huepe