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A tumor can be thought of as an ecosystem, which critically means that we cannot just consider it as a collection of mutated cells but more as a complex system of many interacting cellular and microenvironmental elements. At its simplest, a…

Populations and Evolution · Quantitative Biology 2013-05-03 Jill Gallaher , Alexander R. A. Anderson

A common assumption in evolutionary thought is that adaptation drives an increase in biological complexity. However, the rules governing evolution of complexity appear more nuanced. Evolution is deeply connected to learning, where…

Populations and Evolution · Quantitative Biology 2025-08-06 Hagai Rappeport , Mor Nitzan

The interaction between natural selection and random mutation is frequently debated in recent years. Does similar dilemma also exist in the evolution of real networks such as biological networks? In this paper, we try to discuss this issue…

Statistical Mechanics · Physics 2009-01-07 Zhen Shao , Hai-jun Zhou

We model evolution of plants in a world, made up of different locations, with multiple environments (mutually exclusive and collectively exhaustive subsets of locations). Each environment (landmass) has temperature, rainfall, and other…

Populations and Evolution · Quantitative Biology 2019-05-27 Alexander , Khazatsky , Albert Yu , Zihao Zhao , Gabe Zuckerman

An extension of coupled maps is given which allows for the growth of the number of elements, and is inspired by the cell differentiation problem. The growth of elements is made possible first by clustering the phases, and then by…

adap-org · Physics 2009-10-28 Kunihiko Kaneko

When a biological system robustly corrects component-level errors, the direct pressure on component performance declines. Components may become less reliable, maintain more genetic variability, or drift neutrally in design, creating the…

Populations and Evolution · Quantitative Biology 2023-12-27 Steven A. Frank

A central and long-standing issue in evolutionary theory is the origin of the biological variation upon which natural selection acts1. Some hypotheses suggest that evolutionary change represents an adaptation to the surrounding environment…

Statistical Mechanics · Physics 2007-05-23 J. Podani , Z. N. Oltvai , H. Jeong , B. Tombor , A. -L. Barabasi , E. Szathmary

Understanding how growth induces form is a longstanding biological question. Many studies concentrated on the shapes of plant cells, fungi or bacteria. Some others have shown the importance of the mechanical properties of bacterial walls…

Biological Physics · Physics 2007-05-23 Arezki Boudaoud

In order to make a case for or against a trend in the evolution of complexity in biological evolution, complexity needs to be both rigorously defined and measurable. A recent information-theoretic (but intuitively evident) definition…

Biological Physics · Physics 2016-09-08 Christoph Adami , Charles Ofria , Travis C. Collier

The evolution of cooperation often depends upon population structure, yet nearly all models of cooperation implicitly assume that this structure remains static. This is a simplifying assumption, because most organisms possess genetic traits…

Populations and Evolution · Quantitative Biology 2012-08-03 Simon T. Powers , Alexandra S. Penn , Richard A. Watson

The co-evolution of structure and dynamics, known as adaptivity, is a fundamental property in various systems and drives diverse emergent behaviors. However, the adaptivity in previous works is primarily stemmed from pairwise situations,…

Physics and Society · Physics 2025-08-22 Longzhao Liu , Hongwei Zheng , Zhihao Han , Xin Wang , Shaoting Tang

The growth of science and technology is a recombinative process, wherein new discoveries and inventions are built from prior knowledge. Yet relatively little is known about the manner in which scientific and technological knowledge develop…

Social and Information Networks · Computer Science 2020-11-25 Thomas Gebhart , Russell J. Funk

Different evolutionary models are known to make disparate predictions for the success of an invading mutant in some situations. For example, some evolutionary mechanics lead to amplification of selection in structured populations, while…

Populations and Evolution · Quantitative Biology 2020-07-01 Francisco Herrerías-Azcué , Vicente Pérez-Muñuzuri , Tobias Galla

A major aim of evolutionary biology is to explain the respective roles of adaptive versus non-adaptive changes in the evolution of complexity. While selection is certainly responsible for the spread and maintenance of complex phenotypes,…

Populations and Evolution · Quantitative Biology 2017-01-17 Thomas LaBar , Christoph Adami

The nature and source of evolutionary trends in complexity is difficult to assess from the fossil record, and the driven vs. passive nature of such trends has been debated for decades. There are also questions about how effectively…

Neural and Evolutionary Computing · Computer Science 2011-12-22 Larry Yaeger , Virgil Griffith , Olaf Sporns

Development combines three basic processes asymmetric --- cell division, signaling and gene regulation --- in a multitude of ways to create an overwhelming diversity of multicellular life-forms. Here, we attempt to chart this diversity…

Molecular Networks · Quantitative Biology 2020-01-01 Somya Mani , Tsvi Tlusty

We often associate compound growth with the Anthropocene and our overwhelming economic impacts on the Earth. Today our actual choices for future society appear to lie with studying the class of emergent natural systems that first develop by…

Physics and Society · Physics 2022-02-08 Jessie Henshaw

We introduce a new model for large scale evolution and extinction in which species are organized into food chains. The system evolves by two processes: origination/speciation and extinction. In the model, extinction of a given species can…

Statistical Mechanics · Physics 2007-05-23 Luis A. N. Amaral , Martin Meyer

Cellular biology exists embedded in a world dominated by random dynamics and chance. Many vital molecules and pieces of cellular machinery diffuse within cells, moving along random trajectories as they collide with the other biomolecular…

Cell Behavior · Quantitative Biology 2012-08-13 Iain G. Johnston