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We study the effect of intrinsic noise on the thermodynamic balance of complex chemical networks subtending cellular metabolism and gene regulation. A topological network property called deficiency, known to determine the possibility of…

Molecular Networks · Quantitative Biology 2015-11-12 Matteo Polettini , Artur Wachtel , Massimiliano Esposito

Climate change is reshaping species interactions and movement across fragmented landscapes. Despite this, most mathematical models assume random diffusion, overlooking the influence of directed movement. Here, we develop a graph based…

Dynamical Systems · Mathematics 2026-04-08 Pranali Roy Chowdhury , Soumyendu Raha

Traditional chemical kinetics may be inappropriate to describe chemical reactions in micro-domains involving only a small number of substrate and reactant molecules. Starting with the stochastic dynamics of the molecules, we derive a…

Mathematical Physics · Physics 2009-11-10 D. Holcman , Z. Schuss

Many approaches to modelling reaction-diffusion systems with anomalous transport rely on deterministic equations and ignore fluctuations arising due to finite particle numbers. Starting from an individual-based model we use a…

Statistical Mechanics · Physics 2019-05-29 Joseph W. Baron , Tobias Galla

In an experimental study of single enzyme reactions, it has been proposed that the rate constants of the enzymatic reactions fluctuate randomly, according to a given distribution. To quantify the uncertainty arising from random rate…

Quantitative Methods · Quantitative Biology 2012-02-07 Chia Ying Lee

We propose an adaptive diffusion mechanism to optimize a global cost function in a distributed manner over a network of nodes. The cost function is assumed to consist of a collection of individual components. Diffusion adaptation allows the…

Optimization and Control · Mathematics 2015-06-03 Jianshu Chen , Ali H. Sayed

Using an example of physical interactions between proteins, we study how perturbations propagate in interconnected networks whose equilibrium state is governed by the law of mass action. We introduce a comprehensive matrix formalism which…

Molecular Networks · Quantitative Biology 2009-11-13 Sergei Maslov , Kim Sneppen , Iaroslav Ispolatov

We develop a general classification of the nature of the instabilities yielding spatial organization in open nonideal reaction-diffusion systems, based on linear stability analysis. This encompasses dynamics where chemical species diffuse,…

Statistical Mechanics · Physics 2023-10-05 Timur Aslyamov , Francesco Avanzini , Étienne Fodor , Massimiliano Esposito

This paper is concerned with classes of models of stochastic reaction dynamics with time-scales separation. We demonstrate that the existence of the time-scale separation naturally leads to the application of the averaging principle and…

Computational Physics · Physics 2007-05-23 Sergey Plyasunov

Biochemical reactions can happen on different time scales and also the abundance of species in these reactions can be very different from each other. Classical approaches, such as deterministic or stochastic approach, fail to account for or…

Quantitative Methods · Quantitative Biology 2014-09-16 Arnab Ganguly , Derya Altintan , Heinz Koeppl

In this paper, we study resilient distributed diffusion for multi-task estimation in the presence of adversaries where networked agents must estimate distinct but correlated states of interest by processing streaming data. We show that in…

Multiagent Systems · Computer Science 2020-03-25 Jiani Li , Waseem Abbas , Xenofon Koutsoukos

Deep Generative Models (DGMs), including Energy-Based Models (EBMs) and Score-based Generative Models (SGMs), have advanced high-fidelity data generation and complex continuous distribution approximation. However, their application in…

Machine Learning · Computer Science 2024-10-03 Yangming Li , Chieh-Hsin Lai , Carola-Bibiane Schönlieb , Yuki Mitsufuji , Stefano Ermon

Understanding the relationship between spontaneous stochastic fluctuations and the topology of the underlying gene regulatory network is of fundamental importance for the study of single-cell stochastic gene expression. Here by solving the…

Molecular Networks · Quantitative Biology 2017-10-25 Chen Jia , Peng Xie , Min Chen , Michael Q. Zhang

We consider a broad class of stochastic imitation dynamics over networks, encompassing several well known learning models such as the replicator dynamics. In the considered models, players have no global information about the game…

Systems and Control · Computer Science 2021-03-02 Lorenzo Zino , Giacomo Como , Fabio Fagnani

Resetting or restart, when applied to a stochastic process, usually brings its dynamics to a time-independent stationary state. In turn, the optimal resetting rate makes the mean time to reach a target to be the shortest one. These and…

Statistical Mechanics · Physics 2022-08-31 Przemyslaw Chelminiak

Diffusion is the macroscopic manifestation of disordered molecular motion. Mathematically, diffusion equations are partial differential equations describing the fluid-like large-scale dynamics of parcels of molecules. Spatially…

Fluid Dynamics · Physics 2018-10-26 F. Sattin , A. Bonato , L. Salasnich

To better understand the temporal characteristics and the lifetime of fluctuations in stochastic processes in networks, we investigated diffusive persistence in various graphs. Global diffusive persistence is defined as the fraction of…

Statistical Mechanics · Physics 2024-06-04 Omar Malik , Melinda Varga , Alaa Moussawi , David Hunt , Boleslaw Szymanski , Zoltan Toroczkai , Gyorgy Korniss

We investigate dynamics near Turing patterns in reaction-diffusion systems posed on the real line. Linear analysis predicts diffusive decay of small perturbations. We construct a "normal form" coordinate system near such Turing patterns…

Analysis of PDEs · Mathematics 2015-10-29 Arnd Scheel , Qiliang Wu

We prove the emergence of stable fluctuations for reaction-diffusion in random environment with Weibull tails. This completes our work around the quenched to annealed transition phenomenon in this context of reaction diffusion. In [9], we…

Probability · Mathematics 2017-06-22 Gérard Ben Arous , Stanislav Molchanov , Alejandro F. Ramírez

Fluctuating hydrodynamics (FHD) provides a framework for modeling microscopic fluctuations in a manner consistent with statistical mechanics and nonequilibrium thermodynamics. This paper presents an FHD formulation for isothermal reactive…

Fluid Dynamics · Physics 2018-09-05 Changho Kim , Andy Nonaka , John B. Bell , Alejandro L. Garcia , Aleksandar Donev
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