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Genome-wide association studies (GWAS) have identified hundreds of loci at very stringent levels of statistical significance across many different human traits. However, it is now clear that very large samples (n~10^4-10^5) are needed to…

Genomics · Quantitative Biology 2013-08-20 Inti Pedroso

Generative Adversarial Networks (GANs) and their extensions have carved open many exciting ways to tackle well known and challenging medical image analysis problems such as medical image de-noising, reconstruction, segmentation, data…

Computer Vision and Pattern Recognition · Computer Science 2019-10-10 Salome Kazeminia , Christoph Baur , Arjan Kuijper , Bram van Ginneken , Nassir Navab , Shadi Albarqouni , Anirban Mukhopadhyay

The rapid growth of publicly available textual resources, such as lexicons and domain-specific corpora, presents challenges in efficiently identifying relevant resources. While repositories are emerging, they often lack advanced search and…

Databases · Computer Science 2025-08-01 Anaïs Ollagnier , Aline Menin

Genome-Wide Association Studies (GWAS) identify associations between genetic variants and disease; however, moving beyond associations to causal mechanisms is critical for therapeutic target prioritization. The recently proposed Knowledge…

Information visualization and visual analytics technology has attracted significant attention from the financial regulation community. In this research, we present regvis.net, a visual survey of regulatory visualization that allows…

Computers and Society · Computer Science 2020-07-08 Zhibin Niu , Runlin Li , Junqi Wu , Yaqi Xue , Jiawan Zhang

Over the years, genetic programming (GP) has evolved, with many proposed variations, especially in how they represent a solution. Being essentially a program synthesis algorithm, it is capable of tackling multiple problem domains. Current…

Neural and Evolutionary Computing · Computer Science 2025-04-15 Roman Kalkreuth , Fabricio Olivetti de França , Julian Dierkes , Marie Anastacio , Anja Jankovic , Zdenek Vasicek , Holger Hoos

Identifying genes associated with complex human diseases is one of the main challenges of human genetics and computational medicine. To answer this question, millions of genetic variants get screened to identify a few of importance. To…

Genomics · Quantitative Biology 2015-09-01 Aziz M. Mezlini , Fabio Fuligni , Adam Shlien , Anna Goldenberg

This paper demonstrates how to use generative models trained for image synthesis as tools for visual data mining. Our insight is that since contemporary generative models learn an accurate representation of their training data, we can use…

Computer Vision and Pattern Recognition · Computer Science 2024-08-07 Ioannis Siglidis , Aleksander Holynski , Alexei A. Efros , Mathieu Aubry , Shiry Ginosar

Interactive visualization tools are highly desirable to biologist and cancer researchers to explore the complex structures, detect patterns and find out the relationships among bio-molecules responsible for a cancer type. A pathway contains…

Quantitative Methods · Quantitative Biology 2017-10-23 Vinh Nguyen , Md Yasin Kabir , Tommy Dang

High-throughput technologies to collect field data have made observations possible at scale in several branches of life sciences. The data collected can range from the molecular level (genotypes) to physiological (phenotypic traits) and…

Computational Geometry · Computer Science 2021-07-07 Youjia Zhou , Methun Kamruzzaman , Patrick Schnable , Bala Krishnamoorthy , Ananth Kalyanaraman , Bei Wang

Several graph visualization tools exist. However, they are not able to handle large graphs, and/or they do not allow interaction. We are interested on large graphs, with hundreds of thousands of nodes. Such graphs bring two challenges: the…

Social and Information Networks · Computer Science 2015-06-15 Jose Rodrigues , Hanghang Tong , Agma Traina , Christos Faloutsos , Jure Leskovec

Fencing is a sport that relies heavily on the use of tactics. However, most existing methods for analyzing fencing data are based on statistical models in which hidden patterns are difficult to discover. Unlike sequential games, such as…

Human-Computer Interaction · Computer Science 2020-11-04 Mingdong Zhang , Li Chen , Xiaoru Yuan , Renpei Huang , Shuang Liu , Junhai Yong

Exploring tabular datasets to understand how different feature pairs partition data into meaningful cohorts is crucial in domains such as biomarker discovery, yet comparing clusters across multiple feature pair projections is challenging.…

Human-Computer Interaction · Computer Science 2026-01-21 Lukas Schilcher , Peter Waldert , Benedikt Kantz , Tobias Schreck

Modern data collection in many data paradigms, including bioinformatics, often incorporates multiple traits derived from different data types (i.e. platforms). We call this data multi-block, multi-view, or multi-omics data. The emergent…

Methodology · Statistics 2024-01-18 Jack B. Prothero , Meilei Jiang , Jan Hannig , Quoc Tran-Dinh , Andrew Ackerman , J. S. Marron

Given a large social or computer network, how can we visualize it, find patterns, outliers, communities? Although several graph visualization tools exist, they cannot handle large graphs with hundred thousand nodes and possibly million…

Social and Information Networks · Computer Science 2015-07-07 Jose Rodrigues , Agma Traina , Christos Faloutsos , Caetano Traina

Statistical methods for genomewide association studies (GWAS) continue to improve. However, the increasing volume and variety of genetic and genomic data make computational speed and ease of data manipulation mandatory in future software.…

Motivation: The rapid growth of diverse biological data allows us to consider interactions between a variety of objects, such as genes, chemicals, molecular signatures, diseases, pathways and environmental exposures. Often, any pair of…

Machine Learning · Computer Science 2017-08-14 Marinka Zitnik , Blaz Zupan

We study the challenges of applying deep learning to gene expression data. We find experimentally that there exists non-linear signal in the data, however is it not discovered automatically given the noise and low numbers of samples used in…

Genomics · Quantitative Biology 2018-06-20 Francis Dutil , Joseph Paul Cohen , Martin Weiss , Georgy Derevyanko , Yoshua Bengio

Computer graphics, often associated with films, games, and visual effects, has long been a powerful tool for addressing scientific challenges--from its origins in 3D visualization for medical imaging to its role in modern computational…

Background: The eMouse Atlas of Gene Expression (EMAGE) is an online resource that publishes the results of in situ gene expression experiments on the developmental mouse. The resource provides comprehensive search facilities, but few…

Human-Computer Interaction · Computer Science 2014-07-09 Andy Taylor , Kenneth McLeod , Chris Armit , Richard Baldock , Albert Burger