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Background: Parkinson's disease (PD) is a prevalent long-term neurodegenerative disease. Though the diagnostic criteria of PD are relatively well defined, the current medical imaging diagnostic procedures are expertise-demanding, and thus…

Quantitative Methods · Quantitative Biology 2019-02-27 Jiahang Xu , Fangyang Jiao , Yechong Huang , Xinzhe Luo , Qian Xu , Ling Li , Xueling Liu , Chuantao Zuo , Ping Wu , Xiahai Zhuang

Background and objectives: Parkinson's disease is a neurological disorder that affects the motor system producing lack of coordination, resting tremor, and rigidity. Impairments in handwriting are among the main symptoms of the disease.…

Machine Learning · Computer Science 2020-02-14 C. D. Rios-Urrego , J. C. Vásquez-Correa , J. F. Vargas-Bonilla , E. Nöth , F. Lopera , J. R. Orozco-Arroyave

Evaluating neurological disorders such as Parkinson's disease (PD) is a challenging task that requires the assessment of several motor and non-motor functions. In this paper, we present an end-to-end deep learning framework to measure PD…

Computer Vision and Pattern Recognition · Computer Science 2020-12-25 Amirhossein Dadashzadeh , Alan Whone , Michal Rolinski , Majid Mirmehdi

In recent years, sensors from smart consumer devices have shown great diagnostic potential in movement disorders. In this context, data modalities such as electronic questionnaires, hand movement and voice captures have successfully…

Machine Learning · Computer Science 2022-05-13 Catharina Marie van Alen , Alexander Brenner , Tobias Warnecke , Julian Varghese

In this work we propose a new biophysical computational model of brain regions relevant to Parkinson's Disease based on local field potential data collected from the brain of marmoset monkeys. Parkinson's disease is a neurodegenerative…

Limited accessibility to neurological care leads to underdiagnosed Parkinson's Disease (PD), preventing early intervention. Existing AI-based PD detection methods primarily focus on unimodal analysis of motor or speech tasks, overlooking…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Md Saiful Islam , Tariq Adnan , Jan Freyberg , Sangwu Lee , Abdelrahman Abdelkader , Meghan Pawlik , Cathe Schwartz , Karen Jaffe , Ruth B. Schneider , E Ray Dorsey , Ehsan Hoque

Early-stage Parkinson's disease (EarlyPD) detection from speech is clinically meaningful yet underexplored, and published results are hard to compare because studies differ in datasets, languages, tasks, evaluation protocols, and EarlyPD…

Audio and Speech Processing · Electrical Eng. & Systems 2026-05-15 Terry Yi Zhong , Cristian Tejedor-Garcia , Khiet P. Truong , Janna Maas , Louis ten Bosch , Bastiaan R. Bloem

Parkinson's disease (PD) is projected to increase substantially due to population aging, making early diagnosis increasingly important, as timely detection may delay progression and reduce long-term complications. Retinal microvasculature…

One of the most prevalent complaints of individuals with mid-stage and advanced Parkinson's disease (PD) is the fluctuating response to their medication (i.e., ON state with maximum benefit from medication and OFF state with no benefit from…

Computer Vision and Pattern Recognition · Computer Science 2018-09-20 Murtadha D. Hssayeni , Michelle A. Burack , M. D. , Joohi Jimenez-Shahed , M. D. , Behnaz Ghoraani , Ph. D

Parkinson's Disease (PD) significantly impacts driving abilities, often leading to early driving cessation or accidents due to reduced motor control and increasing reaction times. To diminish the impact of these symptoms, we developed PANDA…

Human-Computer Interaction · Computer Science 2025-03-11 Tianyang Wen , Xucheng Zhang , Zhirong Wan , Jing Zhao , Yicheng Zhu , Ning Su , Xiaolan Peng , Jin Huang , Wei Sun , Feng Tian , Franklin Mingzhe Li

Parkinson's disease (PD) is a neurodegenerative disorder, manifesting with motor and non-motor symptoms. Depressive symptoms are prevalent in PD, affecting up to 45% of patients. They are often underdiagnosed due to overlapping motor…

Early and accurate detection of Parkinson's disease (PD) remains a critical challenge in medical diagnostics due to the subtlety of early-stage symptoms and the complex, non-linear relationships inherent in biomedical data. Traditional…

Machine Learning · Computer Science 2026-02-10 Olamide Samuel Oseni , Ibraheem Omotolani Obanla , Toheeb Aduramomi Jimoh

Parkinson's disease (PD) presents a growing global challenge, affecting over 10 million individuals, with prevalence expected to double by 2040. Early diagnosis remains difficult due to the late emergence of motor symptoms and limitations…

Machine Learning · Computer Science 2025-10-21 Arianna Francesconi , Donato Cappetta , Fabio Rebecchi , Paolo Soda , Valerio Guarrasi , Rosa Sicilia

Parkinson's disease (PD) is commonly characterized by several motor symptoms, such as bradykinesia, akinesia, rigidity, and tremor. The analysis of patients' fine motor control, particularly handwriting, is a powerful tool to support PD…

Computer Vision and Pattern Recognition · Computer Science 2021-01-26 Moises Diaz , Momina Moetesum , Imran Siddiqi , Gennaro Vessio

Parkinson's Disease (PD) is a progressive neurodegenerative movement disorder that affects more that 6 million people worldwide. Motor dysfunction gradually increases as the disease progress. It is usually mild in the early stages of the…

Computers and Society · Computer Science 2015-11-12 Ioannis Pachoulakis , Nikolaos Papadopoulos , Cleanthe Spanaki

Parkinson's Disease (PD) is one of the most prevalent neurodegenerative diseases that affects tens of millions of Americans. PD is highly progressive and heterogeneous. Quite a few studies have been conducted in recent years on predictive…

Computer Vision and Pattern Recognition · Computer Science 2019-05-08 Xi Sheryl Zhang , Lifang He , Kun Chen , Yuan Luo , Jiayu Zhou , Fei Wang

Orofacial deficits are common in people with Parkinson's disease (PD) and their evolution might represent an important biomarker of disease progression. We are developing an automated system for assessment of orofacial function in PD that…

Computer Vision and Pattern Recognition · Computer Science 2020-03-19 Diego L. Guarin , Aidan Dempster , Andrea Bandini , Yana Yunusova , Babak Taati

Parkinson's Disease (PD) is a neurodegenerative disorder that significantly impacts motor and non-motor functions. There is currently no treatment that slows or stops neurodegeneration in PD. In this context, assistive technologies (ATs)…

Human-Computer Interaction · Computer Science 2025-05-27 Subek Acharya , Sansrit Paudel

One of the symptoms observed in the early stages of Parkinson's Disease (PD) is speech impairment. Speech disorders can be used to detect this disease before it degenerates. This work analyzes speech features and machine learning approaches…

Audio and Speech Processing · Electrical Eng. & Systems 2021-11-22 Adedolapo Aishat Toye , Suryaprakash Kompalli

Parkinson's disease (PD), a neurodegenerative disorder, often manifests as speech and voice dysfunction. While utilizing voice data for PD detection has great potential in clinical applications, the widely used deep learning models…

Machine Learning · Computer Science 2023-09-26 Yicheng Wang , Xiaotian Han , Leisheng Yu , Na Zou
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