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Living organisms rely on molecular networks, such as gene circuits and signaling pathways, for information processing and robust decision-making in crowded, noisy environments. Recent advances show that interacting biomolecules…

Within living cells, the transport of cargo is accomplished by groups of molecular motors. Such collective transport could utilize mechanisms which emerge from inter-motor interactions in ways that are yet to be fully understood. Here we…

Biomolecules · Quantitative Biology 2016-10-04 David Ando , Michelle K. Mattson , Jing Xu , Ajay Gopinathan

The dynamics of colloidal suspension confined within porous materials strongly differs from that in the bulk. In particular, within porous materials, the presence of boundaries with complex shapes entangles the longitudinal and transverse…

Soft Condensed Matter · Physics 2021-11-16 P. Malgaretti , A. M. Puertas , I. Pagonabarraga

Cells move differently on substrates with different elasticities. In particular, the persistence time of their motion is higher on stiffer substrates. We show that this behavior will result in a net transport of cells directed up a…

Biological Physics · Physics 2017-03-09 Elizaveta A. Novikova , Matthew Raab , Dennis E. Discher , Cornelis Storm

We extend the continuum theory of active nematic fluids to study cell flows and tissue dynamics inside multicellular spheroids, spherical, self-assembled aggregates of cells that are widely used as model systems to study tumour dynamics.…

Soft Condensed Matter · Physics 2022-08-18 Liam J Ruske , Julia M Yeomans

A wide range of experimental systems including gliding, swarming and swimming bacteria, in-vitro motility assays as well as shaken granular media are commonly described as self-propelled rods. Large ensembles of those entities display a…

Statistical Mechanics · Physics 2021-01-18 Markus Bär , Robert Großmann , Sebastian Heidenreich , Fernando Peruani

A generic flow distribution network typically does not deliver its load at a uniform rate across a service area, instead oversupplying regions near the nutrient source while leaving downstream regions undersupplied. In this work we…

Biological Physics · Physics 2021-09-06 Tatyana Gavrilchenko , Eleni Katifori

Intracellular cargo transport can arise from passive diffusion, active motor-driven transport along cytoskeletal filament networks, and passive advection by fluid flows entrained by such motor/cargo motion. Active and advective transport…

Biological Physics · Physics 2012-07-24 P. Khuc Trong , J. Guck , R. E. Goldstein

Living systems are capable of locomotion, reconfiguration, and replication. To perform these tasks, cells spatiotemporally coordinate the interactions of force-generating, "active" molecules that create and manipulate non-equilibrium…

Soft Condensed Matter · Physics 2019-08-28 Tyler D. Ross , Heun Jin Lee , Zijie Qu , Rachel A. Banks , Rob Phillips , Matt Thomson

Compartmentalization into biochemically distinct organelles constantly exchanging material is one of the hallmarks of eukaryotic cells. In the most naive picture of inter-organelle transport driven by concentration gradients, concentration…

Subcellular Processes · Quantitative Biology 2015-05-27 Serge Dmitrieff , Pierre Sens

Escherichia coli has long been used as a model organism due to the extensive experimental characterization of its pathways and molecular components. Take chemotaxis as an example, which allows bacteria to sense and swim in response to…

Cell Behavior · Quantitative Biology 2015-12-09 Gabriele Micali , Robert G. Endres

Fiberboids are active filaments trapped at the interface of two phases, able of harnessing energy (and matter) fluxes across the interface in order to produce a rolling-like self-propulsion. We discuss several table-top examples and develop…

Soft Condensed Matter · Physics 2020-05-19 Antony Bazir , Arthur Baumann , Falko Ziebert , Igor M. Kulic

The ability to dictate colloid motion is an important challenge in fields ranging from materials science to living systems. Here, by embedding energy landscapes in confined nematic liquid crystals, we design a versatile platform to define…

Soft Condensed Matter · Physics 2018-11-07 Yimin Luo , Daniel A. Beller , Giuseppe Boniello , Francesca Serra , Kathleen J. Stebe

Essentially all biology is active and dynamic. Biological entities autonomously sense, com- pute, and respond using energy-coupled ratchets that can produce force and do work. The cytoskeleton, along with its associated proteins and motors,…

Soft Condensed Matter · Physics 2017-03-28 Kasimira T. Stanhope , Vikrant Yadav , Christian D. Santangelo , Jennifer L. Ross

Liquid diodes are surface structures that facilitate the flow of liquids in a specific direction. When these structures are within the capillary regime, they promote liquid transport without the need for external forces. In nature, they are…

Soft Condensed Matter · Physics 2023-08-24 Camilla Sammartino , Yair Shokef , Bat-El Pinchasik

Recent studies aimed at investigating artificial analogs of bacterial colonies have shown that low-density suspensions of self-propelled particles confined in two dimensions can assemble into finite aggregates that merge and split, but have…

Soft Condensed Matter · Physics 2015-06-17 B. M. Mognetti , A. Šarić , S. Angioletti-Uberti , A. Cacciuto , C. Valeriani , D. Frenkel

Self-propelled colloidal objects, such as motile bacteria or synthetic microswimmers, have microscopically irreversible individual dynamics - a feature they share with all living systems. The incoherent behaviour of individual swimmers can…

Soft Condensed Matter · Physics 2016-04-06 J. Stenhammar , R. Wittkowski , D. Marenduzzo , M. E. Cates

Self-generated gradients have atttracted a lot of attention in the recent biological literature. It is considered as a robust strategy for a group of cells to find its way during a long journey. This note is intended to discuss various…

Analysis of PDEs · Mathematics 2021-09-15 Mete Demircigil , Vincent Calvez , Roxana Sublet

Single kinesin molecular motors can processively move along a microtubule (MT) a few micrometers on average before dissociating. However, cellular length scales over which transport occurs are several hundred microns and more. Why seemingly…

Subcellular Processes · Quantitative Biology 2019-08-21 Keshav B. Patel , Shengtan Mao , M. Gregory Forest , Samuel K. Lai , Jay M. Newby

We study the assembly of colloids in a two phase water-water system that provides an environment that can sustain bacteria, providing a new structure with rich potential to confine and structure living colloids. The water-water system,…

Soft Condensed Matter · Physics 2014-12-12 Sarah D. Hann , Mark Goulian , Daeyeon Lee , Kathleen J. Stebe
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