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We introduce TempoCave, a novel visualization application for analyzing dynamic brain networks, or connectomes. TempoCave provides a range of functionality to explore metrics related to the activity patterns and modular affiliations of…

Human-Computer Interaction · Computer Science 2020-01-16 Ran Xu , Manu Mathew Thomas , Alex Leow , Olusola Ajilore , Angus G. Forbes

Data produced by resting-state functional Magnetic Resonance Imaging are widely used to infer brain functional connectivity networks. Such networks correlate neural signals to connect brain regions, which consist in groups of dependent…

Methodology · Statistics 2023-12-05 Hanâ Lbath , Alexander Petersen , Sophie Achard

Higher brain function relies upon the ability to flexibly integrate information across specialized communities of brain regions, however it is unclear how this mechanism manifests over time. In this study, we use time-resolved network…

Functional connectivity varies across individuals due to genetic and environmental factors, yet classical twin models typically confound non-shared environment with measurement error and are largely limited to resting-state analyses. We…

The study of functional brain connectivity (FC) is important for understanding the underlying mechanisms of many psychiatric disorders. Many recent analyses adopt graph convolutional networks, to study non-linear interactions between…

Neurons and Cognition · Quantitative Biology 2021-09-08 Simon Dahan , Logan Z. J. Williams , Daniel Rueckert , Emma C. Robinson

Scientists construct connectomes, comprehensive descriptions of neuronal connections across a brain, in order to better understand and model brain function. Interactive visualizations of these pathways would enable exploratory analysis of…

Neurons and Cognition · Quantitative Biology 2022-05-06 Seth Daetwiler , Angus Read , Jessica Stillwell , Kameron Decker Harris

The joint analysis of multimodal neuroimaging data is critical in the field of brain research because it reveals complex interactive relationships between neurobiological structures and functions. In this study, we focus on investigating…

Methodology · Statistics 2025-03-25 Tong Lu , Yuan Zhang , Vince Lyzinski , Chuan Bi , Peter Kochunov , Elliot Hong , Shuo Chen

One of the crucial questions in neuroscience is how a rich functional repertoire of brain states relates to its underlying structural organization. How to study the associations between these structural and functional layers is an open…

Neurons and Cognition · Quantitative Biology 2018-02-22 Enrico Amico , Joaquín Goñi

The human brain is a complex network comprised of functionally and anatomically interconnected brain regions. A growing number of studies have suggested that empirical estimates of brain networks may be useful for discovery of biomarkers of…

Neurons and Cognition · Quantitative Biology 2022-11-15 Andrew Hannum , Mario A. Lopez , Saúl A. Blanco , Richard F. Betzel

There has been huge interest in studying human brain connectomes inferred from different imaging modalities and exploring their relationship with human traits, such as cognition. Brain connectomes are usually represented as networks, with…

Machine Learning · Statistics 2021-09-14 Meimei Liu , Zhengwu Zhang , David B. Dunson

We present a statistical framework that jointly models brain shape and functional connectivity, which are two complex aspects of the brain that have been classically studied independently. We adopt a Riemannian modeling approach to account…

Methodology · Statistics 2024-04-26 Eardi Lila , John A. D. Aston

Structural and functional neuroimaging modalities provide complementary windows into brain organization: structural imaging characterizes neural tissue anatomy and microstructure, while functional imaging captures dynamic patterns of neural…

Methodology · Statistics 2026-03-24 Sakul Mahat , Sharmistha Guha , Jessica Bernard

Dynamic networks have been increasingly used to characterize brain connectivity that varies during resting and task states. In such characterizations, a connectivity network is typically measured at each time point for a subject over a…

Methodology · Statistics 2023-03-23 Maoyu Zhang , Biao Cai , Wenlin Dai , Dehan Kong , Hongyu Zhao , Jingfei Zhang

Functional connectivity refers to the temporal statistical relationship between spatially distinct brain regions and is usually inferred from the time series coherence/correlation in brain activity between regions of interest. In human…

Machine Learning · Statistics 2015-03-02 Shaurabh Nandy , Richard M. Golden

Individual differences in human intelligence can be modeled and predicted from in vivo neurobiological connectivity. Many established modeling frameworks for predicting intelligence, however, discard higher-order information about…

Neurons and Cognition · Quantitative Biology 2022-03-07 Evan D. Anderson , Ramsey Wilcox , Anuj Nayak , Christopher Zwilling , Pablo Robles-Granda , Been Kim , Lav R. Varshney , Aron K. Barbey

Currently, connectomes (e.g., functional or structural brain graphs) can be estimated in humans at $\approx 1~mm^3$ scale using a combination of diffusion weighted magnetic resonance imaging, functional magnetic resonance imaging and…

Recent advances in molecular and genetic research have identified a diverse range of brain tumor sub-types, shedding light on differences in their molecular mechanisms, heterogeneity, and origins. The present study performs whole-brain…

Neurons and Cognition · Quantitative Biology 2024-07-26 Debanjali Bhattacharya , Ninad Aithal , Manish Jayswal , Neelam Sinha

Diffusion MRI (dMRI) tractography enables in vivo mapping of brain structural connections, but traditional connectome generation is time-consuming and requires gray matter parcellation, posing challenges for large-scale studies. We…

Image and Video Processing · Electrical Eng. & Systems 2025-06-12 Marcus J. Vroemen , Yuqian Chen , Yui Lo , Tengfei Xue , Weidong Cai , Fan Zhang , Josien P. W. Pluim , Lauren J. O'Donnell

There has been increasing interests in learning resting-state brain functional connectivity of autism disorders using functional magnetic resonance imaging (fMRI) data. The data in a standard brain template consist of over 200,000 voxel…

Methodology · Statistics 2016-03-22 Jichun Xie , Jian Kang

Predicting the evolution of the brain network, also called connectome, by foreseeing changes in the connectivity weights linking pairs of anatomical regions makes it possible to spot connectivity-related neurological disorders in earlier…

Machine Learning · Computer Science 2021-09-17 Şeymanur Aktı , Doğay Kamar , Özgür Anıl Özlü , Ihsan Soydemir , Muhammet Akcan , Abdullah Kul , Islem Rekik
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