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We consider the problem of controlling an SIR-model epidemic by temporarily reducing the rate of contact within a population. The control takes the form of a multiplicative reduction in the contact rate of infectious individuals. The…

Optimization and Control · Mathematics 2021-06-29 David I. Ketcheson

Delayed processes are ubiquitous in biological systems and are often characterized by delay differential equations (DDEs) and their extension to include stochastic effects. DDEs do not explicitly incorporate intermediate states associated…

Quantitative Methods · Quantitative Biology 2016-09-28 Jingchen Feng , Stuart Sevier , Bin Huang , Dongya Jia , Herbert Levine

We consider the problem of modifying a network topology in such a way as to delay the propagation of a disease with minimal disruption of the network capacity to reroute goods/items/passengers. We find an approximate solution to the…

Physics and Society · Physics 2022-04-15 Paolo Bartesaghi , Ernesto Estrada

In this paper, we explore the solvability and the optimal control problem for a compartmental model based on reaction-diffusion partial differential equations describing a transmissible disease. The nonlinear model takes into account the…

Optimization and Control · Mathematics 2023-08-25 Pierluigi Colli , Gianni Gilardi , Gabriela Marinoschi

A model of reactive social distancing in epidemics is proposed, in which the infection rate changes with the number infected. The final-size equation for the total number that the epidemic will infect can be derived analytically, as can the…

Populations and Evolution · Quantitative Biology 2020-03-19 Rose Baker

We present two epidemiological models, which extend the classical SEIR model by accounting for the effect of indiscriminate quarantining, isolation of infected individuals based on testing and the presence of asymptomatic individuals. Given…

Dynamical Systems · Mathematics 2020-11-30 Zuzana Chladná , Jana Kopfová , Dmitrii Rachinskii , Pavel Štepánek

We study the impact of parameter estimation and state measurement errors on a control framework for optimally mitigating the spread of epidemics. We capture the epidemic spreading process using a susceptible-infected-removed (SIR) epidemic…

Systems and Control · Electrical Eng. & Systems 2024-08-08 Baike She , Lei Xin , Shreyas Sundaram , Philip E. Paré

In this study, we present a new epidemiological model, with contamination from confirmed and unreported. We also compute equilibria and study their stability without intervention strategies. Optimal control theory has proven to be a…

Populations and Evolution · Quantitative Biology 2020-08-14 Fulgence Mansal , Mouhamadou A. M. T. Baldé , Alpha O. Bah

In the framework of homogeneous susceptible-infected-recovered (SIR) models, we use a control theory approach to identify optimal pandemic mitigation strategies. We derive rather general conditions for reaching herd immunity while…

Populations and Evolution · Quantitative Biology 2021-07-05 Prakhar Godara , Stephan Herminghaus , Knut M. Heidemann

In this paper, we consider the impact of time delay by media on the control of the disease. We set up a class of SISM epidemic model with the time delay and the cumulative density of awareness caused by media. The sufficient condition of…

Populations and Evolution · Quantitative Biology 2016-09-14 Dongmei Li , Yue Wu , Panpan Wen , Weihua Liu

We improve a recent mathematical model for cholera by adding a time delay that represents the time between the instant at which an individual becomes infected and the instant at which he begins to have symptoms of cholera disease. We prove…

Optimization and Control · Mathematics 2022-08-03 Ana P. Lemos-Paiao , Helmut Maurer , Cristiana J. Silva , Delfim F. M. Torres

In real social networks, person-to-person interactions are known to be heterogeneous, which can affect the way a disease spreads through a population, reaches a tipping point in the fraction of infected individuals, and becomes an epidemic.…

Physics and Society · Physics 2020-05-12 Ignacio A. Perez , Paul A. Trunfio , Cristian E. La Rocca , Lidia A. Braunstein

In this article a space-dependent epidemic model equipped with a constant latency period is examined. We construct a delay partial integro-differential equation and show that its solution possesses some biologically reasonable features. We…

Numerical Analysis · Mathematics 2022-08-02 B. Takács , I. Faragó , R. Horváth , D. Repovš

A key problem in modelling the evolution dynamics of infectious diseases is the mathematical representation of the mechanism of transmission of the contagion. Models with a finite number of subpopulations can be described via systems of…

Optimization and Control · Mathematics 2017-03-09 Sebastian Anita , Vincenzo Capasso

In this study, we present an integro-differential model to simulate the local spread of infections. The model incorporates a standard susceptible-infected-recovered (\textit{SIR}-) model enhanced by an integral kernel, allowing for…

Dynamical Systems · Mathematics 2023-07-20 Moritz Schäfer , Karol Niedzielewski , Thomas Götz , Tyll Krüger

In this article we propose a compartmental model for the dynamics of Coronavirus Disease 2019 (COVID-19). We take into account the presence of asymptomatic infections and the main policies that have been adopted so far to contain the…

Populations and Evolution · Quantitative Biology 2020-05-18 M. Soledad Aronna , Roberto Guglielmi , Lucas M. Moschen

Epidemic control is of great importance for human society. Adjusting interacting partners is an effective individualized control strategy. Intuitively, it is done either by shortening the interaction time between susceptible and infected…

Populations and Evolution · Quantitative Biology 2016-12-28 Bin Wu , Shanjun Mao , Jiazeng Wang , Da Zhou

A delayed term in a differential equation reflects the fact that information takes significant time to travel from one place to another within a process being studied. Despite de apparent similarity with ordinary differential equations,…

Dynamical Systems · Mathematics 2023-08-24 Gregory Kozyreff

The main focus of this chapter is on public health control strategies which are currently the main way to mitigate COVID-19 pandemic. We introduce and compare compartmental models of increasing complexity for COVID-19 transmission to…

Populations and Evolution · Quantitative Biology 2020-12-14 Redouane Qesmi , Aayah Hammoumi

In this work, we develop a spatial SEIAR-type epidemic model considering a quarantined population (denoted as Q), which we call the SQEIAR model. The dynamics of the SQEIAR model are described by six Partial Differential Equations (PDEs)…

Dynamical Systems · Mathematics 2025-01-27 Elghandouri Mohammed , Ezzinbi Khalil , Youness Mezzan