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For centuries isolation has been the main control strategy of unforeseen epidemic outbreaks. When implemented in full and without delay, isolation is very effective. However, flawless implementation is seldom feasible in practice. We…

Populations and Evolution · Quantitative Biology 2019-01-23 Lai-Sang Young , Stefan Ruschel , Serhiy Yanchuk , Tiago Pereira

Diagnostic testing followed by isolation of identified cases with subsequent tracing and quarantine of close contacts - often referred to as test-trace-isolate-and-quarantine (TTIQ) strategy - is one of the cornerstone measures of…

Populations and Evolution · Quantitative Biology 2024-03-14 Julian Heidecke , Jan Fuhrmann , Maria Vittoria Barbarossa

We study an SEIQR (Susceptible-Exposed-Infectious-Quarantined-Recovered) model for an infectious disease, with time delays for latency and an asymptomatic phase. For fast pandemics where nobody has prior immunity and everyone has immunity…

Populations and Evolution · Quantitative Biology 2020-04-09 C. P. Vyasarayani , Anindya Chatterjee

This paper introduces a new optimal control model to describe and control the dynamics of infectious diseases. In the present model, the average time of isolation (i.e. hospitalization) of infectious population is the main time-dependent…

Optimization and Control · Mathematics 2015-05-06 Robin J. Evans , Musa Mammadov

This paper introduces a spatiotemporal SEIQR epidemic model governed by a system of reaction-diffusion partial differential equations that incorporates optimal control strategies. The model captures the transmission dynamics of an…

Dynamical Systems · Mathematics 2025-07-29 Achraf Zinihi , Matthias Ehrhardt , Moulay Rchid Sidi Ammi

Our paper investigates distributions of exposed and infectious time periods in an epidemic model and how applying a disease control strategy affects the model's accuracy. While ordinary differential equations are widely used for their…

Populations and Evolution · Quantitative Biology 2018-09-28 Adrienna Bingham , Leah B. Shaw

We have derived the governing equations for an SIR model with delay terms in both the infectivity and recovery of the disease. The equations are derived by modelling the dynamics as a continuous time random walk, where individuals move…

Dynamical Systems · Mathematics 2024-10-14 Christopher N. Angstmann , Stuart-James M. Burney , Anna V. McGann , Zhuang Xu

For preventing the spread of epidemics such as the coronavirus disease COVID-19, social distancing and the isolation of infected persons are crucial. However, existing reaction-diffusion equations for epidemic spreading are incapable of…

Populations and Evolution · Quantitative Biology 2020-11-18 Michael te Vrugt , Jens Bickmann , Raphael Wittkowski

Case isolation, that is, detection and isolation of infected individuals in order to prevent spread, is a strategy to curb infectious disease epidemics. Here, we study the efficiency of a case isolation strategy subject to time delays in…

Optimization and Control · Mathematics 2022-09-20 Jonas Hansson , Alain Govaert , Richard Pates , Emma Tegling , Kristian Soltesz

We study a simple realistic model for describing the diffusion of an infectious disease on a population of individuals. The dynamics is governed by a single functional delay differential equation, which, in the case of a large population,…

Populations and Evolution · Quantitative Biology 2020-09-28 Luca Dell'Anna

Understanding dynamics of an infectious disease helps in designing appropriate strategies for containing its spread in a population. Recent mathematical models are aimed at studying dynamics of some specific types of infectious diseases. In…

Dynamical Systems · Mathematics 2015-02-05 P. Raja Sekhara Rao , M. Naresh Kumar

We introduce a methodology to guarantee safety against the spread of infectious diseases by viewing epidemiological models as control systems and by considering human interventions (such as quarantining or social distancing) as control…

Systems and Control · Electrical Eng. & Systems 2022-11-21 Tamas G. Molnar , Andrew W. Singletary , Gabor Orosz , Aaron D. Ames

Undulation of infection levels, usually called waves, are not well understood. In this paper we propose a mathematical model that exhibits undulation and decay towards a stable state. The model is a re-interpretation of the original…

Populations and Evolution · Quantitative Biology 2022-06-08 Niko Sauer

The spread of an infectious disease depends on intrinsic properties of the disease as well as the connectivity and actions of the population. This study investigates the dynamics of an SIR type model which accounts for human tendency to…

Dynamical Systems · Mathematics 2021-07-26 Hannah Scanlon , John Gemmer

This paper analyses the dynamics of infectious disease with a concurrent spread of disease awareness. The model includes local awareness due to contacts with aware individuals, as well as global awareness due to reported cases of infection…

Populations and Evolution · Quantitative Biology 2017-04-21 G. O. Agaba , Y. N. Kyrychko , K. B. Blyuss

This paper studies viability and control synthesis for a delayed SIR epidemic. The model integrates a constant delay representing an incubation/latency time. The control inputs model non-pharmaceutical interventions, while an intensive care…

Optimization and Control · Mathematics 2024-12-09 Dimitri Breda , Matteo Della Rossa , Lorenzo Freddi

In the world of epidemics, the mathematical modeling of disease co-infection is gaining importance due to its contributions to mathematics and public health. Because the co-infection may have a double burden on families, countries, and the…

Populations and Evolution · Quantitative Biology 2023-07-12 Anna Daniel Fome , Wolfgang Bock , Axel Klar

We approach the development of models and control strategies of susceptible-infected-susceptible (SIS) epidemic processes from the perspective of marked temporal point processes and stochastic optimal control of stochastic differential…

Optimization and Control · Mathematics 2018-12-04 Lars Lorch , Abir De , Samir Bhatt , William Trouleau , Utkarsh Upadhyay , Manuel Gomez-Rodriguez

In the wake of the 2020 COVID-19 epidemic, much work has been performed on the development of mathematical models for the simulation of the epidemic, and of disease models generally. Most works follow the susceptible-infected-removed (SIR)…

Numerical Analysis · Mathematics 2022-05-18 Nicola Guglielmi , Elisa Iacomini , Alex Viguerie

Models for control of epidemics on local, global and small-world networks are considered, with only partial information accessible about the status of individuals and their connections. The main goal of an effective control measure is to…

Physics and Society · Physics 2007-05-23 A. Kleczkowski , B. Dybiec , C. A. Gilligan
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