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We share our recent findings in an attempt to train a universal segmentation network for various cell types and imaging modalities. Our method was built on the generalized U-Net architecture, which allows the evaluation of each component…

Computer Vision and Pattern Recognition · Computer Science 2022-08-01 Tianqi Guo , Yin Wang , Luis Solorio , Jan P. Allebach

Reliable cell segmentation and classification from biomedical images is a crucial step for both scientific research and clinical practice. A major challenge for more robust segmentation and classification methods is the large variations in…

Cell Behavior · Quantitative Biology 2017-10-31 Mo Zhang , Xiang Li , Mengjia Xu , Quanzheng Li

There is an increasing interest in applying deep learning to 3D mesh segmentation. We observe that 1) existing feature-based techniques are often slow or sensitive to feature resizing, 2) there are minimal comparative studies and 3)…

Graphics · Computer Science 2018-02-09 David George , Xianghua Xie , Gary KL Tam

We propose a new multiclass weighted loss function for instance segmentation of cluttered cells. We are primarily motivated by the need of developmental biologists to quantify and model the behavior of blood T-cells which might help us in…

Computer Vision and Pattern Recognition · Computer Science 2018-10-24 Fidel A. Guerrero-Pena , Pedro D. Marrero Fernandez , Tsang Ing Ren , Mary Yui , Ellen Rothenberg , Alexandre Cunha

Although deep learning (DL) shows powerful potential in cell segmentation tasks, it suffers from poor generalization as DL-based methods originally simplified cell segmentation in detecting cell membrane boundary, lacking prominent cellular…

Image and Video Processing · Electrical Eng. & Systems 2023-03-22 Fang Hu , Xuexue Sun , Ke Qing , Fenxi Xiao , Zhi Wang , Xiaolu Fan

Fully supervised deep neural networks for segmentation usually require a massive amount of pixel-level labels which are manually expensive to create. In this work, we develop a multi-task learning method to relax this constraint. We regard…

Computer Vision and Pattern Recognition · Computer Science 2021-04-07 Rihuan Ke , Aurélie Bugeau , Nicolas Papadakis , Mark Kirkland , Peter Schuetz , Carola-Bibiane Schönlieb

Deep neural networks have enabled major progresses in semantic segmentation. However, even the most advanced neural architectures suffer from important limitations. First, they are vulnerable to catastrophic forgetting, i.e. they perform…

Computer Vision and Pattern Recognition · Computer Science 2022-02-01 Fabio Cermelli , Massimiliano Mancini , Samuel Rota Buló , Elisa Ricci , Barbara Caputo

Partially-supervised learning can be challenging for segmentation due to the lack of supervision for unlabeled structures, and the methods directly applying fully-supervised learning could lead to incompatibility, meaning ground truth is…

Computer Vision and Pattern Recognition · Computer Science 2022-06-22 Ke Zhang , Xiahai Zhuang

Semantic segmentation necessitates approaches that learn high-level characteristics while dealing with enormous amounts of data. Convolutional neural networks (CNNs) can learn unique and adaptive features to achieve this aim. However, due…

Computer Vision and Pattern Recognition · Computer Science 2023-07-19 Hasan AlMarzouqi , Lyes Saad Saoud

Automatic segmentation has great potential to facilitate morphological measurements while simultaneously increasing efficiency. Nevertheless often users want to edit the segmentation to their own needs and will need different tools for…

Computer Vision and Pattern Recognition · Computer Science 2018-07-24 Gustav Bredell , Christine Tanner , Ender Konukoglu

Digital pathology has recently been revolutionized by advancements in artificial intelligence, deep learning, and high-performance computing. With its advanced tools, digital pathology can help improve and speed up the diagnostic process,…

Image and Video Processing · Electrical Eng. & Systems 2024-03-28 Mohamed Elmanna , Ahmed Elsafty , Yomna Ahmed , Muhammad Rushdi , Ahmed Morsy

Deep convolutional neural networks have driven substantial advancements in the automatic understanding of images. Requiring a large collection of images and their associated annotations is one of the main bottlenecks limiting the adoption…

Computer Vision and Pattern Recognition · Computer Science 2019-08-22 Zahra Mirikharaji , Yiqi Yan , Ghassan Hamarneh

Convolutional neural networks (CNNs) achieve prevailing results in segmentation tasks nowadays and represent the state-of-the-art for image-based analysis. However, the understanding of the accurate decision-making process of a CNN is…

Image and Video Processing · Electrical Eng. & Systems 2024-10-01 Tillmann Rheude , Andreas Wirtz , Arjan Kuijper , Stefan Wesarg

In this paper, we propose an automatic brain tumor segmentation approach (e.g., PixelNet) using a pixel-level convolutional neural network (CNN). The model extracts feature from multiple convolutional layers and concatenate them to form a…

Image and Video Processing · Electrical Eng. & Systems 2022-04-26 Mobarakol Islam , Hongliang Ren

The throughput of electron microscopes has increased significantly in recent years, enabling detailed analysis of cell morphology and ultrastructure. Analysis of neural circuits at single-synapse resolution remains the flagship target of…

Computer Vision and Pattern Recognition · Computer Science 2019-08-07 Constantin Pape , Alex Matskevych , Adrian Wolny , Julian Hennies , Giula Mizzon , Marion Louveaux , Jacob Musser , Alexis Maizel , Detlev Arendt , Anna Kreshuk

Large annotated datasets are vital for training segmentation models, but pixel-level labeling is time-consuming, error-prone, and often requires scarce expert annotators, especially in medical imaging. In contrast, coarse annotations are…

Computer Vision and Pattern Recognition · Computer Science 2025-08-27 Le Zhang , Fuping Wu , Arun Thirunavukarasu , Kevin Bronik , Thomas Nichols , Bartlomiej W. Papiez

Multiplex Imaging (MI) enables the simultaneous visualization of multiple biological markers in separate imaging channels at subcellular resolution, providing valuable insights into cell-type heterogeneity and spatial organization. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-11-07 Simon Gutwein , Daria Lazic , Thomas Walter , Sabine Taschner-Mandl , Roxane Licandro

Despite the superior performance of Deep Learning (DL) on numerous segmentation tasks, the DL-based approaches are notoriously overconfident about their prediction with highly polarized label probability. This is often not desirable for…

Image and Video Processing · Electrical Eng. & Systems 2021-12-14 Sungmin Hong , Anna K. Bonkhoff , Andrew Hoopes , Martin Bretzner , Markus D. Schirmer , Anne-Katrin Giese , Adrian V. Dalca , Polina Golland , Natalia S. Rost

In image classification, visual separability between different object categories is highly uneven, and some categories are more difficult to distinguish than others. Such difficult categories demand more dedicated classifiers. However,…

Computer Vision and Pattern Recognition · Computer Science 2018-04-03 Zhicheng Yan , Hao Zhang , Robinson Piramuthu , Vignesh Jagadeesh , Dennis DeCoste , Wei Di , Yizhou Yu

Semantic segmentation demands dense pixel-level annotations, which can be prohibitively expensive - especially under extremely constrained labeling budgets. In this paper, we address the problem of low-budget active learning for semantic…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Jeongin Kim , Wonho Bae , YouLee Han , Giyeong Oh , Youngjae Yu , Danica J. Sutherland , Junhyug Noh
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