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Chemical reaction network theory provides powerful tools for rigorously understanding chemical reactions and the dynamical systems and differential equations that represent them. A frequent issue with mathematical analyses of these networks…

Quantitative Methods · Quantitative Biology 2025-12-23 Joseph M. Sauder , Bruce P. Ayati , Ryan Kinser

We consider the problem of binomiality of the steady state ideals of biochemical reaction networks. We are interested in finding polynomial conditions on the parameters such that the steady state ideal of a chemical reaction network is…

Molecular Networks · Quantitative Biology 2021-07-08 Hamid Rahkooy , Thomas Sturm

This work addresses whether a reaction network, taken with mass-action kinetics, is multistationary, that is, admits more than one positive steady state in some stoichiometric compatibility class. We build on previous work on the effect…

Molecular Networks · Quantitative Biology 2019-08-27 AmirHosein Sadeghimanesh , Elisenda Feliu

We introduce the theory of monoidal Groebner bases, a concept which generalizes the familiar notion in a polynomial ring and allows for a description of Groebner bases of ideals that are stable under the action of a monoid. The main…

Commutative Algebra · Mathematics 2011-08-25 Christopher J. Hillar , Seth Sullivant

Developed by Buchberger for commutative polynomial rings, Groebner Bases are frequently applied to solve algorithmic problems, such as the congruence problem for ideals. Until now, these ideas have been transmitted to different in part…

Rings and Algebras · Mathematics 2009-03-31 Birgit Reinert

We address the challenge of identifying all real positive steady states in chemical reaction networks (CRNs) governed by mass-action kinetics. Traditional numerical methods often require specific initial guesses and may fail to find all the…

Molecular Networks · Quantitative Biology 2025-09-29 Paola Ferrari , Sara Sommariva , Michele Piana , Federico Benvenuto , Matteo Varbaro

Chemical reaction networks are often used to model and understand biological processes such as cell signaling. Under the framework of chemical reaction network theory, a process is modeled with a directed graph and a choice of kinetics,…

Combinatorics · Mathematics 2020-12-07 Mark Curiel , Elizabeth Gross , Carlos Munoz

Zero-one reaction networks are pivotal to cellular signaling, and establishing the equivalence of such networks represents a foundational computational challenge in the realm of chemical reaction network research. Herein, we propose a…

Molecular Networks · Quantitative Biology 2026-02-03 Yue Jiao , Xiaoxian Tang

Motivated by problems from Chemical Reaction Network Theory, we investigate whether steady state ideals of reversible reaction networks are generated by binomials. We take an algebraic approach considering, besides concentrations of…

Symbolic Computation · Computer Science 2020-10-22 Hamid Rahkooy , Ovidiu Radulescu , Thomas Sturm

Many biochemical and industrial applications involve complicated networks of simultaneously occurring chemical reactions. Under the assumption of mass action kinetics, the dynamics of these chemical reaction networks are governed by systems…

Dynamical Systems · Mathematics 2014-07-15 Matthew D. Johnston

In this paper we present an algorithm for computing Groebner bases of linear ideals in a difference polynomial ring over a ground difference field. The input difference polynomials generating the ideal are also assumed to be linear. The…

Mathematical Physics · Physics 2009-11-11 Vladimir P. Gerdt

Which reaction networks, when taken with mass-action kinetics, have the capacity for multiple steady states? There is no complete answer to this question, but over the last 40 years various criteria have been developed that can answer this…

Dynamical Systems · Mathematics 2015-08-21 Badal Joshi , Anne Shiu

Chemical reaction network theory is a field of applied mathematics concerned with modeling chemical systems, and can be used in other contexts such as in systems biology to study cellular signaling pathways or epidemiology to study the…

Algebraic Geometry · Mathematics 2024-06-17 Maize Curiel , Elise Farr , Galileo Fries , Luis David García Puente , Julian Hutchins , Vuong Nguyen Hoang

The steady-state degree of a chemical reaction network is the number of complex steady-states for generic rate constants and initial conditions. One way to bound the steady-state degree is through the mixed volume of the steady-state system…

Combinatorics · Mathematics 2023-04-03 Jane Ivy Coons , Mark Curiel , Elizabeth Gross

Steady states are frequently used to investigate the long-term behaviors of (bio)-chemical systems. Recently, there has been a growing interest in network-based approaches due to their efficiency in deriving parametrizations of positive…

Dynamical Systems · Mathematics 2024-04-02 Bryan S. Hernandez , Patrick Vincent N. Lubenia

Assuming sufficiently many terms of a n-dimensional table defined over a field are given, we aim at guessing the linear recurrence relations with either constant or polynomial coefficients they satisfy. In many applications, the table terms…

Symbolic Computation · Computer Science 2021-11-19 Jérémy Berthomieu , Mohab Safey El Din

We introduce a unifying and generalizing framework for complex and detailed balanced steady states in chemical reaction network theory. To this end, we generalize the graph commonly used to represent a reaction network. Specifically, we…

Dynamical Systems · Mathematics 2017-11-21 Elisenda Feliu , Daniele Cappelletti , Carsten Wiuf

We present an efficient algorithm for computing the leading monomials of a minimal Groebner basis of a generic sequence of homogeneous polynomials. Our approach bypasses costly polynomial reductions by exploiting structural properties…

Symbolic Computation · Computer Science 2026-05-12 Kosuke Sakata , Tsuyoshi Takagi

Mathematical models are increasingly being used to understand complex biochemical systems, to analyze experimental data and make predictions about unobserved quantities. However, we rarely know how robust our conclusions are with respect to…

Molecular Networks · Quantitative Biology 2015-11-06 Elisenda Feliu , Carsten Wiuf

In this paper, we give decision criteria for normal binomial difference polynomial ideals in the univariate difference polynomial ring F{y} to have finite difference Groebner bases and an algorithm to compute the finite difference Groebner…

Symbolic Computation · Computer Science 2017-01-24 Yu-Ao Chen , Xiao-Shan Gao
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