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Cryo-electron microscopy (cryo-EM) emerges as a pivotal technology for determining the architecture of cells, viruses, and protein assemblies at near-atomic resolution. Traditional particle picking, a key step in cryo-EM, struggles with…

Biomolecules · Quantitative Biology 2024-04-17 Chentianye Xu , Xueying Zhan , Min Xu

We present the first rigorous convergence analysis of the smoothed adaptive finite element method (S-AFEM) proposed in [Mulita, Giani, Heltai: SIAM J. Sci. Comput. 43, 2021]. S-AFEM modifies the classical adaptive finite element method…

Numerical Analysis · Mathematics 2026-01-29 Philipp Bringmann , Christoph Lietz , Dirk Praetorius

Theoretical computation of cosmological observables is an intensive process, restricting the speed at which cosmological data can be analysed and cosmological models constrained, and therefore limiting research access to those with high…

Cosmology and Nongalactic Astrophysics · Physics 2026-03-11 Charlie MacMahon-Gellér , C. Danielle Leonard , Philip Bull , Markus Michael Rau

The nature of stacking faults - whether intrinsic or extrinsic - plays a pivotal role in defect-mediated processes in crystalline materials. Yet, current electron microscopy techniques for their reliable analysis remain limited to either…

Traditional image acquisition for cryo focused ion-beam scanning electron microscopy tomography often sees thousands of images being captured over a period of many hours, with immense data sets being produced. When imaging beam sensitive…

Parameter-efficient transfer learning (PETL) is proposed as a cost-effective way to transfer pre-trained models to downstream tasks, avoiding the high cost of updating entire large-scale pre-trained models (LPMs). In this work, we present…

Computer Vision and Pattern Recognition · Computer Science 2024-07-03 Yijin Huang , Pujin Cheng , Roger Tam , Xiaoying Tang

We introduce a rapid and precise analytical approach for analyzing cerebral blood flow (CBF) using Diffuse Correlation Spectroscopy (DCS) with the application of the Extreme Learning Machine (ELM). Our evaluation of ELM and existing…

Machine Learning · Computer Science 2024-02-02 Xi Chen , Zhenya Zang , Xingda Li

Cardiac disease evaluation depends on multiple diagnostic modalities: electrocardiogram (ECG) to diagnose abnormal heart rhythms, and imaging modalities such as Magnetic Resonance Imaging (MRI), Computed Tomography (CT) and echocardiography…

Signal Processing · Electrical Eng. & Systems 2024-12-25 Evariste Njomgue Fotso , Buntheng Ly , Hubert Cochet , Maxime Sermesant

Microscopy images contain rich information about how cells respond to perturbations, making them essential to applications like drug screening. To quantify images, researchers often use representation extraction methods, and recent years…

Computer Vision and Pattern Recognition · Computer Science 2026-05-18 Emre Hayir , Lorin Crawford , Alex X. Lu

Scanning transmission electron microscopy (STEM) is an extremely versatile method for studying materials on the atomic scale. Many STEM experiments are supported or validated with electron scattering simulations. However, using the…

Complete removal of cancer tumors with a negative specimen margin during lumpectomy is essential in reducing breast cancer recurrence. However, 2D specimen radiography (SR), the current method used to assess intraoperative specimen margin…

Computer Vision and Pattern Recognition · Computer Science 2025-06-27 Tyler Ward , Xiaoqin Wang , Braxton McFarland , Md Atik Ahamed , Sahar Nozad , Talal Arshad , Hafsa Nebbache , Jin Chen , Abdullah Imran

Exemplar-Free Class Incremental Learning (EFCIL) aims to learn from a sequence of tasks without having access to previous task data. In this paper, we consider the challenging Cold Start scenario in which insufficient data is available in…

Computer Vision and Pattern Recognition · Computer Science 2024-05-31 Simone Magistri , Tomaso Trinci , Albin Soutif-Cormerais , Joost van de Weijer , Andrew D. Bagdanov

Motivated by single-particle cryo-electron microscopy, multi-reference alignment (MRA) models the task of recovering an unknown signal from multiple noisy observations corrupted by random rotations. The standard approach,…

Signal Processing · Electrical Eng. & Systems 2026-01-09 Shay Kreymer , Amnon Balanov , Tamir Bendory

We propose convenient inferential methods for potentially nonstationary multivariate unobserved components models with fractional integration and cointegration. Based on finite-order ARMA approximations in the state space representation,…

Econometrics · Economics 2020-11-10 Tobias Hartl , Roland Weigand

In this paper, a novel method for edge detection of microcalcification clusters in mammogram images is presented using the concept of Fractal Dimension and Hurst co-efficient that enables to locate the microcalcifications in the mammograms.…

Computer Vision and Pattern Recognition · Computer Science 2013-05-01 P. Shanmugavadivu , V. Sivakumar

How do the neural networks distinguish two images? It is of critical importance to understand the matching mechanism of deep models for developing reliable intelligent systems for many risky visual applications such as surveillance and…

Computer Vision and Pattern Recognition · Computer Science 2021-08-13 Wenliang Zhao , Yongming Rao , Ziyi Wang , Jiwen Lu , Jie Zhou

Live-cell imaging of multiple subcellular structures is essential for understanding subcellular dynamics. However, the conventional multi-color sequential fluorescence microscopy suffers from significant imaging delays and limited number of…

Subcellular Processes · Quantitative Biology 2025-01-13 Mingyang Chen , Luhong Jin , Xuwei Xuan , Defu Yang , Yun Cheng , Ju Zhang

Automated interpretation of ultrasound imaging of the heart (echocardiograms) could improve the detection and treatment of aortic stenosis (AS), a deadly heart disease. However, existing deep learning pipelines for assessing AS from…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Zhe Huang , Xiaowei Yu , Benjamin S. Wessler , Michael C. Hughes

In real-world applications, dynamic scenarios require the models to possess the capability to learn new tasks continuously without forgetting the old knowledge. Experience-Replay methods store a subset of the old images for joint training.…

Computer Vision and Pattern Recognition · Computer Science 2024-03-13 Xinyuan Gao , Songlin Dong , Yuhang He , Xing Wei , Yihong Gong

Perhaps surprisingly, the total electron microscopy (EM) data collected to date is less than a cubic millimeter. Consequently, there is an enormous demand in the materials and biological sciences to image at greater speed and lower dosage,…

Computer Vision and Pattern Recognition · Computer Science 2016-12-06 Suhas Sreehari , S. V. Venkatakrishnan , Katherine L. Bouman , Jeffrey P. Simmons , Lawrence F. Drummy , Charles A. Bouman