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Nanopore protein sequencing produces long, noisy ionic current traces in which key molecular phases, such as protein capture and translocation, are embedded. Capture phases mark the successful entry of a protein into the pore and serve as…

Machine Learning · Computer Science 2025-11-04 Annabelle Martin , Daphne Kontogiorgos-Heintz , Jeff Nivala

Single-particle trajectories measured in microscopy experiments contain important information about dynamic processes undergoing in a range of materials including living cells and tissues. However, extracting that information is not a…

Quantitative Methods · Quantitative Biology 2019-09-25 Patrycja Kowalek , Hanna Loch-Olszewska , Janusz Szwabiński

Nanopore based sequencing has demonstrated significant potential for the development of fast, accurate, and cost-efficient fingerprinting techniques for next generation molecular detection and sequencing. We propose a specific multi-layered…

Mesoscale and Nanoscale Physics · Physics 2014-05-15 Towfiq Ahmed , Jason T. Haraldsen , John J. Rehr , Massimiliano Di Ventra , Ivan K. Schuller , Alexander V. Balatsky

Temporary changes in electrical resistance of a nanopore sensor caused by translocating target analytes are recorded as a sequence of pulses on current traces. Prevalent algorithms for feature extraction in pulse-like signals lack…

Signal Processing · Electrical Eng. & Systems 2021-05-11 Dario Dematties , Chenyu Wen , Mauricio David Pérez , Dian Zhou , Shi-Li Zhang

Depth is a vital piece of information for autonomous vehicles to perceive obstacles. Due to the relatively low price and small size of monocular cameras, depth estimation from a single RGB image has attracted great interest in the research…

Robotics · Computer Science 2021-11-25 Xingshuai Dong , Matthew A. Garratt , Sreenatha G. Anavatti , Hussein A. Abbass

Object segmentation and structure localization are important steps in automated image analysis pipelines for microscopy images. We present a convolution neural network (CNN) based deep learning architecture for segmentation of objects in…

Computer Vision and Pattern Recognition · Computer Science 2019-01-24 Shan E Ahmed Raza , Linda Cheung , Muhammad Shaban , Simon Graham , David Epstein , Stella Pelengaris , Michael Khan , Nasir M. Rajpoot

Convolutional neural networks (CNNs) are widely used for image recognition and text analysis, and have been suggested for application on one-dimensional data as a way to reduce the need for pre-processing steps. Pre-processing is an…

Machine Learning · Computer Science 2020-05-18 Ine L. Jernelv , Dag Roar Hjelme , Yuji Matsuura , Astrid Aksnes

Deep learning has established many new state of the art solutions in the last decade in areas such as object, scene and speech recognition. In particular Convolutional Neural Network (CNN) is a category of deep learning which obtains…

Computer Vision and Pattern Recognition · Computer Science 2016-09-26 Vincent Andrearczyk , Paul F. Whelan

This research presents a machine-learning approach for tumor detection in medical images using convolutional neural networks (CNNs). The study focuses on preprocessing techniques to enhance image features relevant to tumor detection,…

Image and Video Processing · Electrical Eng. & Systems 2024-03-01 Ha Anh Vu

The Convolution Neural Network (CNN) has demonstrated the unique advantage in audio, image and text learning; recently it has also challenged Recurrent Neural Networks (RNNs) with long short-term memory cells (LSTM) in sequence-to-sequence…

Computation and Language · Computer Science 2017-12-29 Qiming Chen , Ren Wu

Translocation event detection from raw nanopore current signals is a fundamental step in nanopore signal analysis. Traditional data analysis methods rely on user-defined parameters to extract event information, making the interpretation of…

Signal Processing · Electrical Eng. & Systems 2025-04-09 Jaise Johnson , Chinmayi R Galigekere , Manoj M Varma

With the improvement of computer performance and the increase of data volume, the object detection based on convolutional neural network (CNN) has become the main algorithm for object detection. This paper summarizes the research progress…

Computer Vision and Pattern Recognition · Computer Science 2020-07-28 Wei Zhang , Zuoxiang Zeng

Artificial neural network (ANN) ability to learn, correct errors, and transform a large amount of raw data into useful medical decisions for treatment and care have increased its popularity for enhanced patient safety and quality of care.…

Machine Learning · Computer Science 2021-12-08 Muhammad Azeem , Shumaila Javaid , Hamza Fahim , Nasir Saeed

Sentiment analysis is known as one of the most crucial tasks in the field of natural language processing and Convolutional Neural Network (CNN) is one of those prominent models that is commonly used for this aim. Although convolutional…

Computation and Language · Computer Science 2021-02-24 Hossein Sadr , Mozhdeh Nazari Solimandarabi , Mir Mohsen Pedram , Mohammad Teshnehlab

Most modern convolutional neural networks (CNNs) used for object recognition are built using the same principles: Alternating convolution and max-pooling layers followed by a small number of fully connected layers. We re-evaluate the state…

Machine Learning · Computer Science 2015-04-14 Jost Tobias Springenberg , Alexey Dosovitskiy , Thomas Brox , Martin Riedmiller

Proteins are the active working horses in our body. These biomolecules perform all vital cellular functions from DNA replication and general biosynthesis to metabolic signaling and environmental sensing. While static 3D structures are now…

Quantitative Methods · Quantitative Biology 2020-10-16 Sonja Schmid , Cees Dekker

Time series anomaly detection plays a critical role in automated monitoring systems. Most previous deep learning efforts related to time series anomaly detection were based on recurrent neural networks (RNN). In this paper, we propose a…

Machine Learning · Computer Science 2019-06-03 Tailai Wen , Roy Keyes

The detection of biomolecules at the single molecular level have important applications in the fields of biosensing and biomedical diagnosis. Solid state nanopore (SS-nanopore) is an effective tool to perform the single molecular detection,…

Biological Physics · Physics 2022-10-14 Jing Yang , Juan Wang , Ranfeng Wu , Yiming Chen , Cheng Zhang

We describe the class of convexified convolutional neural networks (CCNNs), which capture the parameter sharing of convolutional neural networks in a convex manner. By representing the nonlinear convolutional filters as vectors in a…

Machine Learning · Computer Science 2016-09-06 Yuchen Zhang , Percy Liang , Martin J. Wainwright

In this era of artificial intelligence, deep neural networks like Convolutional Neural Networks (CNNs) have emerged as front-runners, often surpassing human capabilities. These deep networks are often perceived as the panacea for all…

Computer Vision and Pattern Recognition · Computer Science 2023-11-15 Neeraj Kumar Singh , Nikhil R. Pal
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