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We propose an algorithm for optimizations in which the gradients contain stochastic noise. This arises, for example, in structural optimizations when computations of forces and stresses rely on methods involving Monte Carlo sampling, such…

Materials Science · Physics 2022-11-30 Siyuan Chen , Shiwei Zhang

AI algorithms have proven to be excellent predictors of protein structure, but whether and how much these algorithms can capture the underlying physics remains an open question. Here, we aim to test this question using the Alphafold2 (AF)…

Biomolecules · Quantitative Biology 2024-07-22 John M Mcbride , Tsvi Tlusty

The accurate prediction of solid-solid structural phase transitions at finite temperature is a challenging task, since the dynamics is so slow that direct simulations of the phase transitions by first-principles (FP) methods are typically…

Materials Science · Physics 2021-05-25 Peitao Liu , Carla Verdi , Ferenc Karsai , Georg Kresse

The influence of microscopic force fields on the motion of Brownian particles plays a fundamental role in a broad range of fields, including soft matter, biophysics, and active matter. Often, the experimental calibration of these force…

Computational Physics · Physics 2020-06-17 Aykut Argun , Tobias Thalheim , Stefano Bo , Frank Cichos , Giovanni Volpe

Fast prediction of the synthesizability conditions of materials remains challenging, even assuming synthesis under thermodynamic equilibrium. Approaches solely based on convex stability hulls neglect finite-temperature effects, while…

Materials Science · Physics 2026-05-27 Finja Tadge , Javier Sanz Rodrigo , Andrea Crovetto

The determination of quartic force fields for use in vibrational second-order perturbation (VPT2) calculations, currently available in numerous electronic structure packages, becomes very expensive as the size of the molecule increases,…

Chemical Physics · Physics 2026-04-23 Saikiran Kotaru , Chen Qu , Apurba Nandi , Paul L. Houston , Joel M. Bowman

Stiffness estimation is crucial for delicate object manipulation in robotic and prosthetic hands but remains challenging due to dependence on force and displacement measurement and real-time sensory integration. This study presents a…

Robotics · Computer Science 2025-07-22 Anway S. Pimpalkar , Ariel Slepyan , Nitish V. Thakor

Metallic foams are crucial to many emerging applications, among them shielding against hypervelocity impacts caused by micrometeoroids and orbital debris. The variability of properties at feature-scale and mesoscale lengths originating from…

Evaluating the mechanical response of fiber-reinforced composites can be extremely time consuming and expensive. Machine learning (ML) techniques offer a means for faster predictions via models trained on existing input-output pairs and…

Materials Science · Physics 2024-10-03 Yixuan Sun , Imad Hanhan , Michael D. Sangid , Guang Lin

Machine learning force fields (MLFFs) are an attractive alternative to ab-initio methods for molecular dynamics (MD) simulations. However, they can produce unstable simulations, limiting their ability to model phenomena occurring over…

Machine Learning · Computer Science 2025-02-26 Sanjeev Raja , Ishan Amin , Fabian Pedregosa , Aditi S. Krishnapriyan

We introduce machine learning models of quantum mechanical observables of atoms in molecules. Instant out-of-sample predictions for proton and carbon nuclear chemical shifts, atomic core level excitations, and forces on atoms reach…

Chemical Physics · Physics 2015-08-26 Matthias Rupp , Raghunathan Ramakrishnan , O. Anatole von Lilienfeld

We present a proof of concept that machine learning techniques can be used to predict the properties of CNOHF energetic molecules from their molecular structures. We focus on a small but diverse dataset consisting of 109 molecular…

Materials Science · Physics 2018-06-14 Daniel C. Elton , Zois Boukouvalas , Mark S. Butrico , Mark D. Fuge , Peter W. Chung

First-principles based crystal structure prediction (CSP) methods have revealed an essential tool for the discovery of new materials. However, in solids close to displacive phase transitions, which are common in ferroelectrics,…

Materials Science · Physics 2026-04-17 Hao Gao , Yue-Wen Fang , Ion Errea

Structural stability and vibrational properties of KN$_3$ have been studied under pressure using the first principles calculations based on the density functional theory (DFT) as well as with semi empirical dispersion correction to the DFT…

Materials Science · Physics 2013-11-08 K. Ramesh Babu , G. Vaitheeswaran

First-principles based modeling on phonon dynamics and transport using density functional theory and Boltzmann transport equation has proven powerful in predicting thermal conductivity of crystalline materials, but it remains unfeasible for…

Materials Science · Physics 2019-07-23 Xin Qian , Shenyou Peng , Xiaobo Li , Yujie Wei , Ronggui Yang

The computational prediction of atomistic structure is a long-standing problem in physics, chemistry, materials, and biology. Within conventional force-field or {\em ab initio} calculations, structure is determined through energy…

Chemical Physics · Physics 2021-09-15 Dominik Lemm , Guido Falk von Rudorff , O. Anatole von Lilienfeld

It was recently demonstrated that two machine-learning architectures, reservoir computing and time-delayed feed-forward neural networks, can be exploited for detecting the Earth's anomaly magnetic field immersed in overwhelming complex…

Signal Processing · Electrical Eng. & Systems 2024-05-30 Mohammadamin Moradi , Zheng-Meng Zhai , Aaron Nielsen , Ying-Cheng Lai

Predicting and interpreting thermal performance under oscillating flow in porous structures remains a critical challenge due to the complex coupling between fluid dynamics and geometric features. This study introduces a data-driven…

Fluid Dynamics · Physics 2025-09-16 Lichang Zhu , Laura Schaefer , Leitao Chen , Ben Xu

The native structures of proteins, except for notable exceptions of intrinsically disordered proteins, in general take their most stable conformation in the physiological condition to maintain their structural framework so that their…

Biomolecules · Quantitative Biology 2021-10-26 Lyman Monroe , Daisuke Kihara

We study vibrational statistics in current-carrying model molecular junctions using master equation approach. Especially, we concentrate on the validity of using an effective temperature $T_{\rm eff}$ to characterize the nonequilibrium…

Mesoscale and Nanoscale Physics · Physics 2020-08-20 Tao Wang , Lei-Lei Nian , Jing-Tao Lü