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The de novo assembly of large, complex genomes is a significant challenge with currently available DNA sequencing technology. While many de novo assembly software packages are available, comparatively little attention has been paid to…

Genomics · Quantitative Biology 2013-07-31 Jared T. Simpson

In a controlled experiment of sequence-to-sequence approaches for the task of sentence correction, we find that character-based models are generally more effective than word-based models and models that encode subword information via…

Computation and Language · Computer Science 2017-07-31 Allen Schmaltz , Yoon Kim , Alexander M. Rush , Stuart M. Shieber

A basic problem in metagenomics is to assign a sequenced read to the correct species in the reference collection. In typical applications in genomic epidemiology and viral metagenomics the reference collection consists of set of species…

Data Structures and Algorithms · Computer Science 2020-06-11 Dustin Cobas , Veli Mäkinen , Massimiliano Rossi

The rapidly changing landscape of sequencing technologies brings new opportunities to genomics research. Longer sequence reads and higher sequence throughput coupled with ever-improving base accuracy and decreasing per-base cost is now…

Genomics · Quantitative Biology 2022-09-20 René L. Warren

Word alignment over parallel corpora has a wide variety of applications, including learning translation lexicons, cross-lingual transfer of language processing tools, and automatic evaluation or analysis of translation outputs. The great…

Computation and Language · Computer Science 2021-08-13 Zi-Yi Dou , Graham Neubig

We present an efficient phylogenetic reconstruction algorithm allowing insertions and deletions which provably achieves a sequence-length requirement (or sample complexity) growing polynomially in the number of taxa. Our algorithm is…

Probability · Mathematics 2013-02-25 Constantinos Daskalakis , Sebastien Roch

While utilizing syntactic tools such as parts-of-speech (POS) tagging has helped us understand sentence structures and their distribution across diverse corpora, it is quite complex and poses a challenge in natural language processing…

Computation and Language · Computer Science 2025-12-15 Abhijeet Sahdev

Sequence-to-sequence translation methods based on generation with a side-conditioned language model have recently shown promising results in several tasks. In machine translation, models conditioned on source side words have been used to…

Computation and Language · Computer Science 2015-08-21 Kaisheng Yao , Geoffrey Zweig

Aligning large language models to handle instructions with extremely long contexts has yet to be fully investigated. Previous studies have attempted to scale up the available data volume by synthesizing long instruction-following samples,…

Computation and Language · Computer Science 2025-09-16 Shuzheng Si , Haozhe Zhao , Gang Chen , Yunshui Li , Kangyang Luo , Chuancheng Lv , Kaikai An , Fanchao Qi , Baobao Chang , Maosong Sun

After a period of decrease, interest in word alignments is increasing again for their usefulness in domains such as typological research, cross-lingual annotation projection, and machine translation. Generally, alignment algorithms only use…

Computation and Language · Computer Science 2022-08-11 Ayyoob Imani , Lütfi Kerem Şenel , Masoud Jalili Sabet , François Yvon , Hinrich Schütze

Disease-gene association through Genome-wide association study (GWAS) is an arduous task for researchers. Investigating single nucleotide polymorphisms (SNPs) that correlate with specific diseases needs statistical analysis of associations.…

Quantitative Methods · Quantitative Biology 2020-12-21 Sezin Kircali Ata , Min Wu , Yuan Fang , Le Ou-Yang , Chee Keong Kwoh , Xiao-Li Li

Neural dependency parsing has achieved remarkable performance for low resource morphologically rich languages. It has also been well-studied that morphologically rich languages exhibit relatively free word order. This prompts a fundamental…

Computation and Language · Computer Science 2025-07-22 Pretam Ray , Jivnesh Sandhan , Amrith Krishna , Pawan Goyal

LLM alignment ensures that large language models behave safely and effectively by aligning their outputs with human values, goals, and intentions. Aligning LLMs employ huge amounts of data, computation, and time. Moreover, curating data…

Machine Learning · Computer Science 2025-02-19 Amrit Khera , Rajat Ghosh , Debojyoti Dutta

The problem of RNA secondary structure design (also called inverse folding) is the following: given a target secondary structure, one aims to create a sequence that folds into, or is compatible with, a given structure. In several practical…

Quantitative Methods · Quantitative Biology 2013-08-02 Yu Zhou , Yann Ponty , Stéphane Vialette , Jérôme Waldispühl , Yi Zhang , Alain Denise

Parallel corpora have driven great progress in the field of Text Simplification. However, most sentence alignment algorithms either offer a limited range of alignment types supported, or simply ignore valuable clues present in comparable…

Computation and Language · Computer Science 2016-12-14 Gustavo Henrique Paetzold , Lucia Specia

Computational approaches in historical linguistics have been increasingly applied during the past decade and many new methods that implement parts of the traditional comparative method have been proposed. Despite these increased efforts,…

Computation and Language · Computer Science 2022-04-12 Johann-Mattis List , Robert Forkel , Nathan W. Hill

Conformance checking encompasses a body of process mining techniques which aim to find and describe the differences between a process model capturing the expected process behavior and a corresponding event log recording the observed…

Software Engineering · Computer Science 2022-03-29 Daniel Reißner , Abel Armas-Cervantes , Marcello La Rosa

The Third-Generation in DNA sequencing has emerged in the last few years using new technologies that allow the production of long-read sequences. Applications of the Third-Generation sequencing enable real-time and on-site data production,…

Populations and Evolution · Quantitative Biology 2019-02-26 Hyunjin Shim

Large Language Models (LLMs) are prone to generating content that exhibits gender biases, raising significant ethical concerns. Alignment, the process of fine-tuning LLMs to better align with desired behaviors, is recognized as an effective…

Computation and Language · Computer Science 2024-12-17 Tao Zhang , Ziqian Zeng , Yuxiang Xiao , Huiping Zhuang , Cen Chen , James Foulds , Shimei Pan

Generative Adversarial Networks (GANs) have been shown to aid in the creation of artificial data in situations where large amounts of real data are difficult to come by. This issue is especially salient in the computational linguistics…

Computation and Language · Computer Science 2022-10-27 Isaac Wasserman