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Retrieval-Augmented Generation (RAG) has become a foundational component of modern AI systems, yet it introduces significant privacy risks by exposing user queries to service providers. To address this, we introduce PIR-RAG, a practical…

Information Retrieval · Computer Science 2025-09-29 Baiqiang Wang , Qian Lou , Mengxin Zheng , Dongfang Zhao

The goal of this chapter is to present a survey of homomorphic encryption techniques and their applications. After a detailed discussion on the introduction and motivation of the chapter, we present some basic concepts of cryptography. The…

Cryptography and Security · Computer Science 2021-09-03 Jaydip Sen

In recent years, Semantic Communication (SemCom), which aims to achieve efficient and reliable transmission of meaning between agents, has garnered significant attention from both academia and industry. To ensure the security of…

Cryptography and Security · Computer Science 2026-01-06 Rui Meng , Dayu Fan , Haixiao Gao , Yifan Yuan , Bizhu Wang , Xiaodong Xu , Mengying Sun , Chen Dong , Xiaofeng Tao , Ping Zhang , Dusit Niyato

The projected increase of genotyping in the clinic and the rise of large genomic databases has led to the possibility of using patient medical data to perform genomewide association studies (GWAS) on a larger scale and at a lower cost than…

Quantitative Methods · Quantitative Biology 2016-04-18 Sean Simmons , Cenk Sahinalp , Bonnie Berger

Continuous authentication utilizes automatic recognition of certain user features for seamless and passive authentication without requiring user attention. Such features can be divided into categories of physiological biometrics and…

Cryptography and Security · Computer Science 2022-09-15 Ahmed Fraz Baig , Sigurd Eskeland

Homomorphic encryption is a powerful cryptographic tool that enables secure computations on the private data. It evaluates any function for any operation securely on the encrypted data without knowing its corresponding plaintext. For…

Cryptography and Security · Computer Science 2025-09-18 Giovanni Giuseppe Grimaldi

Clinical adoption of human genome sequencing requires methods with known accuracy of genotype calls at millions or billions of positions across a genome. Previous work showing discordance amongst sequencing methods and algorithms has made…

Genomics · Quantitative Biology 2014-02-18 Justin M. Zook , Brad Chapman , Jason Wang , David Mittelman , Oliver Hofmann , Winston Hide , Marc Salit

Encryption provides a method to protect data outsourced to a DBMS provider, e.g., in the cloud. However, performing database operations over encrypted data requires specialized encryption schemes that carefully balance security and…

Cryptography and Security · Computer Science 2021-03-11 Masoumeh Shafieinejad , Suraj Gupta , Jin Yang Liu , Koray Karabina , Florian Kerschbaum

Deep-learning-as-a-service is a novel and promising computing paradigm aiming at providing machine/deep learning solutions and mechanisms through Cloud-based computing infrastructures. Thanks to its ability to remotely execute and train…

Machine Learning · Computer Science 2020-03-31 Simone Disabato , Alessandro Falcetta , Alessio Mongelluzzo , Manuel Roveri

Computational complexity is a key limitation of genomic analyses. Thus, over the last 30 years, researchers have proposed numerous fast heuristic methods that provide computational relief. Comparing genomic sequences is one of the most…

Searchable Encryption (SE) is a technique that allows Cloud Service Providers (CSPs) to search over encrypted datasets without learning the content of queries and records. In recent years, many SE schemes have been proposed to protect…

Cryptography and Security · Computer Science 2019-09-27 Shujie Cui , Xiangfu Song , Muhammad Rizwan Asghar , Steven D Galbraith , Giovanni Russello

Recent years have witnessed the adoption of differential privacy (DP) in practical database systems like PINQ, FLEX, and PrivateSQL. Such systems allow data analysts to query sensitive data while providing a rigorous and provable privacy…

Databases · Computer Science 2023-09-20 Shufan Zhang , Xi He

The use of synthetic data in health applications raises privacy concerns, yet the lack of open frameworks for privacy evaluations has slowed its adoption. A major challenge is the absence of accessible benchmark datasets for evaluating…

Machine Learning · Computer Science 2026-01-21 Bing Hu , Yixin Li , Asma Bahamyirou , Helen Chen

In the digital era, users share their personal data with service providers to obtain some utility, e.g., access to high-quality services. Yet, the induced information flows raise privacy and integrity concerns. Consequently, cautious users…

Cryptography and Security · Computer Science 2021-01-13 Sylvain Chatel , Apostolos Pyrgelis , Juan R. Troncoso-Pastoriza , Jean-Pierre Hubaux

A typical setup in many machine learning scenarios involves a server that holds a model and a user that possesses data, and the challenge is to perform inference while safeguarding the privacy of both parties. Private Inference has been…

Information Theory · Computer Science 2023-11-27 Zirui Deng , Vinayak Ramkumar , Rawad Bitar , Netanel Raviv

New cryptographic techniques such as homomorphic encryption (HE) allow computations to be outsourced to and evaluated blindfolded in a resourceful cloud. These computations often require private data owned by multiple participants, engaging…

Cryptography and Security · Computer Science 2020-08-13 Asma Aloufi , Peizhao Hu , Yongsoo Song , Kristin Lauter

With the rapid development of cloud computing, the privacy security incidents occur frequently, especially data security issues. Cloud users would like to upload their sensitive information to cloud service providers in encrypted form…

Cryptography and Security · Computer Science 2018-12-04 Qi Wang , Dehua Zhou , Yanling Li

We propose a cheat sensitive quantum protocol to perform a private search on a classical database which is efficient in terms of communication complexity. It allows a user to retrieve an item from the server in possession of the database…

Quantum Physics · Physics 2009-11-13 Vittorio Giovannetti , Seth Lloyd , Lorenzo Maccone

Confidential databases (CDBs) are essential for enabling secure queries over sensitive data in untrusted cloud environments using confidential computing hardware. While adoption is growing, widespread deployment is hindered by high…

Cryptography and Security · Computer Science 2026-03-24 Wenxuan Huang , Zhanbo Wang , Mingyu Li

Protected database search systems cryptographically isolate the roles of reading from, writing to, and administering the database. This separation limits unnecessary administrator access and protects data in the case of system breaches.…