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Stochastic models of biochemical reaction networks are widely used to capture intrinsic noise in cellular systems. The typical formulation of these models are based on Markov processes for which there is extensive research on efficient…

Molecular Networks · Quantitative Biology 2025-12-03 Thomas P. Steele , David J. Warne

In modern neuroscience, functional magnetic resonance imaging (fMRI) has been a crucial and irreplaceable tool that provides a non-invasive window into the dynamics of whole-brain activity. Nevertheless, fMRI is limited by hemodynamic…

Signal Processing · Electrical Eng. & Systems 2024-01-26 Yamin Li , Ange Lou , Ziyuan Xu , Shiyu Wang , Catie Chang

This article introduces an R package to perform statistical analysis for task-based fMRI data at both individual and group levels. The analysis to detect brain activation at the individual level is based on modeling the fMRI signal using…

Applications · Statistics 2021-11-03 Johnatan Cardona Jiménez

Task-specific functional MRI (fMRI) images provide excellent modalities for studying the neuronal basis of cognitive processes. We use fMRI data to formulate and solve the problem of deconvolving task-specific aggregate neuronal networks…

Neurons and Cognition · Quantitative Biology 2024-07-04 Yifan Wang , Vikram Ravindra , Ananth Grama

Advances in neuroscience have enabled researchers to measure the activities of large numbers of neurons simultaneously in behaving animals. We have access to the fluorescence of each of the neurons which provides a first-order approximation…

Neurons and Cognition · Quantitative Biology 2023-07-21 Abhisek Chakraborty

Brain signals constitute the information that are processed by millions of brain neurons (nerve cells and brain cells). These brain signals can be recorded and analyzed using various of non-invasive techniques such as the…

Neurons and Cognition · Quantitative Biology 2022-01-13 Almabrok Essa , Hari Kotte

Resting-state functional magnetic resonance imaging (rsfMRI) is a powerful tool for investigating the relationship between brain function and cognitive processes as it allows for the functional organization of the brain to be captured…

Machine Learning · Computer Science 2025-02-25 Bishal Thapaliya , Esra Akbas , Jiayu Chen , Raam Sapkota , Bhaskar Ray , Pranav Suresh , Vince Calhoun , Jingyu Liu

Neuronal brain activity in response to repeated stimuli can be perceived using functional magnetic resonance imaging (fMRI). In this paper, we develop a statistical model for fMRI data that estimates both the associated haemodynamic…

Applications · Statistics 2015-01-26 Christopher J. Brignell , William J. Browne , Ian L. Dryden , Susan T. Francis

Functional magnetic resonance imaging (fMRI) has been increasingly employed to investigate functional brain activity. Many fMRI-related software/toolboxes have been developed, providing specialized algorithms for fMRI analysis. However,…

Image and Video Processing · Electrical Eng. & Systems 2024-05-13 Yuqi Fang , Junhao Zhang , Linmin Wang , Qianqian Wang , Mingxia Liu

Non-invasive cortical neural interfaces have only achieved modest performance in cortical decoding of limb movements and their forces, compared to invasive brain-computer interfaces (BCIs). While non-invasive methodologies are safer,…

Machine Learning · Computer Science 2021-03-25 Pablo Ortega , Tong Zhao , Aldo Faisal

Motivation: Recent advances in technology for brain imaging and high-throughput genotyping have motivated studies examining the influence of genetic variation on brain structure. Wang et al. (Bioinformatics, 2012) have developed an approach…

Methodology · Statistics 2016-10-18 Keelin Greenlaw , Elena Szefer , Jinko Graham , Mary Lesperance , Farouk S. Nathoo

Nonlinear function estimation is core to modern machine learning applications. In this paper, to perform nonlinear function estimation, we reduce a nonlinear inverse problem to a linear one using a polynomial kernel expansion. These kernels…

Information Theory · Computer Science 2019-10-02 Hangjin Liu , You , Zhou , Ahmad Beirami , Dror Baron

Recent studies have shown that multi-modeling methods can provide new insights into the analysis of brain components that are not possible when each modality is acquired separately. The joint representations of different modalities is a…

Neurons and Cognition · Quantitative Biology 2022-01-24 Jalal Mirakhorli

Brain networks in fMRI are typically identified using spatial independent component analysis (ICA), yet mathematical constraints such as sparse coding and positivity both provide alternate biologically-plausible frameworks for generating…

Neurons and Cognition · Quantitative Biology 2016-07-05 Jianwen Xie , Pamela K. Douglas , Ying Nian Wu , Arthur L. Brody , Ariana E. Anderson

Identifying unusual brain activity is a crucial task in neuroscience research, as it aids in the early detection of brain disorders. It is common to represent brain networks as graphs, and researchers have developed various graph-based…

Machine Learning · Computer Science 2024-10-04 Sadaf Sadeghian , Xiaoxiao Li , Margo Seltzer

This study proposes a deep learning model that effectively suppresses the false alarms in the intensive care units (ICUs) without ignoring the true alarms using single- and multimodal biosignals. Most of the current work in the literature…

Quantitative Methods · Quantitative Biology 2020-07-01 Sajad Mousavi , Atiyeh Fotoohinasab , Fatemeh Afghah

Brain-computer interface (BCI) decodes brain signals to understand user intention and status. Because of its simple and safe data acquisition process, electroencephalogram (EEG) is commonly used in non-invasive BCI. One of EEG paradigms,…

Human-Computer Interaction · Computer Science 2020-02-05 Byeong-Hoo Lee , Ji-Hoon Jeong , Kyung-Hwan Shim , Dong-Joo Kim

Parkinsons Disease is a neurological disorder and prevalent in elderly people. Traditional ways to diagnose the disease rely on in-person subjective clinical evaluations on the quality of a set of activity tests. The high-resolution…

Machine Learning · Computer Science 2020-10-16 Weijian Li , Wei Zhu , E. Ray Dorsey , Jiebo Luo

Fluorescence microscopy is widely used for the study of biological specimens. Deconvolution can significantly improve the resolution and contrast of images produced using fluorescence microscopy; in particular, Bayesian-based methods have…

Methodology · Statistics 2015-02-04 Alexander Wong , Xiao Yu Wang , Maud Gorbet

A body of recent work in modeling neural activity focuses on recovering low-dimensional latent features that capture the statistical structure of large-scale neural populations. Most such approaches have focused on linear generative models,…

Neurons and Cognition · Quantitative Biology 2016-10-26 Yuanjun Gao , Evan Archer , Liam Paninski , John P. Cunningham
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