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We propose an adaptive training scheme for unsupervised medical image registration. Existing methods rely on image reconstruction as the primary supervision signal. However, nuisance variables (e.g. noise and covisibility), violation of the…

Image and Video Processing · Electrical Eng. & Systems 2024-07-19 Xiaoran Zhang , John C. Stendahl , Lawrence Staib , Albert J. Sinusas , Alex Wong , James S. Duncan

We propose a segmentation framework that uses deep neural networks and introduce two innovations. First, we describe a biophysics-based domain adaptation method. Second, we propose an automatic method to segment white and gray matter, and…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Amir Gholami , Shashank Subramanian , Varun Shenoy , Naveen Himthani , Xiangyu Yue , Sicheng Zhao , Peter Jin , George Biros , Kurt Keutzer

We present KeyMorph, a deep learning-based image registration framework that relies on automatically detecting corresponding keypoints. State-of-the-art deep learning methods for registration often are not robust to large misalignments, are…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Alan Q. Wang , Evan M. Yu , Adrian V. Dalca , Mert R. Sabuncu

Neuronavigation is widely used in biomedical research and interventions to guide the precise placement of instruments around the head to support procedures such as transcranial magnetic stimulation. Traditional systems, however, rely on…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Ziye Xie , Oded Schlesinger , Raj Kundu , Jessica Y. Choi , Pablo Iturralde , Dennis A. Turner , Stefan M. Goetz , Guillermo Sapiro , Angel V. Peterchev , J. Matias Di Martino

In the medical field, landmark detection in MRI plays an important role in reducing medical technician efforts in tasks like scan planning, image registration, etc. First, 88 landmarks spread across the brain anatomy in the three respective…

Image and Video Processing · Electrical Eng. & Systems 2021-11-02 Muhammad Ilyas Patel , Shrey Singla , Razeem Ahmad Ali Mattathodi , Sumit Sharma , Deepam Gautam , Srinivasa Rao Kundeti

Aggregating multi-subject functional magnetic resonance imaging (fMRI) data is indispensable for generating valid and general inferences from patterns distributed across human brains. The disparities in anatomical structures and functional…

Machine Learning · Computer Science 2019-11-20 Weida Li , Mingxia Liu , Fang Chen , Daoqiang Zhang

Visual localization is a core technology for augmented reality and autonomous navigation. Recent methods combine the efficient rendering of 3D Gaussian Splatting (3DGS) with feature-based localization. These methods rely on direct matching…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Yingdong Gu , Shaocheng Yan , Zhenjun Zhao , Yuan Kou , Jianxin Luo , Pengcheng Shi , Jiayuan Li

Deformable image registration poses a challenging problem where, unlike most deep learning tasks, a complex relationship between multiple coordinate systems has to be considered. Although data-driven methods have shown promising…

Computer Vision and Pattern Recognition · Computer Science 2025-03-11 Vasiliki Sideri-Lampretsa , Nil Stolt-Ansó , Huaqi Qiu , Julian McGinnis , Wenke Karbole , Martin Menten , Daniel Rueckert

Ultrasound (US) has the unique potential to offer access to medical imaging to anyone, everywhere. Devices have become ultra-portable and cost-effective, akin to the stethoscope. Nevertheless US image quality and diagnostic efficacy are…

Signal Processing · Electrical Eng. & Systems 2024-10-18 Ruud JG van Sloun

Deformable image registration is a fundamental task in medical image analysis and plays a crucial role in a wide range of clinical applications. Recently, deep learning-based approaches have been widely studied for deformable medical image…

Image and Video Processing · Electrical Eng. & Systems 2023-07-03 Jing Zou , Noémie Debroux , Lihao Liu , Jing Qin , Carola-Bibiane Schönlieb , Angelica I Aviles-Rivero

Many registration problems are ill-posed in homogeneous or noisy regions, and dense voxel-wise decoders can be unnecessarily high-dimensional. A sparse control-point parameterisation provides a compact, smooth deformation representation…

Image and Video Processing · Electrical Eng. & Systems 2026-03-19 Wen Yan , Qianye Yang , Yipei Wang , Shonit Punwani , Mark Emberton , Vasilis Stavrinides , Yipeng Hu , Dean Barratt

Analysis of longitudinal changes in imaging studies often involves both segmentation of structures of interest and registration of multiple timeframes. The accuracy of such analysis could benefit from a tailored framework that jointly…

Computer Vision and Pattern Recognition · Computer Science 2021-02-25 Bo Li , Wiro J. Niessen , Stefan Klein , M. Arfan Ikram , Meike W. Vernooij , Esther E. Bron

Accurate registration of brain MRI scans is fundamental for cross-subject analysis in neuroscientific studies. This involves aligning both the cortical surface of the brain and the interior volume. Traditional methods treat volumetric and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-24 S. Mazdak Abulnaga , Andrew Hoopes , Malte Hoffmann , Robin Magnet , Maks Ovsjanikov , Lilla Zöllei , John Guttag , Bruce Fischl , Adrian Dalca

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

Accurately registering in-vivo two-photon and ex-vivo fluorescence micro-optical sectioning tomography images of individual neurons is critical for structure-function analysis in neuroscience. This task is profoundly challenging due to a…

Image and Video Processing · Electrical Eng. & Systems 2025-11-27 Wenwei Li , Lingyi Cai , Hui Gong , Qingming Luo , Anan Li

Accurate image registration is essential in many medical imaging applications, yet most deep registration networks provide little indication of when or where their predictions are unreliable. Existing uncertainty estimation approaches, such…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Lin Tian , Xiaoling Hu , Juan Eugenio Iglesias

This paper addresses the challenge of localization of anatomical landmarks in knee X-ray images at different stages of osteoarthritis (OA). Landmark localization can be viewed as regression problem, where the landmark position is directly…

Computer Vision and Pattern Recognition · Computer Science 2019-09-10 Aleksei Tiulpin , Iaroslav Melekhov , Simo Saarakkala

Accurate fetal growth assessment from ultrasound (US) relies on precise biometry measured by manually identifying anatomical landmarks in standard planes. Manual landmarking is time-consuming, operator-dependent, and sensitive to…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Chiara Di Vece , Zhehua Mao , Netanell Avisdris , Brian Dromey , Raffaele Napolitano , Dafna Ben Bashat , Francisco Vasconcelos , Danail Stoyanov , Leo Joskowicz , Sophia Bano

Diffeomorphic deformable image registration is one of the crucial tasks in medical image analysis, which aims to find a unique transformation while preserving the topology and invertibility of the transformation. Deep convolutional neural…

Image and Video Processing · Electrical Eng. & Systems 2022-02-09 Ameneh Sheikhjafari , Michelle Noga , Kumaradevan Punithakumar , Nilanjan Ray

Registration of partial-view 3D US volumes with MRI data is influenced by initialization. The standard of practice is using extrinsic or intrinsic landmarks, which can be very tedious to obtain. To overcome the limitations of registration…

Image and Video Processing · Electrical Eng. & Systems 2018-06-13 Julia Rackerseder , Maximilian Baust , Rüdiger Göbl , Nassir Navab , Christoph Hennersperger
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