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Crystal structure prediction (CSP) is now increasingly used in discovering novel materials with applications in diverse industries. However, despite decades of developments and significant progress in this area, there lacks a set of…

Prediction of the stable crystal structure for multinary (ternary or higher) compounds with unexplored compositions demands fast and accurate evaluation of free energies in exploring the vast configurational space. The machine-learning…

Computational Physics · Physics 2021-01-04 Changho Hong , Jeong Min Choi , Wonseok Jeong , Sungwoo Kang , Suyeon Ju , Kyeongpung Lee , Jisu Jung , Yong Youn , Seungwu Han

Organic molecular crystals underpin technologies ranging from pharmaceuticals to organic electronics, yet predicting solid-state packing of molecules remains challenging because candidate generation is combinatorial and stability is only…

Predicting phase stabilities of crystal polymorphs is central to computational materials science and chemistry. Such predictions are challenging because they first require searching for potential energy minima and then performing arduous…

Materials Science · Physics 2020-07-15 Aleks Reinhardt , Chris J. Pickard , Bingqing Cheng

Reliable and robust methods of predicting the crystal structure of a compound, based only on its chemical composition, is crucial to the study of materials and their applications. Despite considerable ongoing research efforts, crystal…

Materials Science · Physics 2017-07-26 Qi-Jun Hong , Joseph Yasi , Axel van de Walle

We have developed a software package CALYPSO (Crystal structure AnaLYsis by Particle Swarm Optimization) to predict the energetically stable/metastable crystal structures of materials at given chemical compositions and external conditions…

Materials Science · Physics 2015-06-05 Yanchao Wang , Jian Lv , Li Zhu , Yanming Ma

Fast and accurate crystal structure prediction (CSP) algorithms and web servers are highly desirable for exploring and discovering new materials out of the infinite design space. However, currently, the computationally expensive first…

Crystal Structure Prediction (csp) is one of the central and most challenging problems in materials science and computational chemistry. In csp, the goal is to find a configuration of ions in 3D space that yields the lowest potential…

Computational Complexity · Computer Science 2023-06-22 Duncan Adamson , Argyrios Deligkas , Vladimir Gusev , Igor Potapov

We have developed an efficient and reliable methodology for crystal structure prediction, merging ab initio total-energy calculations and a specifically devised evolutionary algorithm. This method allows one to predict the most stable…

Materials Science · Physics 2009-11-18 A. R. Oganov , C. W. Glass

In computational chemistry, crystal structure prediction (CSP) is an optimization problem that involves discovering the lowest energy stable crystal structure for a given chemical formula. This problem is challenging as it requires…

Machine Learning · Computer Science 2023-10-17 Han Qi , Xinyang Geng , Stefano Rando , Iku Ohama , Aviral Kumar , Sergey Levine

Accurate crystal structure prediction (CSP) requires accounting for finite-temperature and nuclear quantum effects, yet first-principles evaluation of the free energy surface (FES) remains prohibitive for high-throughput searches. We…

Materials Science · Physics 2026-04-23 Xiaoyang Wang , Yinan Wang , Wenbo Zhao , Hanyu Liu , Hao Xie , Lei Wang , Han Wang

Crystalline materials are widely used in technological applications, yet their discovery remains a significant challenge. As their properties are driven by structure, crystal structure prediction (CSP) methods play a central role in…

Machine Learning · Computer Science 2026-04-28 Stavros Gerolymatos , J. Kyle Brubaker , Martin J. A. Schuetz , Vladimir V. Gusev

We present an evaluation of CSP-MACE-{\AA}, a machine learning interatomic potential intended to replace DFT in crystal structure prediction (CSP). We decompose the total energy into separate intramolecular and intermolecular components.…

Stable or metastable crystal structures of assembled atoms can be predicted by finding the global or local minima of the energy surface within a broad space of atomic configurations. Generally, this requires repeated first-principles energy…

Due to the subtle balance of intermolecular interactions that govern structure-property relations, predicting the stability of crystal structures formed from molecular building blocks is a highly non-trivial scientific problem. A…

Chemical Physics · Physics 2022-12-26 Rose K. Cersonsky , Maria Pakhnova , Edgar A. Engel , Michele Ceriotti

We develop a method combining machine learning (ML) and density functional theory (DFT) to predict low-energy polymorphs by introducing physics-guided descriptors based on structural distortion modes. We systematically generate crystal…

Materials Science · Physics 2022-09-07 Bastien F. Grosso , Nicola A. Spaldin , Aria Mansouri Tehrani

We introduce a computational method to discover polymorphs in molecular crystals at finite temperature. The method is based on reproducing the crystallization process starting from the liquid and letting the system discover the relevant…

Chemical Physics · Physics 2020-04-10 Pablo M. Piaggi , Michele Parrinello

To extend rational materials design and discovery into the space of metastable polymorphs, rapid and reliable assessment of their lifetimes is essential. Motivated by the early work of Buerger (1951), here we investigate the routes to…

Materials Science · Physics 2018-04-04 Vladan Stevanovic , Ryan Trottier , Felix Therrien , Charles Musgrave , Aaron Holder , Peter Graf

Controlling polymorphism in molecular crystals is crucial in the pharmaceutical, dye, and pesticide industries. However, its theoretical description is extremely challenging, due to the associated long timescales ($ > 1 \, \mu s$). We…

Chemical Physics · Physics 2023-02-09 Oren Elishav , Roy Podgaetsky , Olga Meikler , Barak Hirshberg

Polymorphs in molecular crystals are often very close in energy, yet they may possess markedly different physical and chemical properties. The understanding and prediction of polymorphism is of paramount importance for a variety of…