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Graph generation has emerged as a crucial task in machine learning, with significant challenges in generating graphs that accurately reflect specific properties. Existing methods often fall short in efficiently addressing this need as they…

Self-supervised neural language models have recently achieved unprecedented success, from natural language processing to learning the languages of biological sequences and organic molecules. These models have demonstrated superior…

Adjusting the photo color to associate with some design elements is an essential way for a graphic design to effectively deliver its message and make it aesthetically pleasing. However, existing tools and previous works face a dilemma…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Zhenwei Wang , Nanxuan Zhao , Gerhard Hancke , Rynson W. H. Lau

Reinforcement learning (RL) over text representations can be effective for finding high-value policies that can search over graphs. However, RL requires careful structuring of the search space and algorithm design to be effective in this…

Machine Learning · Computer Science 2023-10-05 Raj Ghugare , Santiago Miret , Adriana Hugessen , Mariano Phielipp , Glen Berseth

Variant and gene interpretation are fundamental to personalized medicine and translational biomedicine. However, traditional approaches are manual and labor-intensive. Generative language models (LMs) can facilitate this process,…

Artificial Intelligence · Computer Science 2025-10-15 Owen Queen , Harrison G. Zhang , James Zou

Counterfactual explanations of Graph Neural Networks (GNNs) offer a powerful way to understand data that can naturally be represented by a graph structure. Furthermore, in many domains, it is highly desirable to derive data-driven global…

Machine Learning · Computer Science 2024-06-21 Danqing Wang , Antonis Antoniades , Kha-Dinh Luong , Edwin Zhang , Mert Kosan , Jiachen Li , Ambuj Singh , William Yang Wang , Lei Li

Logical rules are a popular knowledge representation language in many domains, representing background knowledge and encoding information that can be derived from given facts in a compact form. However, rule formulation is a complex process…

Artificial Intelligence · Computer Science 2020-02-13 Cristina Cornelio , Veronika Thost

The Gene Regulatory Network (GRN) of biological cells governs a number of key functionalities that enables them to adapt and survive through different environmental conditions. Close observation of the GRN shows that the structure and…

Neural and Evolutionary Computing · Computer Science 2023-10-10 Adrian Ratwatte , Samitha Somathilaka , Sasitharan Balasubramaniam , Assaf A. Gilad

Despite the success of foundation models in language and vision, molecular graph generation still lacks a unified framework for heterogeneous design tasks with reliable controllability. While reinforcement learning (RL) offers a natural…

Machine Learning · Computer Science 2026-05-18 Yihan Zhu , Yuhan Liu , Weijiang Li , Tengfei Luo , Meng Jiang

The stochastic kinetics of BRN are described by a chemical master equation (CME) and the underlying laws of mass action. The CME must be usually solved numerically by generating enough traces of random reaction events. The resulting…

Molecular Networks · Quantitative Biology 2023-06-21 Pavel Loskot

Drug Discovery is a fundamental and ever-evolving field of research. The design of new candidate molecules requires large amounts of time and money, and computational methods are being increasingly employed to cut these costs. Machine…

Machine Learning · Statistics 2021-05-28 Pietro Bongini , Monica Bianchini , Franco Scarselli

The rise of Large Language Models (LLMs) offers transformative potential for interpreting complex legal frameworks, such as Title 18 Section 175 of the US Code, which governs biological weapons. These systems hold promise for advancing…

Computation and Language · Computer Science 2025-11-13 Abha Jha , Abel Salinas , Fred Morstatter

SMILES is a linear representation of chemical structures which encodes the connection table, and the stereochemistry of a molecule as a line of text with a grammar structure denoting atoms, bonds, rings and chains, and this information can…

Machine Learning · Computer Science 2018-12-03 Arindam Paul , Dipendra Jha , Reda Al-Bahrani , Wei-keng Liao , Alok Choudhary , Ankit Agrawal

Multimodal Large Language Models (MLLMs) excel at recognizing individual visual elements and reasoning over simple linear diagrams. However, when faced with complex topological structures involving branching paths, converging flows, and…

Artificial Intelligence · Computer Science 2026-04-24 Qiang Xu , Shengyuan Bai , Yu Wang , He Cao , Leqing Chen , Yuanyuan Liu , Bin Feng , Zijing Liu , Yu Li

In this demo, we present PackageBuilder, a system that extends database systems to support package queries. A package is a collection of tuples that individually satisfy base constraints and collectively satisfy global constraints. The need…

Databases · Computer Science 2015-07-06 Matteo Brucato , Rahul Ramakrishna , Azza Abouzied , Alexandra Meliou

Molecular relational learning, whose goal is to learn the interaction behavior between molecular pairs, got a surge of interest in molecular sciences due to its wide range of applications. Recently, graph neural networks have recently shown…

Molecular Networks · Quantitative Biology 2023-07-11 Namkyeong Lee , Dongmin Hyun , Gyoung S. Na , Sungwon Kim , Junseok Lee , Chanyoung Park

Formal languages let us define the textual representation of data with precision. Formal grammars, typically in the form of BNF-like productions, describe the language syntax, which is then annotated for syntax-directed translation and…

Software Engineering · Computer Science 2015-03-19 Luis Quesada , Fernando Berzal , Juan-Carlos Cubero

Rule-based models, e.g., decision trees, are widely used in scenarios demanding high model interpretability for their transparent inner structures and good model expressivity. However, rule-based models are hard to optimize, especially on…

Machine Learning · Computer Science 2021-10-01 Zhuo Wang , Wei Zhang , Ning Liu , Jianyong Wang

Strict privacy regulations limit access to real transaction data, slowing open research in financial AI. Synthetic data can bridge this gap, but existing generators do not jointly achieve behavioral diversity and logical groundedness.…

Bilevel optimization refers to scenarios whereby the optimal solution of a lower-level energy function serves as input features to an upper-level objective of interest. These optimal features typically depend on tunable parameters of the…

Machine Learning · Computer Science 2024-03-08 Amber Yijia Zheng , Tong He , Yixuan Qiu , Minjie Wang , David Wipf