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Is it possible to estimate the dependence of a growing and dividing population on a given trait in the case where this trait is not directly accessible by experimental measurements, but making use of measurements of another variable? This…

Statistics Theory · Mathematics 2019-07-12 Marie Doumic , Adélaïde Olivier , Lydia Robert

We study the mathematical properties of a general model of cell division structured with several internal variables. We begin with a simpler and specific model with two variables, we solve the eigenvalue problem with strong or weak…

Analysis of PDEs · Mathematics 2008-10-08 Marie Doumic Jauffret

We investigate a minimal model for cell propagation involving migration along self-generated signaling gradients and cell division, which has been proposed in an earlier study. The model consists in a system of two coupled parabolic…

Analysis of PDEs · Mathematics 2022-03-11 Mete Demircigil

We model the growth of a cell population using a piecewise deterministic Markov branching tree. In this model, each cell splits into two offspring at a division rate $B(x)$, which depends on its size $x$. The size of each cell increases…

Probability · Mathematics 2024-09-06 Nathalie Krell

In this paper we study a two-level branching model for virus populations under cell division. We assume that the cells are carrying virus populations which evolve as a branching particle system with competition, while the cells split…

Probability · Mathematics 2020-12-09 Luis Osorio , Anita Winter

We give a refined description of the dominant spectrum of a non-local operator that models growth and equal mitosis of cells. More precisely we look at the spectrum in half planes at the right hand side of the first accumulation point of…

Analysis of PDEs · Mathematics 2024-09-24 Pierre Gabriel , Bruce van Brunt , Graeme Charles Wake , Ali Ashher Zaidi

Modelling, analysing and inferring triggering mechanisms in population reproduction is fundamental in many biological applications. It is also an active and growing research domain in mathematical biology. In this chapter, we review the…

Analysis of PDEs · Mathematics 2023-01-09 Marie Doumic , Marc Hoffmann

Protein distributions measured under a broad set of conditions in bacteria and yeast were shown to exhibit a common skewed shape, with variances depending quadratically on means. For bacteria these properties were reproduced by temporal…

Biological Physics · Physics 2015-10-28 Naama Brenner , C. M. Newman , Dino Osmanovic , Yitzhak Rabin , Hanna Salman , D. L. Stein

We study time continuous branching processes with exponentially distributed lifetimes, with two types of cells that proliferate according to binary fission. A range of possible system dynamics are considered, each of which is characterized…

Probability · Mathematics 2022-04-27 Nam H Nguyen , Marek Kimmel

The rate at which individual bacterial cells grow depends on the concentrations of cellular components such as ribosomes and proteins. These concentrations continuously fluctuate over time and are inherited from mother to daughter cells,…

Populations and Evolution · Quantitative Biology 2024-08-21 Yaïr Hein , Farshid Jafarpour

We consider a class of biologically-motivated stochastic processes in which a unicellular organism divides its resources (volume or damaged proteins, in particular) symmetrically or asymmetrically between its progeny. Assuming the final…

Quantitative Methods · Quantitative Biology 2016-07-20 Andrew Marantan , Ariel Amir

We study the continuous model of the localized wave propagation corresponding to the one-dimensional diatomic crystal lattice. From the mathematical point of view the problem can be described in terms of the Cauchy problem with localized…

Mathematical Physics · Physics 2025-07-15 Sergey Sergeev

We consider an evolution equation with the regularized fractional derivative of an order $\alpha \in (0,1)$ with respect to the time variable, and a uniformly elliptic operator with variable coefficients acting in the spatial variables.…

Analysis of PDEs · Mathematics 2012-06-26 Samuil D. Eidelman , Anatoly N. Kochubei

This paper theoretically analyzes a phenomenological stochastic model for bacterial growth. This model comprises cell division and the linear growth of cells, where growth rates and cell cycles are drawn from lognormal distributions. We…

Biological Physics · Physics 2016-06-28 Ken Yamamoto , Jun-ichi Wakita

The abstract Cauchy problem for the distributed order fractional evolution equation in the Caputo and in the Riemann-Liouville sense is studied for operators generating a strongly continuous one-parameter semigroup on a Banach space.…

Analysis of PDEs · Mathematics 2015-02-17 Emilia Bazhlekova

The goal of the present paper is to explore the long-time behavior of the growth-fragmentation equation formulated in the case of equal mitosis and variability in growth rate, under fairly general assumptions on the coefficients. The first…

Analysis of PDEs · Mathematics 2025-03-10 Anaïs Rat , Magali Tournus

We consider the fragmentation equation $\dfrac{\partial}{\partial t}f (t, x) = --B(x)f (t, x) + \int\_{ y=x}^{ y=\infty} k(y, x)B(y)f (t, y)dy,$ and address the question of estimating the fragmentation parameters-i.e. the division rate…

Analysis of PDEs · Mathematics 2018-06-24 Marie Doumic , Miguel Escobedo , Magali Tournus

The objective is to prove the asynchronous exponential growth of the growth-fragmentation equation in large weighted $L^1$ spaces and under general assumptions on the coefficients. The key argument is the creation of moments for the…

Analysis of PDEs · Mathematics 2020-07-22 Etienne Bernard , Pierre Gabriel

Uncovering the quantitative laws that govern the growth and division of single cells remains a major challenge. Using a unique combination of technologies that yields unprecedented statistical precision, we find that the sizes of individual…

The mean size of exponentially dividing E. coli cells cultured in different nutrient conditions is known to depend on the mean growth rate only. However, the joint fluctuations relating cell size, doubling time and individual growth rate…

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