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Diffusion models achieve strong generation quality, diversity, and distribution coverage, but their performance often comes with expensive inference. In this work, we propose Stochastic Transition-Map Distillation (STMD), a teacher-free…

Machine Learning · Computer Science 2026-05-11 George Rapakoulias , Peter Garud , Lingjiong Zhu , Panagiotis Tsiotras

Many coarse-grained models have been developed for equilibrium studies of lipid bilayer membranes. To achieve in simulations access to length-scales and time-scales difficult to attain in fully atomistic molecular dynamics, these…

Soft Condensed Matter · Physics 2023-02-28 Yaohong Wang , Jon Karl Sigurdsson , Paul J. Atzberger

Structure formation in non-equilibrium steady state conditions is poorly understood. Non-equilibrium steady state can be achieved in a system by maintaining temperature gradient. A class of cross-linked micro-gel particles,…

Soft Condensed Matter · Physics 2023-08-02 Rahul Karmakar , Jaydeb Chakrabarti

Recent far-infrared vibration-rotation tunneling (FIR-VRT) experiments pose new challenges to theory because the interpretation and prediction of such spectra requires a detailed understanding of the potential energy surface (PES) away from…

Atomic and Molecular Clusters · Physics 2009-10-31 David J. Wales

We study the Langevin dynamics of a heteropolymer by means of a mode-coupling approximation scheme, giving rise to a set of coupled integro-differential equations relating the response and correlation functions. The analysis shows that…

Disordered Systems and Neural Networks · Physics 2007-05-23 Estelle Pitard , Eugene I. Shakhnovich

Using normalizing flows and reweighting, Boltzmann Generators enable equilibrium sampling from a Boltzmann distribution, defined by an energy function and thermodynamic state. In this work, we introduce Thermodynamic Interpolation (TI),…

Chemical Physics · Physics 2024-11-18 Selma Moqvist , Weilong Chen , Mathias Schreiner , Feliks Nüske , Simon Olsson

Multi-particle collision dynamics is an appealing numerical technique aiming at simulating fluids at the mesoscopic scale. It considers molecular details in a coarse-grained fashion and reproduces hydrodynamic phenomena. Here, the…

Soft Condensed Matter · Physics 2019-03-28 H. Híjar

The problems of the intermediate-range atomic structure of glasses and of the mechanism for the glass transition are approached from the low-temperature end in terms of a scenario for the atomic organization that justifies the use of an…

Mesoscale and Nanoscale Physics · Physics 2017-05-30 Giancarlo Jug

Recently, fictitious identical particles have provided a promising way to overcome the fermion sign problem and have been used in path integral Monte Carlo (PIMC) to accurately simulate warm dense matter with up to 1000 electrons (T.…

Quantum Gases · Physics 2025-08-14 Yunuo Xiong , Shujuan Liu , Hongwei Xiong

The Langevin dynamics is a diffusion process extensively used, in particular in molecular dynamics simulations, to sample Gibbs measures. Some alternatives based on (piecewise deterministic) kinetic velocity jump processes have gained…

Numerical Analysis · Mathematics 2025-05-27 Nicolaï Gouraud , Lucas Journel , Pierre Monmarché

We introduce two new thermostats, one of Langevin type and one of gradient (Brownian) type, for rigid body dynamics. We formulate rotation using the quaternion representation of angular coordinates; both thermostats preserve the unit length…

Computational Physics · Physics 2015-06-12 R. L. Davidchack , T. E. Ouldridge , M. V. Tretyakov

Langevin Dynamics is a Stochastic Differential Equation (SDE) central to sampling and generative modeling and is implemented via time discretization. Langevin Monte Carlo (LMC), based on the Euler-Maruyama discretization, is the simplest…

Machine Learning · Computer Science 2025-10-10 Saravanan Kandasamy , Dheeraj Nagaraj

The complex Langevin method (CLM) is a promising tool to address the sign problem in quantum field theories with complex actions. However, it can converge to incorrect results even when simulations appear stable, highlighting the need for…

High Energy Physics - Lattice · Physics 2026-03-27 Anosh Joseph , Arpith Kumar

Thermodynamics of dissipative quantum systems with double-well potentials is studied by the path-integral Monte Carlo (PIMC) method without truncation to the two-state model. For efficient simulation at low temperatures, we develop a new…

Statistical Mechanics · Physics 2007-05-23 Takeshi Matsuo , Yuhei Natsume , Takeo Kato

Time evolution of tunneling phenomena in medium is studied using a standard model of environment interaction. A semiclassical formula valid at low, but finite temperatures is derived in the form of integral transform for the reduced Wigner…

High Energy Physics - Phenomenology · Physics 2007-05-23 Sh. Matsumoto , M. Yoshimura

Ring polymer molecular dynamics (RPMD) is used to directly simulate the dynamics of an excess electron in a supercritical fluid over a broad range of densities. The accuracy of the RPMD model is tested against numerically exact path…

Statistical Mechanics · Physics 2011-07-27 Thomas F. Miller

An application of impedance measurement technique (IMT) for a detection of quantum tunneling in molecular structures is investigated. A charged particle which tunnels in a two-well potential is electrically coupled to a high-quality…

Mesoscale and Nanoscale Physics · Physics 2016-08-31 Anatoly Yu. Smirnov

Splitting due to tunnelling via the potential energy barrier has played a significant role in the study of molecular spectra since the early days of spectroscopy. The observation of the ammonia doublet led to attempts to find a phosphine…

Chemical Physics · Physics 2016-09-21 Clara Sousa-Silva , Jonathan Tennyson , Sergey N. Yurchenko

Ring-polymer instanton theory has been developed to simulate the quantum dynamics of molecular systems at low temperatures. Chemical reaction rates can be obtained by locating the dominant tunneling pathway and analyzing fluctuations around…

Chemical Physics · Physics 2019-03-25 Pierre Winter , Jeremy O. Richardson

We investigate the interplay between post-translational folding and escape of two small single-domain proteins at the ribosomal exit tunnel by using Langevin dynamics with coarse-grained models. It is shown that at temperatures lower or…

Biomolecules · Quantitative Biology 2016-02-19 Bui Phuong Thuy , Trinh Xuan Hoang