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We introduce simple models of genetic regulatory networks and we proceed to the mathematical analysis of their dynamics. The models are discrete time dynamical systems generated by piecewise affine contracting mappings whose variables…

Dynamical Systems · Mathematics 2007-05-23 Ricardo Coutinho , Bastien Fernandez , Ricardo Lima , Arnaud Meyroneinc

The co-evolution of network topology and dynamics is studied in an evolutionary Boolean network model that is a simple model of gene regulatory network. We find that a critical state emerges spontaneously resulting from interplay between…

Statistical Mechanics · Physics 2007-05-23 Min Liu , Kevin E. Bassler

The human organism is an integrated network where complex physiologic systems, each with its own regulatory mechanisms, continuously interact, and where failure of one system can trigger a breakdown of the entire network. Identifying and…

Data Analysis, Statistics and Probability · Physics 2012-03-02 Amir Bashan , Ronny P. Bartsch , Jan W. Kantelhardt , Shlomo Havlin , Plamen Ch. Ivanov

The study of the interplay between the structure and dynamics of complex multilevel systems is a pressing challenge nowadays. In this paper, we use a semi-annealed approximation to study the stability properties of Random Boolean Networks…

Physics and Society · Physics 2012-10-31 Emanuele Cozzo , Alex Arenas , Yamir Moreno

Scale-free and non-computable characteristics of natural networks are found to result from the least-time dispersal of energy. To consider a network as a thermodynamic system is motivated since ultimately everything that exists can be…

General Physics · Physics 2011-06-22 Tuomo Hartonen , Arto Annila

A social choice procedure is modeled as a repeated Nash game between the social agents, who are communicating with each other through a social communication network modeled by an undirected graph. The agents' criteria for this game are…

Systems and Control · Computer Science 2021-03-02 Athanasios-Rafail Lagos , George P. Papavassilopoulos

We analyze transport on a graph with multiple constraints and where the weight of the edges connecting the nodes is a dynamical variable. The network dynamics results from the interplay between a nonlinear function of the flow, dissipation,…

Statistical Mechanics · Physics 2023-11-28 Frederic Folz , Kurt Mehlhorn , Giovanna Morigi

Empirical complex systems must differentially respond to external perturbations and, at the same time, internally distribute information to coordinate their components. While networked backbones help with the latter, they limit the…

Physics and Society · Physics 2025-04-18 Arsham Ghavasieh , Manlio De Domenico

Cellular phenotypes are determined by the dynamical activity of networks of co-regulated genes. Elucidating such networks is crucial for the understanding of normal cell physiology as well as for the dissection of complex pathologic…

Molecular Networks · Quantitative Biology 2007-05-23 Kai Wang , Nilanjana Banerjee , Adam Margolin , Ilya Nemenman , Katia Basso , Riccardo Favera , Andrea Califano

Network motifs are patterns of over-represented node interactions in a network which have been previously used as building blocks to understand various aspects of the social networks. In this paper, we use motif patterns to characterize the…

Social and Information Networks · Computer Science 2019-03-05 Soumajyoti Sarkar , Ruocheng Guo , Paulo Shakarian

This paper analyzes stochastic networks consisting of a set of finite capacity sites where different classes of individuals move according to some routing policy. The associated Markov jump processes are analyzed under a thermodynamic limit…

Probability · Mathematics 2009-09-29 Nelson Antunes , Christine Fricker , Philippe Robert , Danielle Tibi

The study of network structure has uncovered signatures of the organization of complex systems. However, there is also a need to understand how to control them; for example, identifying strategies to revert a diseased cell to a healthy…

Molecular Networks · Quantitative Biology 2016-04-19 Alexander J. Gates , Luis M. Rocha

Graphical models are a succinct way to represent the structure in probability distributions. This article analyzes the graphical model of nodal voltages in non-radial power distribution grids. Using algebraic and structural properties of…

Systems and Control · Computer Science 2020-02-28 Deepjyoti Deka , Saurav Talukdar , Michael Chertkov , Murti Salapaka

The stability of Boolean networks has attracted much attention due to its wide applications in describing the dynamics of biological systems. During the past decades, much effort has been invested in unveiling how network structure and…

Physics and Society · Physics 2018-03-21 Jiannan Wang , Sen Pei , Wei Wei , Xiangnan Feng , Zhiming Zheng

A growing set of applications consider the process of network formation by using subgraphs as a tool for generating the network topology. One of the pressing research challenges is thus to be able to use these subgraphs to understand the…

Social and Information Networks · Computer Science 2019-04-11 Soumajyoti Sarkar , Hamidreza Alvari , Paulo Shakarian

Flexible information routing fundamentally underlies the function of many biological and artificial networks. Yet, how such systems may specifically communicate and dynamically route information is not well understood. Here we identify a…

Adaptation and Self-Organizing Systems · Physics 2016-07-08 Christoph Kirst , Marc Timme , Demian Battaglia

Random Boolean networks (RBNs) are models of genetic regulatory networks. It is useful to describe RBNs as self-organizing systems to study how changes in the nodes and connections affect the global network dynamics. This article reviews…

Adaptation and Self-Organizing Systems · Physics 2010-09-24 Carlos Gershenson

An information theoretic approach inspired by quantum statistical mechanics was recently proposed as a means to optimize network models and to assess their likelihood against synthetic and real-world networks. Importantly, this method does…

Statistical Mechanics · Physics 2018-09-12 Carlo Nicolini , Vladimir Vlasov , Angelo Bifone

Consider a large Boolean network with a feed forward structure. Given a probability distribution on the inputs, can one find, possibly small, collections of input nodes that determine the states of most other nodes in the network? To answer…

Information Theory · Computer Science 2013-05-23 Reinhard Heckel , Steffen Schober , Martin Bossert

We consider a general class of stochastic networks and ask which network nodes need to be controlled, and how, to stabilize and switch between desired metastable (target) states in terms of the first and second statistical moments of the…

Adaptation and Self-Organizing Systems · Physics 2016-07-20 Dmytro Bielievtsov , Josef Ladenbauer , Klaus Obermayer