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Voltage distribution in sub-cellular micro-domains such as neuronal synapses, small protrusions or dendritic spines regulates the opening and closing of ionic channels, energy production and thus cellular homeostasis and excitability. Yet…

Subcellular Processes · Quantitative Biology 2024-07-23 Frédéric Paquin-Lefebvre , David Holcman

Voltage and charge distributions in cellular microdomains regulate communications, excitability, and signal transduction. We report here new electrical laws in a cell, which follow from a nonlinear electro-diffusion model. These newly…

Biological Physics · Physics 2017-01-03 Jerome Cartailler , Zeev Schuss , David Holcman

The flow of ions through permeable channels causes voltage drop in physiological nanodomains such as synapses, dendrites and dendritic spines, and other protrusions. How the voltage changes around channels in these nanodomains has remained…

Soft Condensed Matter · Physics 2025-01-10 Frédéric Paquin-Lefebvre , David Holcman

The distribution of voltage in sub-micron cellular domains remains poorly understood. In neurons, the voltage results from the difference in ionic concentrations which are continuously maintained by pumps and exchangers. However, it not…

Soft Condensed Matter · Physics 2020-03-26 Alexis Tricot , Igor M. Sokolov , David Holcman

Characterizing the local voltage distribution within nanophysiological domains, driven by ionic currents through membrane channels, is crucial for studying cellular activity in modern biophysics, yet it presents significant experimental and…

Soft Condensed Matter · Physics 2026-05-14 Frédéric Paquin-Lefebvre , Alejandro Barea Moreno , David Holcman

We study the electro-diffusion properties of a domain containing a cusp-shaped structure in three dimensions when one ionic specie is dominant. The mathematical problem consists in solving the steady-state Poisson-Nernst-Planck (PNP)…

Neurons and Cognition · Quantitative Biology 2017-10-09 J. Cartailler , D. Holcman

Electrical signaling in the brain plays a vital role to our existence but at the same time, the fundamental mechanism of this propagation is undeciphered. Notable advancements have been made in the numerical modeling supplementing the…

Neurons and Cognition · Quantitative Biology 2024-11-11 Rahul Gulati , Shiva Rudraraju

The transient behaviour of organic electrochemical transistors (OECT) is complex due to mixed ionic-electronic properties that play a central role in bioelectronics, sensing and neuromorphic applications. We investigate the impedance…

Materials Science · Physics 2024-08-06 Juan Bisquert , Scott T. Keene

We analyze the transport in disordered two-dimensional nanoparticle arrays. We show that the commonly used scaling hypothesis to fit the I-V curves does not describe the electronic transport in these systems. On the contrary, close to the…

Mesoscale and Nanoscale Physics · Physics 2010-11-03 V. Estevez , E. Bascones

We analyze and clarify the transport properties of a one-dimensional metallic nanoparticle array with interaction between charges restricted to charges placed in the same conductor. We study the threshold voltage, the I-V curves and the…

Mesoscale and Nanoscale Physics · Physics 2009-11-13 E. Bascones , V. Estevez , J. A. Trinidad , A. H. MacDonald

We develop a macroscopic description of the current-induced torque due to spin transfer in a layered system consisting of two ferromagnetic layers separated by a nonmagnetic layer. The description is based on i) the classical spin diffusion…

Mesoscale and Nanoscale Physics · Physics 2016-08-31 J. Barnas , A. Fert , M. Gmitra , I. Weymann , V. K. Dugaev

We show that the drift-diffusion mechanism in a normal-metal layer in combination with the resonance electron-magnon interactions at ferromagnet-normal interface of F-N-F heterostucture creates spatial instability modes and, out of these…

Adaptation and Self-Organizing Systems · Physics 2009-11-11 Pavel Levin

In computational neuroscience, it is common to use the simplifying assumption that diffusive currents are negligible compared to Ohmic currents. However, endured periods of intense neural signaling may cause local ion concentration changes…

Biological Physics · Physics 2017-02-08 Geir Halnes , Tuomo Mäki-Marttunen , Daniel Keller , Klas H. Pettersen , Gaute T. Einevoll

We present a novel methodology to enable control of a neuromorphic circuit in close analogy with the physiological neuromodulation of a single neuron. The methodology is general in that it only relies on a parallel interconnection of…

Neurons and Cognition · Quantitative Biology 2020-11-19 Luka Ribar , Rodolphe Sepulchre

The current - voltage dependence of the transverse tunneling current through the electron or hole traps in a DNA is investigated. The hopping of the charge between the sites of the trap and the charge-phonon coupling results in a staircase…

Mesoscale and Nanoscale Physics · Physics 2009-11-11 V. Apalkov , T. Chakraborty

Sensory arrays made of coupled excitable elements can improve both their input sensitivity and dynamic range due to collective non-linear wave properties. This mechanism is studied in a neural network of electrically coupled (e.g. via gap…

Disordered Systems and Neural Networks · Physics 2007-05-23 Mauro Copelli , Antonio C. Roque , Rodrigo F. Oliveira , Osame Kinouchi

The precise manipulation of transverse magnetic domain walls in finite/infinite nanowires with artificial defects under the influence of very short spin-polarized current pulses is investigated. We show that for a classical $3d$ ferromagnet…

Mesoscale and Nanoscale Physics · Physics 2018-01-09 A. Pivano , V. O. Dolocan

Direct observations of current-induced domain-wall propagation by spin-polarized scanning electron microscopy are reported. Current pulses move head-to-head as well as tail-to-tail walls in sub-micrometer Fe_{20}Ni_{80} wires in the…

Other Condensed Matter · Physics 2009-11-11 M. Klaui , P. -O. Jubert , R. Allenspach , A. Bischof , J. A. C. Bland , G. Faini , U. Rudiger , C. A. F. Vaz , L. Vila , C. Vouille

Stimulated by ongoing discussions about the relevance of mechanical motion in the propagation of nerve signals capillary waves of water-based electrolytes in elastic tubular systems are considered as an essential ingredient. Their…

Biological Physics · Physics 2019-09-27 Jörg P. Kotthaus

We report here new electrical laws, derived from nonlinear electro-diffusion theory, about the effect of the local geometrical structure, such as curvature, on the electrical properties of a cell. We adopt the Poisson-Nernst-Planck (PNP)…

Subcellular Processes · Quantitative Biology 2017-11-22 Jerome Cartailler , Zeev Schuss , David Holcman
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