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Computational methods are the most effective tools we have besides scientific experiments to explore the properties of complex biological systems. Progress is slowing because digital silicon computers have reached their limits in terms of…

Quantum Physics · Physics 2020-04-03 Viv Kendon

The transistor celebrated its 75${}^\text{th}$ birthday in 2022. The continued scaling of the transistor defined by Moore's Law continues, albeit at a slower pace. Meanwhile, computing demands and energy consumption required by modern…

Energy and power consumption are major limitations to continued scaling of computing systems. Inexactness, where the quality of the solution can be traded for energy savings, has been proposed as an approach to overcoming those limitations.…

Other Computer Science · Computer Science 2016-10-13 Sven Leyffer , Stefan M. Wild , Mike Fagan , Marc Snir , Krishna Palem , Kazutomo Yoshii , Hal Finkel

In this article we shall trace the historical development of tumour growth laws, which in a quantitative fashion describe the increase in tumour mass/volume over time. These models are usually formulated in terms of differential equations…

Tissues and Organs · Quantitative Biology 2013-02-11 P. Gerlee

Fluctuation theorems, which have been developed over the past 15 years, have resulted in fundamental breakthroughs in our understanding of how irreversibility emerges from reversible dynamics, and have provided new statistical mechanical…

Statistical Mechanics · Physics 2015-05-13 E. M. Sevick , R. Prabhakar , Stephen R. Williams , Debra J. Searles

The challenge of CPU evaluation lies in the fact that user-perceived performance metrics can only be measured on an independently running system consisting of the CPU and other indispensable components, and hence it is difficult to…

Performance · Computer Science 2025-07-16 Chenxi Wang , Lei Wang , Wanling Gao , Fanda Fan , Yuchen Su , Yutong Zhou , Yikang Yang , Jianfeng Zhan

Biological molecular machines are bifunctional enzymes that catalyze two processes: one donating free energy and the other accepting it. Recent studies show that most protein enzymes have rich stochastic dynamics of transitions between the…

Biological Physics · Physics 2023-02-02 Michal Kurzynski , Przemyslaw Chelminiak

For decades, Moore's Law has served as a steadfast pillar in computer architecture and system design, promoting a clear abstraction between hardware and software. This traditional Moore's computing paradigm has deepened the rift between the…

Hardware Architecture · Computer Science 2025-04-10 Amir Yazdanbakhsh

In the present paper, the models of structural analysis and evaluation of efficiency indicators (reliability, fault tolerance, viability, and flexibility) of a multi core processor with variable structure, equipped with multi functional…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-11-05 S. Tsiramua , H. Meladze , T. Davitashvili , J. M. Sanchez , F. Criado-Aldeanueva

In this paper the authors extend [1] and provide more details of how the brain may act like a quantum computer. In particular, positing the difference between voltages on two axons as the environment for ions undergoing spatial…

Neurons and Cognition · Quantitative Biology 2022-11-15 Aman Chawla , Salvatore Domenic Morgera

A new concept of the molecular structure optimization method based on quantum dynamics computations is presented. Nuclei are treated as quantum mechanical particles, as are electrons, and the many-body wave function of the system is…

While several paths have emerged in microelectronics and computing as follow-ons to Turing architectures, and have been implemented using essentially silicon circuits, very little beyond Moore research has considered: (1) first biological…

Emerging Technologies · Computer Science 2016-09-27 P. N. Borza , L-F Pau

In order to perceive that a physical system evolves in time, two requirements must be met: (a) it must be possible to define a "clock" and (b) it must be possible to make a copy of the state of the system, that can be reliably retrieved to…

Quantum Physics · Physics 2015-07-14 S. Nicolis

We present the evolution path of the first core in rotating molecular cloud core and the evolution during the second collapse phase using axisymmetric numerical calculations. The structure and evolution of the rotating first core is…

Astrophysics · Physics 2007-05-23 Kazuya Saigo , Kohji Tomisaka

Quantum fluctuations are fundamental in quantum technologies, affecting computing, sensing, cryptography, and thermodynamics. These include fluctuations in the variation of energy, charge, and other observables driven by interactions with…

Quantum Physics · Physics 2025-09-18 Thales Augusto Barbosa Pinto Silva , David Gelbwaser-Klimovsky

We investigate the mutation-selection dynamics for an evolutionary computation model based on Turing Machines that we introduced in a previous article. The use of Turing Machines allows for very simple mechanisms of code growth and code…

Populations and Evolution · Quantitative Biology 2015-03-17 Fabio Musso , Giovanni Feverati

We introduce and experimentally validate a new macro-level model of the CPU temperature/power relationship within nanometer-scale application processors or system-on-chips. By adopting a holistic view, this model is able to take into…

Hardware Architecture · Computer Science 2014-04-15 Karel De Vogeleer , Gerard Memmi , Pierre Jouvelot , Fabien Coelho

Invention of Transistors in 1948 started a new era in technology, called Solid State Electronics. Since then, sustaining development and advancement in electronics and fabrication techniques has caused the devices to shrink in size and…

Hardware Architecture · Computer Science 2010-11-16 Md. Tanvir Al Amin

In a previous paper we introduced a new method for simulating collisional gravitational $N$-body systems with linear time scaling on $N$, based on the Multi-Particle Collision (MPC) approach. This allows us to simulate globular clusters…

Astrophysics of Galaxies · Physics 2022-03-04 Pierfrancesco Di Cintio , Mario Pasquato , Alicia Simon-Petit , Suk-Jin Yoon

For a number of starless cores, self-absorbed molecular line and column density observations have implied the presence of large-amplitude oscillations. We examine the consequences of these oscillations on the evolution of the cores and the…

Solar and Stellar Astrophysics · Physics 2015-05-19 Avery E. Broderick , Eric Keto