Related papers: Multi-part balanced incomplete-block designs
We prove three theorems giving extremal bounds on the incidence structures determined by subsets of the points and blocks of a balanced incomplete block design (BIBD). These results generalize and strengthen known bounds on the number of…
Making technology design inclusive requires facing multiple challenges in different dimensions: the populations we work with, who we are, what interaction possibilities we consider, and what context we examine. We reflect on these…
Recent advances in high-throughput genomic technologies coupled with exponential increases in computer processing and memory have allowed us to interrogate the complex aberrant molecular underpinnings of human disease from a genome-wide…
Machine learning-based multi-label medical text classifications can be used to enhance the understanding of the human body and aid the need for patient care. We present a broad study on clinical natural language processing techniques to…
Despite all the advances achieved in the field of tumor-biology research, in most cases conventional therapies including chemotherapy are still the leading choices. The main disadvantage of these treatments, in addition to the low…
The assessment of imaging biomarkers is critical for advancing precision medicine and improving disease characterization. Despite the availability of methods to derive disease heterogeneity metrics in imaging studies, a robust framework for…
Personalizing drug prescriptions in cancer care based on genomic information requires associating genomic markers with treatment effects. This is an unsolved challenge requiring genomic patient data in yet unavailable volumes as well as…
Recent advancements in model checking have demonstrated significant potential across diverse applications, particularly in signal and image analysis. Medical imaging stands out as a critical domain where model checking can be effectively…
Recently, a construction of group divisible designs (GDDs) derived from the decoding of quadratic residue (QR) codes was given. In this paper, we extend the idea to obtain a new family of GDDs, which is also involved with a well-known…
We provide a method to construct $t$-designs from weighing matrices and association schemes. One instance of our method can produce a $3$-design from any (symmetric or skew-symmetric) conference matrix, thereby providing a partial answer to…
This manuscript introduces an \proglang{R} package called \pkg{trialr} that implements a collection of clinical trial methods in \proglang{Stan} and \proglang{R}. In this article, we explore three methods in detail. The first is the…
This paper proposes a general framework for probabilistic certification of cancer therapies. The certification is defined in terms of two key issues which are the tumor contraction and the lower admissible bound on the circulating…
Certain cancer types, notably pancreatic cancer, are difficult to detect at an early stage, motivating robust biomarker-based screening. Liquid biopsies enable non-invasive monitoring of circulating biomarkers, but typical machine learning…
This paper studies circular designs for interference models, where a treatment assigned to a plot also affects its neighboring plots within a block. For the purpose of estimating total effects, the circular neighbor balanced design was…
Numerous publications have now addressed the principles of designing, analyzing, and reporting the results of, stepped-wedge cluster randomized trials. In contrast, there is little research available pertaining to the design and analysis of…
Polymeric micelles are used in a variety of applications, with the micelle's shape often playing an important role. Consequently, a scheme to design micelles of arbitrary shape is desirable. In this paper, we consider micelles formed from a…
One of the challenges in Synthetic Biology is to design circuits with increasing levels of complexity. While circuits in Biology are complex and subject to natural tradeoffs, most synthetic circuits are simple in terms of the number of…
We improve the existing results of optimal partial profile paired choice designs and provide new designs for situations where the choice set sizes are greater than two. The optimal designs are obtained under the main effects models and the…
We identify three properties of the standard oncology phase I trial design or 3 + 3 design. We show that the standard design implicitly uses isotonic regression to estimate a maximum tolerated dose. We next illustrate the relationship…
A central goal in designing clinical trials is to find the test that maximizes power (or equivalently minimizes required sample size) for finding a false null hypothesis subject to the constraint of type I error. When there is more than one…