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Change-point models are frequently considered when modeling phenomena where a regime shift occurs at an unknown time. In ageing research, these models are commonly adopted to estimate of the onset of cognitive decline. Yet commonly used…
Glaucoma is a chronic eye disease that leads to irreversible vision loss. Most of the existing automatic screening methods firstly segment the main structure, and subsequently calculate the clinical measurement for detection and screening…
Glaucoma is a chronic visual disease that may cause permanent irreversible blindness. Measurement of the cup-to-disc ratio (CDR) plays a pivotal role in the detection of glaucoma in its early stage, preventing visual disparities. Therefore,…
This paper introduces the modeling of circular data with excess zeros under a longitudinal framework, where the response is a circular variable and the covariates can be both linear and circular in nature. In the literature, various…
Glaucoma is a leading cause of irreversible vision impairment globally and cases are continuously rising worldwide. Early detection is crucial, allowing timely intervention which can prevent further visual field loss. To detect glaucoma,…
$\bf{Purpose}$: To describe the 3D structural changes in both connective and neural tissues of the optic nerve head (ONH) that occur concurrently at different stages of glaucoma using traditional and AI-driven approaches. $\bf{Methods}$: We…
Retinopathy represents a group of retinal diseases that, if not treated timely, can cause severe visual impairments or even blindness. Many researchers have developed autonomous systems to recognize retinopathy via fundus and optical…
Myopia in human and animals is caused by the axial elongation of the eye and is closely linked to the thinning of the sclera which supports the eye tissue. This thinning has been correlated with the overproduction of matrix…
Differences in image quality, lighting conditions, and patient demographics pose challenges to automated glaucoma detection from color fundus photography. Brighteye, a method based on Vision Transformer, is proposed for glaucoma detection…
The diagnosis of glaucoma plays a critical role in the management and treatment of this vision-threatening disease. Glaucoma is a group of eye diseases that cause blindness by damaging the optic nerve at the back of the eye. Often called…
Glaucoma is a common eye disease that leads to irreversible blindness unless timely detected. Hence, glaucoma detection at an early stage is of utmost importance for a better treatment plan and ultimately saving the vision. The recent…
Glaucoma is the second leading cause of blindness all over the world, with approximately 60 million cases reported worldwide in 2010. If undiagnosed in time, glaucoma causes irreversible damage to the optic nerve leading to blindness. The…
Glaucoma is a major cause of irreversible blindness, with significant diagnostic subjectivity. This inherent uncertainty, combined with the overconfidence of models optimized solely for accuracy can lead to fatal issues such as…
We expand Mendelian Randomization (MR) methodology to deal with randomly missing data on either the exposure or the outcome variable, and furthermore with data from nonindependent individuals (eg components of a family). Our method rests on…
Glaucoma is a leading cause of irreversible blindness worldwide, emphasizing the critical need for early detection and intervention. In this paper, we present DeepEyeNet, a novel and comprehensive framework for automated glaucoma detection…
Understanding of the pathophysiology of obstructive lung disease (OLD) is limited by available methods to examine the relationship between multi-omic molecular phenomena and clinical outcomes. Integrative factorization methods for…
Parkinson's disease (PD) belongs to the class of neurodegenerative disorders that affect the central nervous system. It is usually defined as the gradual loss of dopaminergic neurons in the substantia nigra pars compacta, which causes both…
Dynamic prediction of causal effects under different treatment regimes conditional on an individual's characteristics and longitudinal history is an essential problem in precision medicine. This is challenging in practice because outcomes…
Glaucoma is a severe blinding disease, for which automatic detection methods are urgently needed to alleviate the scarcity of ophthalmologists. Many works have proposed to employ deep learning methods that involve the segmentation of optic…
Multiple Sclerosis (MS) is a chronic and potentially highly disabling disease that can cause permanent damage and deterioration of the central nervous system. In Europe it is the leading cause of non-traumatic disabilities in young adults,…